Cargando…

Accurate Classification of Non-small Cell Lung Cancer (NSCLC) Pathology and Mapping of EGFR Mutation Spatial Distribution by Ambient Mass Spectrometry Imaging

Objectives: Tumor pathology examination especially epidermal growth factor receptor (EGFR) mutations molecular testing has been integral part of lung cancer clinical practices. However, the EGFR mutations spatial distribution characteristics remains poorly investigated, which is critical to tumor he...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Min, He, Jiuming, Li, Tiegang, Hu, Haixu, Li, Xiaofei, Xing, Hao, Wang, Jun, Yang, Fan, Ma, Qunfeng, Liu, Bing, Tang, Chuanhao, Abliz, Zeper, Liu, Xiaoqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722907/ https://www.ncbi.nlm.nih.gov/pubmed/31555581 http://dx.doi.org/10.3389/fonc.2019.00804

Ejemplares similares

A Sensitive and Wide Coverage Ambient Mass Spectrometry Imaging Method for Functional Metabolites Based Molecular Histology
por: He, Jiuming, et al.
Publicado: (2018)

Identification of Diagnostic Metabolic Signatures in Thyroid Tumors Using Mass Spectrometry Imaging
por: Mao, Xinxin, et al.
Publicado: (2023)

In situ biomarker discovery and label-free molecular histopathological diagnosis of lung cancer by ambient mass spectrometry imaging
por: Li, Tiegang, et al.
Publicado: (2015)

Application of imaging mass spectrometry for the molecular diagnosis of human breast tumors
por: Mao, Xinxin, et al.
Publicado: (2016)

Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids
por: Li, Limei, et al.
Publicado: (2023)

Molecular Pathological Diagnosis of Thyroid Tumors Using Spatially Resolved Metabolomics
por: Huang, Luojiao, et al.
Publicado: (2022)

Evaluation of the tumor-targeting efficiency and intratumor heterogeneity of anticancer drugs using quantitative mass spectrometry imaging
por: Zhang, Jin, et al.
Publicado: (2020)

A targeted neurotransmitter quantification and nontargeted metabolic profiling method for pharmacometabolomics analysis of olanzapine by using UPLC-HRMS
por: Liu, Dan, et al.
Publicado: (2020)

Spatially resolved metabolomics to discover tumor-associated metabolic alterations
por: Sun, Chenglong, et al.
Publicado: (2019)

Ratiometric Mass Spectrometry Imaging for Stain-Free Delineation of Ischemic Tissue and Spatial Profiling of Ischemia-Related Molecular Signatures
por: Wang, Zixuan, et al.
Publicado: (2021)

A temporo-spatial pharmacometabolomics method to characterize pharmacokinetics and pharmacodynamics in the brain microregions by using ambient mass spectrometry imaging
por: Liu, Dan, et al.
Publicado: (2022)

Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging
por: Wang, Zhonghua, et al.
Publicado: (2021)

Rapid and sensitive liquid chromatography–tandem mass spectrometric method for the quantitative determination of potentially harmful substance 5,5′-oxydimethylenebis (2-furfural) in traditional Chinese medicine injections
por: Zang, Qingce, et al.
Publicado: (2018)

In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging
por: Wang, Zhonghua, et al.
Publicado: (2020)

Global metabolomics reveals potential urinary biomarkers of esophageal squamous cell carcinoma for diagnosis and staging
por: Xu, Jing, et al.
Publicado: (2016)

Spatiotemporally resolved metabolomics and isotope tracing reveal CNS drug targets
por: Jin, Bo, et al.
Publicado: (2023)

Comparison of Local Metabolic Changes in Diabetic Rodent Kidneys Using Mass Spectrometry Imaging
por: Zhang, Xin, et al.
Publicado: (2023)

Rewiring of purine metabolism in response to acidosis stress in glioma stem cells
por: Xu, Xiaoyu, et al.
Publicado: (2021)

Mass spectrometry-based serum peptidome profiling accurately and reliably predicts outcomes of pemetrexed plus platinum chemotherapy in patients with advanced lung adenocarcinoma
por: Wang, Lin, et al.
Publicado: (2017)

Structure-based classification predicts drug response in EGFR-mutant NSCLC
por: Robichaux, Jacqulyne P., et al.
Publicado: (2021)

Combination of EGFR-TKIs with chemotherapy versus chemotherapy or EGFR-TKIs alone in advanced NSCLC patients with EGFR mutation
por: Wen, Miaomiao, et al.
Publicado: (2018)

Discovery of a novel EGFR ligand DPBA that degrades EGFR and suppresses EGFR-positive NSCLC growth
por: Yao, Nan, et al.
Publicado: (2020)

Efficacy of dacomitinib in patients with EGFR‐mutated NSCLC and brain metastases
por: Zhang, Jinyao, et al.
Publicado: (2021)

Unexpected responses to EGFR inhibition in NSCLC
por: Stella, Giulia M., et al.
Publicado: (2015)

Silibinin Inhibits NSCLC Metastasis by Targeting the EGFR/LOX Pathway
por: Hou, Xiaoying, et al.
Publicado: (2018)

PET/CT Based EGFR Mutation Status Classification of NSCLC Using Deep Learning Features and Radiomics Features
por: Huang, Weicheng, et al.
Publicado: (2022)

The Impact of Histological Annotations for Accurate Tissue Classification Using Mass Spectrometry Imaging
por: Gonçalves, Juliana Pereira Lopes, et al.
Publicado: (2021)

FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth
por: Niu, Mengmeng, et al.
Publicado: (2021)

Estimation of cell-free circulating EGFR mutation concentration predicts outcomes in NSCLC patients treated with EGFR-TKIs
por: Zhu, Yan-juan, et al.
Publicado: (2017)

ERβ localization influenced outcomes of EGFR-TKI treatment in NSCLC patients with EGFR mutations
por: Wang, Zhijie, et al.
Publicado: (2015)

Prognostic value of plasma EGFR ctDNA in NSCLC patients treated with EGFR-TKIs
por: Zhang, Chengjuan, et al.
Publicado: (2017)

Research Progress in Immunotherapy of NSCLC With EGFR-Sensitive Mutations
por: Yang, Yudie, et al.
Publicado: (2022)

Continuous Vaginal Bleeding Induced By EGFR-TKI in Premenopausal Female Patients With EGFR Mutant NSCLC
por: Yu, Min, et al.
Publicado: (2022)

Sulforaphane attenuates EGFR signaling in NSCLC cells
por: Chen, Chi-Yuan, et al.
Publicado: (2015)

EGFR-Targeted Therapeutics: Focus on SCCHN and NSCLC
por: Sattler, Martin, et al.
Publicado: (2008)

Immunotherapy strategies for EGFR-mutated advanced NSCLC after EGFR tyrosine-kinase inhibitors failure
por: Li, Xingyuan, et al.
Publicado: (2023)

Spatial Distribution Analysis of Novel Texture Feature Descriptors for Accurate Breast Density Classification
por: Li, Haipeng, et al.
Publicado: (2022)

Accurate de novo peptide sequencing using fully convolutional neural networks
por: Liu, Kaiyuan, et al.
Publicado: (2023)

The efficacy of adding hyperthermia to the treatment of advanced NSCLC patients based on the states of EGFR
por: Zhou, Yanhua, et al.
Publicado: (2022)

Microwave ablation combined with EGFR-TKIs versus only EGFR-TKIs in advanced NSCLC patients with EGFR-sensitive mutations
por: Wei, Zhigang, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_fp7hg8v10bs1lqsj7k4cpkc9co