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The Baseline Nutritional Status Predicts Long-Term Mortality in Patients Undergoing Endovascular Therapy
Introduction: Peripheral artery disease (PAD) occurs at an advanced stage of atherosclerosis and its comorbidities are associated with poor prognoses. Malnutrition is related to the severity of atherosclerosis in patients with cardiovascular disease and it predicts mortality. The Controlling Nutriti...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722841/ https://www.ncbi.nlm.nih.gov/pubmed/31362417 http://dx.doi.org/10.3390/nu11081745 |
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author | Mizobuchi, Keiko Jujo, Kentaro Minami, Yuichiro Ishida, Issei Nakao, Masashi Hagiwara, Nobuhisa |
author_facet | Mizobuchi, Keiko Jujo, Kentaro Minami, Yuichiro Ishida, Issei Nakao, Masashi Hagiwara, Nobuhisa |
author_sort | Mizobuchi, Keiko |
collection | PubMed |
description | Introduction: Peripheral artery disease (PAD) occurs at an advanced stage of atherosclerosis and its comorbidities are associated with poor prognoses. Malnutrition is related to the severity of atherosclerosis in patients with cardiovascular disease and it predicts mortality. The Controlling Nutritional Status (CONUT) score is calculated from serum albumin concentration, peripheral lymphocyte count and total cholesterol concentration, and it robustly represents the nutritional status of hospitalized patients. This study aimed to determine the prognostic value of the CONUT score in patients with peripheral artery disease (PAD) who were undergoing endovascular therapy (EVT). METHODS and RESULTS: This study included 628 PAD patients who underwent EVT between 2013 and 2017 and were assigned to low (CONUT score 0: n = 81), mild (CONUT score 1–2: n = 250), moderate (CONUT score 3–4: n = 169), and high (CONUT score ≥ 5: n = 128) risk groups. The study’s primary endpoint was any death. Patients in the groups with higher CONUT scores were more likely to have chronic kidney disease (p < 0.001), impaired left ventricular ejection fractions (p < 0.001), and critical limb ischemia (p < 0.001) on admission. During follow-up, 95 patients (15%) died. Kaplan–Meier analyses revealed that the patients with higher CONUT scores had lower survival rates (p < 0.001; log-rank trend test). Multivariate Cox regression analyses showed that following adjustments for the confounding factors, a higher CONUT score was significantly associated with any death (hazard ratio, 1.15; 95% confidence interval, 1.03–1.30). CONCLUSION: The simple index CONUT score at the time of EVT may predict long-term mortality in PAD patients. |
format | Online Article Text |
id | pubmed-6722841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67228412019-09-10 The Baseline Nutritional Status Predicts Long-Term Mortality in Patients Undergoing Endovascular Therapy Mizobuchi, Keiko Jujo, Kentaro Minami, Yuichiro Ishida, Issei Nakao, Masashi Hagiwara, Nobuhisa Nutrients Article Introduction: Peripheral artery disease (PAD) occurs at an advanced stage of atherosclerosis and its comorbidities are associated with poor prognoses. Malnutrition is related to the severity of atherosclerosis in patients with cardiovascular disease and it predicts mortality. The Controlling Nutritional Status (CONUT) score is calculated from serum albumin concentration, peripheral lymphocyte count and total cholesterol concentration, and it robustly represents the nutritional status of hospitalized patients. This study aimed to determine the prognostic value of the CONUT score in patients with peripheral artery disease (PAD) who were undergoing endovascular therapy (EVT). METHODS and RESULTS: This study included 628 PAD patients who underwent EVT between 2013 and 2017 and were assigned to low (CONUT score 0: n = 81), mild (CONUT score 1–2: n = 250), moderate (CONUT score 3–4: n = 169), and high (CONUT score ≥ 5: n = 128) risk groups. The study’s primary endpoint was any death. Patients in the groups with higher CONUT scores were more likely to have chronic kidney disease (p < 0.001), impaired left ventricular ejection fractions (p < 0.001), and critical limb ischemia (p < 0.001) on admission. During follow-up, 95 patients (15%) died. Kaplan–Meier analyses revealed that the patients with higher CONUT scores had lower survival rates (p < 0.001; log-rank trend test). Multivariate Cox regression analyses showed that following adjustments for the confounding factors, a higher CONUT score was significantly associated with any death (hazard ratio, 1.15; 95% confidence interval, 1.03–1.30). CONCLUSION: The simple index CONUT score at the time of EVT may predict long-term mortality in PAD patients. MDPI 2019-07-29 /pmc/articles/PMC6722841/ /pubmed/31362417 http://dx.doi.org/10.3390/nu11081745 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mizobuchi, Keiko Jujo, Kentaro Minami, Yuichiro Ishida, Issei Nakao, Masashi Hagiwara, Nobuhisa The Baseline Nutritional Status Predicts Long-Term Mortality in Patients Undergoing Endovascular Therapy |
title | The Baseline Nutritional Status Predicts Long-Term Mortality in Patients Undergoing Endovascular Therapy |
title_full | The Baseline Nutritional Status Predicts Long-Term Mortality in Patients Undergoing Endovascular Therapy |
title_fullStr | The Baseline Nutritional Status Predicts Long-Term Mortality in Patients Undergoing Endovascular Therapy |
title_full_unstemmed | The Baseline Nutritional Status Predicts Long-Term Mortality in Patients Undergoing Endovascular Therapy |
title_short | The Baseline Nutritional Status Predicts Long-Term Mortality in Patients Undergoing Endovascular Therapy |
title_sort | baseline nutritional status predicts long-term mortality in patients undergoing endovascular therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722841/ https://www.ncbi.nlm.nih.gov/pubmed/31362417 http://dx.doi.org/10.3390/nu11081745 |
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