Cargando…
Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System
Vitamin A is a fundamental micronutrient that regulates various cellular patterns. Vitamin A deficiency (VAT) is a worldwide problem and the primary cause of nocturnal blindness especially in low income countries. Cystic fibrosis (CF) is a known risk factor of VAD because of liposoluble vitamin mala...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723039/ https://www.ncbi.nlm.nih.gov/pubmed/31412557 http://dx.doi.org/10.3390/nu11081876 |
_version_ | 1783448675555475456 |
---|---|
author | Norsa, Lorenzo Zazzeron, Laura Cuomo, Marialaura Claut, Laura Bulfamante, Anna Marta Clotilde Biffi, Arianna Colombo, Carla |
author_facet | Norsa, Lorenzo Zazzeron, Laura Cuomo, Marialaura Claut, Laura Bulfamante, Anna Marta Clotilde Biffi, Arianna Colombo, Carla |
author_sort | Norsa, Lorenzo |
collection | PubMed |
description | Vitamin A is a fundamental micronutrient that regulates various cellular patterns. Vitamin A deficiency (VAT) is a worldwide problem and the primary cause of nocturnal blindness especially in low income countries. Cystic fibrosis (CF) is a known risk factor of VAD because of liposoluble vitamin malabsorption due to pancreatic insufficiency. We describe a case of a 9-year-old girl who experienced recurrent episodes of nocturnal blindness due to profound VAD. This little girl is paradigmatic for the explanation of the key role of the gut–liver axis in vitamin A metabolism. She presents with meconium ileus at birth, requiring intestinal resection that led to a transient intestinal failure with parenteral nutrition need. In addition, she suffered from cholestatic liver disease due to CF and intestinal failure-associated liver disease. The interaction of pancreatic function, intestinal absorption and liver storage is fundamental for the correct metabolism of vitamin A. |
format | Online Article Text |
id | pubmed-6723039 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67230392019-09-10 Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System Norsa, Lorenzo Zazzeron, Laura Cuomo, Marialaura Claut, Laura Bulfamante, Anna Marta Clotilde Biffi, Arianna Colombo, Carla Nutrients Communication Vitamin A is a fundamental micronutrient that regulates various cellular patterns. Vitamin A deficiency (VAT) is a worldwide problem and the primary cause of nocturnal blindness especially in low income countries. Cystic fibrosis (CF) is a known risk factor of VAD because of liposoluble vitamin malabsorption due to pancreatic insufficiency. We describe a case of a 9-year-old girl who experienced recurrent episodes of nocturnal blindness due to profound VAD. This little girl is paradigmatic for the explanation of the key role of the gut–liver axis in vitamin A metabolism. She presents with meconium ileus at birth, requiring intestinal resection that led to a transient intestinal failure with parenteral nutrition need. In addition, she suffered from cholestatic liver disease due to CF and intestinal failure-associated liver disease. The interaction of pancreatic function, intestinal absorption and liver storage is fundamental for the correct metabolism of vitamin A. MDPI 2019-08-13 /pmc/articles/PMC6723039/ /pubmed/31412557 http://dx.doi.org/10.3390/nu11081876 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Norsa, Lorenzo Zazzeron, Laura Cuomo, Marialaura Claut, Laura Bulfamante, Anna Marta Clotilde Biffi, Arianna Colombo, Carla Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System |
title | Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System |
title_full | Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System |
title_fullStr | Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System |
title_full_unstemmed | Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System |
title_short | Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System |
title_sort | night blindness in cystic fibrosis: the key role of vitamin a in the digestive system |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723039/ https://www.ncbi.nlm.nih.gov/pubmed/31412557 http://dx.doi.org/10.3390/nu11081876 |
work_keys_str_mv | AT norsalorenzo nightblindnessincysticfibrosisthekeyroleofvitaminainthedigestivesystem AT zazzeronlaura nightblindnessincysticfibrosisthekeyroleofvitaminainthedigestivesystem AT cuomomarialaura nightblindnessincysticfibrosisthekeyroleofvitaminainthedigestivesystem AT clautlaura nightblindnessincysticfibrosisthekeyroleofvitaminainthedigestivesystem AT bulfamanteannamartaclotilde nightblindnessincysticfibrosisthekeyroleofvitaminainthedigestivesystem AT biffiarianna nightblindnessincysticfibrosisthekeyroleofvitaminainthedigestivesystem AT colombocarla nightblindnessincysticfibrosisthekeyroleofvitaminainthedigestivesystem |