Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11

Overexpression of the global regulator LaeA in a marine-derived fungal strain of Penicillium dipodomyis YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-di...

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Autores principales: Yu, Jing, Han, Huan, Zhang, Xianyan, Ma, Chuanteng, Sun, Chunxiao, Che, Qian, Gu, Qianqun, Zhu, Tianjiao, Zhang, Guojian, Li, Dehai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723206/
https://www.ncbi.nlm.nih.gov/pubmed/31357680
http://dx.doi.org/10.3390/md17080446
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author Yu, Jing
Han, Huan
Zhang, Xianyan
Ma, Chuanteng
Sun, Chunxiao
Che, Qian
Gu, Qianqun
Zhu, Tianjiao
Zhang, Guojian
Li, Dehai
author_facet Yu, Jing
Han, Huan
Zhang, Xianyan
Ma, Chuanteng
Sun, Chunxiao
Che, Qian
Gu, Qianqun
Zhu, Tianjiao
Zhang, Guojian
Li, Dehai
author_sort Yu, Jing
collection PubMed
description Overexpression of the global regulator LaeA in a marine-derived fungal strain of Penicillium dipodomyis YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-dihydrobislongiquinolide (1) and 10,11,16,17-tetrahydrobislongiquinolide (2), as well as four known analogues, bislongiquinolide (3), 16,17-dihydrobislongiquinolide (4), sohirnone A (5), and 2′,3′-dihydrosorbicillin (6). The results support that the global regulator LaeA is a useful tool in activating silent gene clusters in Penicillium strains to obtain previously undiscovered compounds.
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spelling pubmed-67232062019-09-10 Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11 Yu, Jing Han, Huan Zhang, Xianyan Ma, Chuanteng Sun, Chunxiao Che, Qian Gu, Qianqun Zhu, Tianjiao Zhang, Guojian Li, Dehai Mar Drugs Article Overexpression of the global regulator LaeA in a marine-derived fungal strain of Penicillium dipodomyis YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-dihydrobislongiquinolide (1) and 10,11,16,17-tetrahydrobislongiquinolide (2), as well as four known analogues, bislongiquinolide (3), 16,17-dihydrobislongiquinolide (4), sohirnone A (5), and 2′,3′-dihydrosorbicillin (6). The results support that the global regulator LaeA is a useful tool in activating silent gene clusters in Penicillium strains to obtain previously undiscovered compounds. MDPI 2019-07-28 /pmc/articles/PMC6723206/ /pubmed/31357680 http://dx.doi.org/10.3390/md17080446 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yu, Jing
Han, Huan
Zhang, Xianyan
Ma, Chuanteng
Sun, Chunxiao
Che, Qian
Gu, Qianqun
Zhu, Tianjiao
Zhang, Guojian
Li, Dehai
Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11
title Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11
title_full Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11
title_fullStr Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11
title_full_unstemmed Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11
title_short Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11
title_sort discovery of two new sorbicillinoids by overexpression of the global regulator laea in a marine-derived fungus penicillium dipodomyis yj-11
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723206/
https://www.ncbi.nlm.nih.gov/pubmed/31357680
http://dx.doi.org/10.3390/md17080446
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