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Wild Nutria (Myocastor coypus) Is a Potential Reservoir of Carbapenem-Resistant and Zoonotic Aeromonas spp. in Korea

The emergence and spread of antibiotic-resistant Aeromonas spp. is a serious public and animal health concern. Wild animals serve as reservoirs, vectors, and sentinels of these bacteria and can facilitate their transmission to humans and livestock. The nutria (Myocastor coypus), a semi-aquatic roden...

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Autores principales: Lim, Se Ra, Lee, Do-Hun, Park, Seon Young, Lee, Seungki, Kim, Hyo Yeon, Lee, Moo-Seung, Lee, Jung Ro, Han, Jee Eun, Kim, Hye Kwon, Kim, Ji Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723217/
https://www.ncbi.nlm.nih.gov/pubmed/31366125
http://dx.doi.org/10.3390/microorganisms7080224
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author Lim, Se Ra
Lee, Do-Hun
Park, Seon Young
Lee, Seungki
Kim, Hyo Yeon
Lee, Moo-Seung
Lee, Jung Ro
Han, Jee Eun
Kim, Hye Kwon
Kim, Ji Hyung
author_facet Lim, Se Ra
Lee, Do-Hun
Park, Seon Young
Lee, Seungki
Kim, Hyo Yeon
Lee, Moo-Seung
Lee, Jung Ro
Han, Jee Eun
Kim, Hye Kwon
Kim, Ji Hyung
author_sort Lim, Se Ra
collection PubMed
description The emergence and spread of antibiotic-resistant Aeromonas spp. is a serious public and animal health concern. Wild animals serve as reservoirs, vectors, and sentinels of these bacteria and can facilitate their transmission to humans and livestock. The nutria (Myocastor coypus), a semi-aquatic rodent, currently is globally considered an invasive alien species that has harmful impacts on natural ecosystems and carries various zoonotic aquatic pathogens. This study aimed to determine the prevalence of antibiotic-resistant zoonotic Aeromonas spp. in wild invasive nutrias captured in Korea during governmental eradication program. Three potential zoonotic Aeromonas spp. (A. hydrophila, A. caviae, and A. dhakensis) were identified among isolates from nutria. Some strains showed unexpected resistance to fluoroquinolones, third-generation cephalosporins, and carbapenems. In carbapenem-resistant isolates, the cphA gene, which is related to intrinsic resistance of Aeromonas to carbapenems, was identified, and phylogenetic analysis based on this gene revealed the presence of two major groups represented by A. hydrophila (including A. dhakensis) and other Aeromonas spp. These results indicate that wild nutrias in Korea are a potential reservoir of zoonotic and antibiotic-resistant Aeromonas spp. that can cause infection and treatment failure in humans. Thus, measures to prevent contact of wild nutrias with livestock and humans are needed.
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spelling pubmed-67232172019-09-10 Wild Nutria (Myocastor coypus) Is a Potential Reservoir of Carbapenem-Resistant and Zoonotic Aeromonas spp. in Korea Lim, Se Ra Lee, Do-Hun Park, Seon Young Lee, Seungki Kim, Hyo Yeon Lee, Moo-Seung Lee, Jung Ro Han, Jee Eun Kim, Hye Kwon Kim, Ji Hyung Microorganisms Article The emergence and spread of antibiotic-resistant Aeromonas spp. is a serious public and animal health concern. Wild animals serve as reservoirs, vectors, and sentinels of these bacteria and can facilitate their transmission to humans and livestock. The nutria (Myocastor coypus), a semi-aquatic rodent, currently is globally considered an invasive alien species that has harmful impacts on natural ecosystems and carries various zoonotic aquatic pathogens. This study aimed to determine the prevalence of antibiotic-resistant zoonotic Aeromonas spp. in wild invasive nutrias captured in Korea during governmental eradication program. Three potential zoonotic Aeromonas spp. (A. hydrophila, A. caviae, and A. dhakensis) were identified among isolates from nutria. Some strains showed unexpected resistance to fluoroquinolones, third-generation cephalosporins, and carbapenems. In carbapenem-resistant isolates, the cphA gene, which is related to intrinsic resistance of Aeromonas to carbapenems, was identified, and phylogenetic analysis based on this gene revealed the presence of two major groups represented by A. hydrophila (including A. dhakensis) and other Aeromonas spp. These results indicate that wild nutrias in Korea are a potential reservoir of zoonotic and antibiotic-resistant Aeromonas spp. that can cause infection and treatment failure in humans. Thus, measures to prevent contact of wild nutrias with livestock and humans are needed. MDPI 2019-07-30 /pmc/articles/PMC6723217/ /pubmed/31366125 http://dx.doi.org/10.3390/microorganisms7080224 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lim, Se Ra
Lee, Do-Hun
Park, Seon Young
Lee, Seungki
Kim, Hyo Yeon
Lee, Moo-Seung
Lee, Jung Ro
Han, Jee Eun
Kim, Hye Kwon
Kim, Ji Hyung
Wild Nutria (Myocastor coypus) Is a Potential Reservoir of Carbapenem-Resistant and Zoonotic Aeromonas spp. in Korea
title Wild Nutria (Myocastor coypus) Is a Potential Reservoir of Carbapenem-Resistant and Zoonotic Aeromonas spp. in Korea
title_full Wild Nutria (Myocastor coypus) Is a Potential Reservoir of Carbapenem-Resistant and Zoonotic Aeromonas spp. in Korea
title_fullStr Wild Nutria (Myocastor coypus) Is a Potential Reservoir of Carbapenem-Resistant and Zoonotic Aeromonas spp. in Korea
title_full_unstemmed Wild Nutria (Myocastor coypus) Is a Potential Reservoir of Carbapenem-Resistant and Zoonotic Aeromonas spp. in Korea
title_short Wild Nutria (Myocastor coypus) Is a Potential Reservoir of Carbapenem-Resistant and Zoonotic Aeromonas spp. in Korea
title_sort wild nutria (myocastor coypus) is a potential reservoir of carbapenem-resistant and zoonotic aeromonas spp. in korea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723217/
https://www.ncbi.nlm.nih.gov/pubmed/31366125
http://dx.doi.org/10.3390/microorganisms7080224
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