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Caucasian Ethnicity, but Not Treatment Cessation Is Associated with HBsAg Loss Following Nucleos(t)ide Analogue-Induced HBeAg Seroconversion

It is well appreciated that ethnicity influences the natural history and immune responses during a chronic hepatitis B infection. In this study, we explore the effect of ethnicity and treatment cessation on Hepatitis B surface Antigen (HBsAg) seroclearance in patients with Nucleos(t)ide Analogue (NA...

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Autores principales: Van Hees, Stijn, Chi, Heng, Hansen, Bettina, Bourgeois, Stefan, Van Vlierberghe, Hans, Sersté, Thomas, Francque, Sven, Wong, David, Sprengers, Dirk, Moreno, Christophe, Nevens, Frederik, Janssen, Harry, Vanwolleghem, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723144/
https://www.ncbi.nlm.nih.gov/pubmed/31357522
http://dx.doi.org/10.3390/v11080687
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author Van Hees, Stijn
Chi, Heng
Hansen, Bettina
Bourgeois, Stefan
Van Vlierberghe, Hans
Sersté, Thomas
Francque, Sven
Wong, David
Sprengers, Dirk
Moreno, Christophe
Nevens, Frederik
Janssen, Harry
Vanwolleghem, Thomas
author_facet Van Hees, Stijn
Chi, Heng
Hansen, Bettina
Bourgeois, Stefan
Van Vlierberghe, Hans
Sersté, Thomas
Francque, Sven
Wong, David
Sprengers, Dirk
Moreno, Christophe
Nevens, Frederik
Janssen, Harry
Vanwolleghem, Thomas
author_sort Van Hees, Stijn
collection PubMed
description It is well appreciated that ethnicity influences the natural history and immune responses during a chronic hepatitis B infection. In this study, we explore the effect of ethnicity and treatment cessation on Hepatitis B surface Antigen (HBsAg) seroclearance in patients with Nucleos(t)ide Analogue (NA)-induced Hepatitis B e Antigen (HBeAg) seroconversion. We performed a multi-ethnic, multicentric observational cohort study. The analyzed cohort consisted of 178 mono-infected, predominantly male (75.3%) chronic hepatitis B patients of mixed ethnicity (44.4% Asians, 48.9% Caucasians) with nucleos(t)ide analogue-induced HBeAg seroconversion. Treatment was withdrawn in 105 patients and continued in 73, leading to HBsAg loss in 14 patients off- and 16 patients on-treatment, respectively. Overall, HBsAg loss rates were not affected by treatment cessation (hazard ratio 1.45, p = 0.372), regardless of consolidation treatment duration. Caucasian ethnicity was associated with an increased chance of HBsAg loss (hazard ratio 6.70, p = 0.001), but hepatitis B virus genotype was not (p = 0.812). In conclusion, ethnicity is the most important determinant for HBsAg loss after NA-induced HBeAg seroconversion, with up to six-fold higher HBsAg loss rates in Caucasians compared to Asians, irrespective of treatment cessation and consolidation treatment duration.
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spelling pubmed-67231442019-09-10 Caucasian Ethnicity, but Not Treatment Cessation Is Associated with HBsAg Loss Following Nucleos(t)ide Analogue-Induced HBeAg Seroconversion Van Hees, Stijn Chi, Heng Hansen, Bettina Bourgeois, Stefan Van Vlierberghe, Hans Sersté, Thomas Francque, Sven Wong, David Sprengers, Dirk Moreno, Christophe Nevens, Frederik Janssen, Harry Vanwolleghem, Thomas Viruses Article It is well appreciated that ethnicity influences the natural history and immune responses during a chronic hepatitis B infection. In this study, we explore the effect of ethnicity and treatment cessation on Hepatitis B surface Antigen (HBsAg) seroclearance in patients with Nucleos(t)ide Analogue (NA)-induced Hepatitis B e Antigen (HBeAg) seroconversion. We performed a multi-ethnic, multicentric observational cohort study. The analyzed cohort consisted of 178 mono-infected, predominantly male (75.3%) chronic hepatitis B patients of mixed ethnicity (44.4% Asians, 48.9% Caucasians) with nucleos(t)ide analogue-induced HBeAg seroconversion. Treatment was withdrawn in 105 patients and continued in 73, leading to HBsAg loss in 14 patients off- and 16 patients on-treatment, respectively. Overall, HBsAg loss rates were not affected by treatment cessation (hazard ratio 1.45, p = 0.372), regardless of consolidation treatment duration. Caucasian ethnicity was associated with an increased chance of HBsAg loss (hazard ratio 6.70, p = 0.001), but hepatitis B virus genotype was not (p = 0.812). In conclusion, ethnicity is the most important determinant for HBsAg loss after NA-induced HBeAg seroconversion, with up to six-fold higher HBsAg loss rates in Caucasians compared to Asians, irrespective of treatment cessation and consolidation treatment duration. MDPI 2019-07-26 /pmc/articles/PMC6723144/ /pubmed/31357522 http://dx.doi.org/10.3390/v11080687 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Van Hees, Stijn
Chi, Heng
Hansen, Bettina
Bourgeois, Stefan
Van Vlierberghe, Hans
Sersté, Thomas
Francque, Sven
Wong, David
Sprengers, Dirk
Moreno, Christophe
Nevens, Frederik
Janssen, Harry
Vanwolleghem, Thomas
Caucasian Ethnicity, but Not Treatment Cessation Is Associated with HBsAg Loss Following Nucleos(t)ide Analogue-Induced HBeAg Seroconversion
title Caucasian Ethnicity, but Not Treatment Cessation Is Associated with HBsAg Loss Following Nucleos(t)ide Analogue-Induced HBeAg Seroconversion
title_full Caucasian Ethnicity, but Not Treatment Cessation Is Associated with HBsAg Loss Following Nucleos(t)ide Analogue-Induced HBeAg Seroconversion
title_fullStr Caucasian Ethnicity, but Not Treatment Cessation Is Associated with HBsAg Loss Following Nucleos(t)ide Analogue-Induced HBeAg Seroconversion
title_full_unstemmed Caucasian Ethnicity, but Not Treatment Cessation Is Associated with HBsAg Loss Following Nucleos(t)ide Analogue-Induced HBeAg Seroconversion
title_short Caucasian Ethnicity, but Not Treatment Cessation Is Associated with HBsAg Loss Following Nucleos(t)ide Analogue-Induced HBeAg Seroconversion
title_sort caucasian ethnicity, but not treatment cessation is associated with hbsag loss following nucleos(t)ide analogue-induced hbeag seroconversion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723144/
https://www.ncbi.nlm.nih.gov/pubmed/31357522
http://dx.doi.org/10.3390/v11080687
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