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GCKR rs780094 Polymorphism as A Genetic Variant Involved in Physical Exercise

Exercise performance is influenced by genetics. However, there is a lack of knowledge about the role played by genetic variability in the frequency of physical exercise practice. The objective was to identify genetic variants that modulate the commitment of people to perform physical exercise and to...

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Autores principales: Espinosa-Salinas, Isabel, de la Iglesia, Rocio, Colmenarejo, Gonzalo, Molina, Susana, Reglero, Guillermo, Martinez, J. Alfredo, Loria-Kohen, Viviana, Ramirez de Molina, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722860/
https://www.ncbi.nlm.nih.gov/pubmed/31357711
http://dx.doi.org/10.3390/genes10080570
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author Espinosa-Salinas, Isabel
de la Iglesia, Rocio
Colmenarejo, Gonzalo
Molina, Susana
Reglero, Guillermo
Martinez, J. Alfredo
Loria-Kohen, Viviana
Ramirez de Molina, Ana
author_facet Espinosa-Salinas, Isabel
de la Iglesia, Rocio
Colmenarejo, Gonzalo
Molina, Susana
Reglero, Guillermo
Martinez, J. Alfredo
Loria-Kohen, Viviana
Ramirez de Molina, Ana
author_sort Espinosa-Salinas, Isabel
collection PubMed
description Exercise performance is influenced by genetics. However, there is a lack of knowledge about the role played by genetic variability in the frequency of physical exercise practice. The objective was to identify genetic variants that modulate the commitment of people to perform physical exercise and to detect those subjects with a lower frequency practice. A total of 451 subjects were genotyped for 64 genetic variants related to inflammation, circadian rhythms, vascular function as well as energy, lipid and carbohydrate metabolism. Physical exercise frequency question and a Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ) were used to qualitatively and quantitatively measure the average amount of physical exercise. Dietary intake and energy expenditure due to physical activity were also studied. Differences between genotypes were analyzed using linear and logistic models adjusted for Bonferroni. A significant association between GCKR rs780094 and the times the individuals performed physical exercise was observed (p = 0.004). The carriers of the minor allele showed a greater frequency of physical exercise in comparison to the major homozygous genotype carriers (OR: 1.86, 95% CI: 1.36–2.56). The analysis of the GCKR rs780094 variant suggests a possible association with the subjects that present lower frequency of physical exercise. Nevertheless, future studies are needed to confirm these findings.
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spelling pubmed-67228602019-09-10 GCKR rs780094 Polymorphism as A Genetic Variant Involved in Physical Exercise Espinosa-Salinas, Isabel de la Iglesia, Rocio Colmenarejo, Gonzalo Molina, Susana Reglero, Guillermo Martinez, J. Alfredo Loria-Kohen, Viviana Ramirez de Molina, Ana Genes (Basel) Article Exercise performance is influenced by genetics. However, there is a lack of knowledge about the role played by genetic variability in the frequency of physical exercise practice. The objective was to identify genetic variants that modulate the commitment of people to perform physical exercise and to detect those subjects with a lower frequency practice. A total of 451 subjects were genotyped for 64 genetic variants related to inflammation, circadian rhythms, vascular function as well as energy, lipid and carbohydrate metabolism. Physical exercise frequency question and a Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ) were used to qualitatively and quantitatively measure the average amount of physical exercise. Dietary intake and energy expenditure due to physical activity were also studied. Differences between genotypes were analyzed using linear and logistic models adjusted for Bonferroni. A significant association between GCKR rs780094 and the times the individuals performed physical exercise was observed (p = 0.004). The carriers of the minor allele showed a greater frequency of physical exercise in comparison to the major homozygous genotype carriers (OR: 1.86, 95% CI: 1.36–2.56). The analysis of the GCKR rs780094 variant suggests a possible association with the subjects that present lower frequency of physical exercise. Nevertheless, future studies are needed to confirm these findings. MDPI 2019-07-28 /pmc/articles/PMC6722860/ /pubmed/31357711 http://dx.doi.org/10.3390/genes10080570 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Espinosa-Salinas, Isabel
de la Iglesia, Rocio
Colmenarejo, Gonzalo
Molina, Susana
Reglero, Guillermo
Martinez, J. Alfredo
Loria-Kohen, Viviana
Ramirez de Molina, Ana
GCKR rs780094 Polymorphism as A Genetic Variant Involved in Physical Exercise
title GCKR rs780094 Polymorphism as A Genetic Variant Involved in Physical Exercise
title_full GCKR rs780094 Polymorphism as A Genetic Variant Involved in Physical Exercise
title_fullStr GCKR rs780094 Polymorphism as A Genetic Variant Involved in Physical Exercise
title_full_unstemmed GCKR rs780094 Polymorphism as A Genetic Variant Involved in Physical Exercise
title_short GCKR rs780094 Polymorphism as A Genetic Variant Involved in Physical Exercise
title_sort gckr rs780094 polymorphism as a genetic variant involved in physical exercise
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722860/
https://www.ncbi.nlm.nih.gov/pubmed/31357711
http://dx.doi.org/10.3390/genes10080570
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