Detection of TP53 and PIK3CA Mutations in Circulating Tumor DNA Using Next-Generation Sequencing in the Screening Process for Early Breast Cancer Diagnosis

Circulating tumor DNA (ctDNA) has emerged as a non-invasive “liquid biopsy” for early breast cancer diagnosis. We evaluated the suitability of ctDNA analysis in the diagnosis of early breast cancer after mammography findings, comparing PIK3CA and TP53 mutations between tumor biopsies and pre-biopsy...

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Detalles Bibliográficos
Autores principales: Jimenez Rodriguez, Begona, Diaz Córdoba, Gema, Garrido Aranda, Alicia, Álvarez, Martina, Vicioso, Luis, Llácer Pérez, Casilda, Hernando, Cristina, Bermejo, Begoña, Julve Parreño, Ana, Lluch, Ana, Ryder, Matthew B., Jones, Frederick S., Fredebohm, Johannes, Holtrup, Frank, Queipo-Ortuño, María Isabel, Alba, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723048/
https://www.ncbi.nlm.nih.gov/pubmed/31394872
http://dx.doi.org/10.3390/jcm8081183

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