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Consumption of Nutrition Supplements Is Associated with Less Hypoglycemia during Admission—Results from the MENU Project

Aim: We studied the effect of the addition of an oral nutrition supplement (ONS) on the rate of hypoglyemia among hospitalized type 2 diabetes mellitus (DM) patients. Methods: In this retrospective analysis, all DM patients with hypoalbuminemia (albumin < 3.5 g/dL) admitted to internal medicine “...

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Autores principales: Leibovitz, Eyal, Moore, Fariba, Mintser, Irina, Levi, Anat, Dubinsky, Ron, Boaz, Mona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723161/
https://www.ncbi.nlm.nih.gov/pubmed/31398808
http://dx.doi.org/10.3390/nu11081832
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author Leibovitz, Eyal
Moore, Fariba
Mintser, Irina
Levi, Anat
Dubinsky, Ron
Boaz, Mona
author_facet Leibovitz, Eyal
Moore, Fariba
Mintser, Irina
Levi, Anat
Dubinsky, Ron
Boaz, Mona
author_sort Leibovitz, Eyal
collection PubMed
description Aim: We studied the effect of the addition of an oral nutrition supplement (ONS) on the rate of hypoglyemia among hospitalized type 2 diabetes mellitus (DM) patients. Methods: In this retrospective analysis, all DM patients with hypoalbuminemia (albumin < 3.5 g/dL) admitted to internal medicine “E” at Wolfson Medical Center between 1 June 2016 and 30 April 2017 were included. One bottle of ONS (Glucerna, 330 KCAL, 28 g carbohydrates, 17 g protein, 17 g fat) was added to the morning meal. The consumption of the ONS was verified during the morning rounds. All glucose measurements were recorded automatically in the patients’ electronic medical records. A logistic regression model was used to evaluate the effect of the nutrition support on the occurrence of hypoglycemia. Results: 218 patients (mean age 77.4 ± 12.0 years, 63.3% female, mean albumin 3.13 ± 0.32 g/dL), of whom 27.9% had documented hypoglycemia during hospitalization were included. The patients consumed 69.5% ± 37.1 of the ONS provided, and ONS was started 4.3 ± 5.3 days from admission. A logistic regression model indicated that age (Odds ratio [OR] 1.048, 95% CI 1.014–1.083, p = 0.005), insulin treatment (OR 3.059, 95% CI 1.497–6.251, p = 0.002), and the day of ONS started from admission (OR 1.094, 95% CI 1.021–1.173, p = 0.011) were associated with an increased risk of hypoglycemia. Complete consumption of the ONS was associated with a reduced risk of hypoglycemia: OR 0.364, 95% CI 0.149–0.890, p = 0.027. Age, other DM medications and serum albumin did not affect the risk. Conclusion: The intake of a complete serving of ONS may be associated with a reduction of the risk of hypoglycemia among diabetes in-patients with hypoalbuminemia.
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spelling pubmed-67231612019-09-10 Consumption of Nutrition Supplements Is Associated with Less Hypoglycemia during Admission—Results from the MENU Project Leibovitz, Eyal Moore, Fariba Mintser, Irina Levi, Anat Dubinsky, Ron Boaz, Mona Nutrients Article Aim: We studied the effect of the addition of an oral nutrition supplement (ONS) on the rate of hypoglyemia among hospitalized type 2 diabetes mellitus (DM) patients. Methods: In this retrospective analysis, all DM patients with hypoalbuminemia (albumin < 3.5 g/dL) admitted to internal medicine “E” at Wolfson Medical Center between 1 June 2016 and 30 April 2017 were included. One bottle of ONS (Glucerna, 330 KCAL, 28 g carbohydrates, 17 g protein, 17 g fat) was added to the morning meal. The consumption of the ONS was verified during the morning rounds. All glucose measurements were recorded automatically in the patients’ electronic medical records. A logistic regression model was used to evaluate the effect of the nutrition support on the occurrence of hypoglycemia. Results: 218 patients (mean age 77.4 ± 12.0 years, 63.3% female, mean albumin 3.13 ± 0.32 g/dL), of whom 27.9% had documented hypoglycemia during hospitalization were included. The patients consumed 69.5% ± 37.1 of the ONS provided, and ONS was started 4.3 ± 5.3 days from admission. A logistic regression model indicated that age (Odds ratio [OR] 1.048, 95% CI 1.014–1.083, p = 0.005), insulin treatment (OR 3.059, 95% CI 1.497–6.251, p = 0.002), and the day of ONS started from admission (OR 1.094, 95% CI 1.021–1.173, p = 0.011) were associated with an increased risk of hypoglycemia. Complete consumption of the ONS was associated with a reduced risk of hypoglycemia: OR 0.364, 95% CI 0.149–0.890, p = 0.027. Age, other DM medications and serum albumin did not affect the risk. Conclusion: The intake of a complete serving of ONS may be associated with a reduction of the risk of hypoglycemia among diabetes in-patients with hypoalbuminemia. MDPI 2019-08-08 /pmc/articles/PMC6723161/ /pubmed/31398808 http://dx.doi.org/10.3390/nu11081832 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Leibovitz, Eyal
Moore, Fariba
Mintser, Irina
Levi, Anat
Dubinsky, Ron
Boaz, Mona
Consumption of Nutrition Supplements Is Associated with Less Hypoglycemia during Admission—Results from the MENU Project
title Consumption of Nutrition Supplements Is Associated with Less Hypoglycemia during Admission—Results from the MENU Project
title_full Consumption of Nutrition Supplements Is Associated with Less Hypoglycemia during Admission—Results from the MENU Project
title_fullStr Consumption of Nutrition Supplements Is Associated with Less Hypoglycemia during Admission—Results from the MENU Project
title_full_unstemmed Consumption of Nutrition Supplements Is Associated with Less Hypoglycemia during Admission—Results from the MENU Project
title_short Consumption of Nutrition Supplements Is Associated with Less Hypoglycemia during Admission—Results from the MENU Project
title_sort consumption of nutrition supplements is associated with less hypoglycemia during admission—results from the menu project
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723161/
https://www.ncbi.nlm.nih.gov/pubmed/31398808
http://dx.doi.org/10.3390/nu11081832
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