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Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System

Vitamin A is a fundamental micronutrient that regulates various cellular patterns. Vitamin A deficiency (VAT) is a worldwide problem and the primary cause of nocturnal blindness especially in low income countries. Cystic fibrosis (CF) is a known risk factor of VAD because of liposoluble vitamin mala...

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Autores principales: Norsa, Lorenzo, Zazzeron, Laura, Cuomo, Marialaura, Claut, Laura, Bulfamante, Anna Marta Clotilde, Biffi, Arianna, Colombo, Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723039/
https://www.ncbi.nlm.nih.gov/pubmed/31412557
http://dx.doi.org/10.3390/nu11081876
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author Norsa, Lorenzo
Zazzeron, Laura
Cuomo, Marialaura
Claut, Laura
Bulfamante, Anna Marta Clotilde
Biffi, Arianna
Colombo, Carla
author_facet Norsa, Lorenzo
Zazzeron, Laura
Cuomo, Marialaura
Claut, Laura
Bulfamante, Anna Marta Clotilde
Biffi, Arianna
Colombo, Carla
author_sort Norsa, Lorenzo
collection PubMed
description Vitamin A is a fundamental micronutrient that regulates various cellular patterns. Vitamin A deficiency (VAT) is a worldwide problem and the primary cause of nocturnal blindness especially in low income countries. Cystic fibrosis (CF) is a known risk factor of VAD because of liposoluble vitamin malabsorption due to pancreatic insufficiency. We describe a case of a 9-year-old girl who experienced recurrent episodes of nocturnal blindness due to profound VAD. This little girl is paradigmatic for the explanation of the key role of the gut–liver axis in vitamin A metabolism. She presents with meconium ileus at birth, requiring intestinal resection that led to a transient intestinal failure with parenteral nutrition need. In addition, she suffered from cholestatic liver disease due to CF and intestinal failure-associated liver disease. The interaction of pancreatic function, intestinal absorption and liver storage is fundamental for the correct metabolism of vitamin A.
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spelling pubmed-67230392019-09-10 Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System Norsa, Lorenzo Zazzeron, Laura Cuomo, Marialaura Claut, Laura Bulfamante, Anna Marta Clotilde Biffi, Arianna Colombo, Carla Nutrients Communication Vitamin A is a fundamental micronutrient that regulates various cellular patterns. Vitamin A deficiency (VAT) is a worldwide problem and the primary cause of nocturnal blindness especially in low income countries. Cystic fibrosis (CF) is a known risk factor of VAD because of liposoluble vitamin malabsorption due to pancreatic insufficiency. We describe a case of a 9-year-old girl who experienced recurrent episodes of nocturnal blindness due to profound VAD. This little girl is paradigmatic for the explanation of the key role of the gut–liver axis in vitamin A metabolism. She presents with meconium ileus at birth, requiring intestinal resection that led to a transient intestinal failure with parenteral nutrition need. In addition, she suffered from cholestatic liver disease due to CF and intestinal failure-associated liver disease. The interaction of pancreatic function, intestinal absorption and liver storage is fundamental for the correct metabolism of vitamin A. MDPI 2019-08-13 /pmc/articles/PMC6723039/ /pubmed/31412557 http://dx.doi.org/10.3390/nu11081876 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Norsa, Lorenzo
Zazzeron, Laura
Cuomo, Marialaura
Claut, Laura
Bulfamante, Anna Marta Clotilde
Biffi, Arianna
Colombo, Carla
Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System
title Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System
title_full Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System
title_fullStr Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System
title_full_unstemmed Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System
title_short Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System
title_sort night blindness in cystic fibrosis: the key role of vitamin a in the digestive system
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723039/
https://www.ncbi.nlm.nih.gov/pubmed/31412557
http://dx.doi.org/10.3390/nu11081876
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