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Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer
Milk is an important commodity in Kenya; the country has the largest dairy herd and highest per capita milk consumption in East Africa. As such, hazards in milk are of concern. Aflatoxin M(1) (AFM(1)) is a toxic metabolite of aflatoxin B(1) (AFB(1)) excreted in milk by lactating animals after ingest...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722829/ https://www.ncbi.nlm.nih.gov/pubmed/31405092 http://dx.doi.org/10.3390/toxins11080469 |
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author | Sirma, Anima J. Makita, Kohei Grace Randolph, Delia Senerwa, Daniel Lindahl, Johanna F. |
author_facet | Sirma, Anima J. Makita, Kohei Grace Randolph, Delia Senerwa, Daniel Lindahl, Johanna F. |
author_sort | Sirma, Anima J. |
collection | PubMed |
description | Milk is an important commodity in Kenya; the country has the largest dairy herd and highest per capita milk consumption in East Africa. As such, hazards in milk are of concern. Aflatoxin M(1) (AFM(1)) is a toxic metabolite of aflatoxin B(1) (AFB(1)) excreted in milk by lactating animals after ingesting AFB(1)-contaminated feeds. This metabolite is injurious to human health, but there is little information on the risk to human health posed by AFM(1) in milk in rural Kenya. To fill this gap, a quantitative risk assessment (QRA) applying probabilistic statistical tools to quantify risks was conducted. This assessed the risk of liver cancer posed by AFM(1) in milk, assuming 10-fold lower carcinogenicity than AFB(1). Data from four agro–ecological zones in Kenya (semi-arid, temperate, sub-humid and humid) were used. We estimated that people were exposed to between 0.3 and 1 ng AFM(1) per kg body weight per day through the consumption of milk. The annual incidence rates of cancer attributed to the consumption of AFM(1) in milk were 3.5 × 10(−3) (95% CI: 3 × 10(−3)–3.9 × 10(−3)), 2.9 × 10(−3) (95% CI: 2.5 × 10(−3)–3.3 × 10(−3)), 1.4 × 10(−3) (95% CI: 1.2 × 10(−3)–1.5 × 10(−3)) and 2.7 × 10(−3) (95% CI: 2.3 × 10(−3)–3 × 10(−3)) cancers per 100,000 in adult females, adult males, children 6–18 years old, and in children less than five years old, respectively. Our results show that aflatoxin exposure from milk contributes relatively little to the incidence of liver cancer. Nonetheless, risk managers should take action based on cumulative exposure from all sources of aflatoxins. |
format | Online Article Text |
id | pubmed-6722829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67228292019-09-10 Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer Sirma, Anima J. Makita, Kohei Grace Randolph, Delia Senerwa, Daniel Lindahl, Johanna F. Toxins (Basel) Article Milk is an important commodity in Kenya; the country has the largest dairy herd and highest per capita milk consumption in East Africa. As such, hazards in milk are of concern. Aflatoxin M(1) (AFM(1)) is a toxic metabolite of aflatoxin B(1) (AFB(1)) excreted in milk by lactating animals after ingesting AFB(1)-contaminated feeds. This metabolite is injurious to human health, but there is little information on the risk to human health posed by AFM(1) in milk in rural Kenya. To fill this gap, a quantitative risk assessment (QRA) applying probabilistic statistical tools to quantify risks was conducted. This assessed the risk of liver cancer posed by AFM(1) in milk, assuming 10-fold lower carcinogenicity than AFB(1). Data from four agro–ecological zones in Kenya (semi-arid, temperate, sub-humid and humid) were used. We estimated that people were exposed to between 0.3 and 1 ng AFM(1) per kg body weight per day through the consumption of milk. The annual incidence rates of cancer attributed to the consumption of AFM(1) in milk were 3.5 × 10(−3) (95% CI: 3 × 10(−3)–3.9 × 10(−3)), 2.9 × 10(−3) (95% CI: 2.5 × 10(−3)–3.3 × 10(−3)), 1.4 × 10(−3) (95% CI: 1.2 × 10(−3)–1.5 × 10(−3)) and 2.7 × 10(−3) (95% CI: 2.3 × 10(−3)–3 × 10(−3)) cancers per 100,000 in adult females, adult males, children 6–18 years old, and in children less than five years old, respectively. Our results show that aflatoxin exposure from milk contributes relatively little to the incidence of liver cancer. Nonetheless, risk managers should take action based on cumulative exposure from all sources of aflatoxins. MDPI 2019-08-10 /pmc/articles/PMC6722829/ /pubmed/31405092 http://dx.doi.org/10.3390/toxins11080469 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sirma, Anima J. Makita, Kohei Grace Randolph, Delia Senerwa, Daniel Lindahl, Johanna F. Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer |
title | Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer |
title_full | Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer |
title_fullStr | Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer |
title_full_unstemmed | Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer |
title_short | Aflatoxin Exposure from Milk in Rural Kenya and the Contribution to the Risk of Liver Cancer |
title_sort | aflatoxin exposure from milk in rural kenya and the contribution to the risk of liver cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722829/ https://www.ncbi.nlm.nih.gov/pubmed/31405092 http://dx.doi.org/10.3390/toxins11080469 |
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