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Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods

The aims of this study were to investigate how the release of tadalafil is influenced by two grades of polyvinylpyrrolidone (Kollidon(®) 12 PF and Kollidon(®) VA 64) and various methods of preparing solid dispersions (solvent evaporation, spray drying and hot-melt extrusion). Tadalafil is poorly wat...

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Detalles Bibliográficos
Autores principales:	Školáková, Tereza, Slámová, Michaela, Školáková, Andrea, Kadeřábková, Alena, Patera, Jan, Zámostný, Petr
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722951/ https://www.ncbi.nlm.nih.gov/pubmed/31382377 http://dx.doi.org/10.3390/pharmaceutics11080383

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