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Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods
The aims of this study were to investigate how the release of tadalafil is influenced by two grades of polyvinylpyrrolidone (Kollidon(®) 12 PF and Kollidon(®) VA 64) and various methods of preparing solid dispersions (solvent evaporation, spray drying and hot-melt extrusion). Tadalafil is poorly wat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722951/ https://www.ncbi.nlm.nih.gov/pubmed/31382377 http://dx.doi.org/10.3390/pharmaceutics11080383 |
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author | Školáková, Tereza Slámová, Michaela Školáková, Andrea Kadeřábková, Alena Patera, Jan Zámostný, Petr |
author_facet | Školáková, Tereza Slámová, Michaela Školáková, Andrea Kadeřábková, Alena Patera, Jan Zámostný, Petr |
author_sort | Školáková, Tereza |
collection | PubMed |
description | The aims of this study were to investigate how the release of tadalafil is influenced by two grades of polyvinylpyrrolidone (Kollidon(®) 12 PF and Kollidon(®) VA 64) and various methods of preparing solid dispersions (solvent evaporation, spray drying and hot-melt extrusion). Tadalafil is poorly water-soluble and its high melting point makes it very sensitive to the solid dispersion preparation method. Therefore, the objectives were to make a comparative evaluation among different solid dispersions and to assess the effect of the physicochemical nature of solid dispersions on the drug release profile with respect to the erosion-diffusion mechanism. The solid dispersions were evaluated for dissolution profiles, XRD, SEM, FT-IR, DSC, and solubility or stability studies. It was found that tadalafil release was influenced by polymer molecular weight. Therefore, solid dispersions containing Kollidon(®) 12 PF showed a faster dissolution rate compared to Kollidon(®) VA 64. Tadalafil was released from solid dispersions containing Kollidon(®) 12 PF because of the combination of erosion and diffusion mechanisms. The diffusion mechanisms were predominant in the initial phase of the experiment and the slow erosion was dissolution-controlling at the second stage of the dissolution. On the contrary, the tadalafil release rate from solid dispersions containing Kollidon(®) VA 64 was controlled solely by the erosion mechanism. |
format | Online Article Text |
id | pubmed-6722951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67229512019-09-10 Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods Školáková, Tereza Slámová, Michaela Školáková, Andrea Kadeřábková, Alena Patera, Jan Zámostný, Petr Pharmaceutics Article The aims of this study were to investigate how the release of tadalafil is influenced by two grades of polyvinylpyrrolidone (Kollidon(®) 12 PF and Kollidon(®) VA 64) and various methods of preparing solid dispersions (solvent evaporation, spray drying and hot-melt extrusion). Tadalafil is poorly water-soluble and its high melting point makes it very sensitive to the solid dispersion preparation method. Therefore, the objectives were to make a comparative evaluation among different solid dispersions and to assess the effect of the physicochemical nature of solid dispersions on the drug release profile with respect to the erosion-diffusion mechanism. The solid dispersions were evaluated for dissolution profiles, XRD, SEM, FT-IR, DSC, and solubility or stability studies. It was found that tadalafil release was influenced by polymer molecular weight. Therefore, solid dispersions containing Kollidon(®) 12 PF showed a faster dissolution rate compared to Kollidon(®) VA 64. Tadalafil was released from solid dispersions containing Kollidon(®) 12 PF because of the combination of erosion and diffusion mechanisms. The diffusion mechanisms were predominant in the initial phase of the experiment and the slow erosion was dissolution-controlling at the second stage of the dissolution. On the contrary, the tadalafil release rate from solid dispersions containing Kollidon(®) VA 64 was controlled solely by the erosion mechanism. MDPI 2019-08-02 /pmc/articles/PMC6722951/ /pubmed/31382377 http://dx.doi.org/10.3390/pharmaceutics11080383 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Školáková, Tereza Slámová, Michaela Školáková, Andrea Kadeřábková, Alena Patera, Jan Zámostný, Petr Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods |
title | Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods |
title_full | Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods |
title_fullStr | Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods |
title_full_unstemmed | Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods |
title_short | Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods |
title_sort | investigation of dissolution mechanism and release kinetics of poorly water-soluble tadalafil from amorphous solid dispersions prepared by various methods |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722951/ https://www.ncbi.nlm.nih.gov/pubmed/31382377 http://dx.doi.org/10.3390/pharmaceutics11080383 |
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