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The Impact of Metabolic Syndrome on the Incidence of Atrial Fibrillation: A Nationwide Longitudinal Cohort Study in South Korea

Aims: To evaluate the impact of metabolic syndrome (MetS) status on the incidence of atrial fibrillation (AF) in Koreans. Methods and results: Data obtained from the Korean National Health Insurance Service from 2009 to 2016 were analyzed. In total, 7,830,602 men and women (between 30 and 69 years o...

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Autores principales: Kwon, Chang Hee, Kim, Hyeongsu, Kim, Sung Hea, Kim, Bum Sung, Kim, Hyun-Joong, Sung, Ji Dong, Kim, Duk-Kyung, Han, Seong Woo, Ryu, Kyu-Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723247/
https://www.ncbi.nlm.nih.gov/pubmed/31344944
http://dx.doi.org/10.3390/jcm8081095
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author Kwon, Chang Hee
Kim, Hyeongsu
Kim, Sung Hea
Kim, Bum Sung
Kim, Hyun-Joong
Sung, Ji Dong
Kim, Duk-Kyung
Han, Seong Woo
Ryu, Kyu-Hyung
author_facet Kwon, Chang Hee
Kim, Hyeongsu
Kim, Sung Hea
Kim, Bum Sung
Kim, Hyun-Joong
Sung, Ji Dong
Kim, Duk-Kyung
Han, Seong Woo
Ryu, Kyu-Hyung
author_sort Kwon, Chang Hee
collection PubMed
description Aims: To evaluate the impact of metabolic syndrome (MetS) status on the incidence of atrial fibrillation (AF) in Koreans. Methods and results: Data obtained from the Korean National Health Insurance Service from 2009 to 2016 were analyzed. In total, 7,830,602 men and women (between 30 and 69 years of age) without baseline AF who underwent a national health examination between January 2009 and December 2009 were enrolled. Patients were evaluated to determine the impact of MetS status on their risk of developing AF until December 2016. Using the National Cholesterol Education Program Adult Treatment Panel III criteria, patients were placed into one of three groups depending on MetS component numbers: 0 (normal), 1–2 (Pre-MetS) or 3–5 (MetS). During a mean follow-up of 7.3 years, 20,708 subjects (0.26%) were diagnosed with AF. After multivariable adjustment, the risk of AF was significantly and positively correlated with MetS status (hazard ratios (HR) 1.391, 95% confidence interval (CI) 1.322–1.464 in Pre-MetS and HR 1.722, 95% CI 1.621–1.829 in MetS). When subgroup analyses were conducted according to MetS components, abdominal obesity (HR 1.316, p < 0.001), elevated blood pressure (HR 1.451, p < 0.001), and elevated fasting glucose (HR 1.163, p < 0.001) were associated with an increased risk of AF. Conclusion: MetS and pre-MetS are significantly associated with an increased risk of AF in Korean adults. Of the MetS components, abdominal obesity, elevated blood pressure, and elevated fasting glucose are potent risk factors for the risk of AF in this population.
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spelling pubmed-67232472019-09-10 The Impact of Metabolic Syndrome on the Incidence of Atrial Fibrillation: A Nationwide Longitudinal Cohort Study in South Korea Kwon, Chang Hee Kim, Hyeongsu Kim, Sung Hea Kim, Bum Sung Kim, Hyun-Joong Sung, Ji Dong Kim, Duk-Kyung Han, Seong Woo Ryu, Kyu-Hyung J Clin Med Article Aims: To evaluate the impact of metabolic syndrome (MetS) status on the incidence of atrial fibrillation (AF) in Koreans. Methods and results: Data obtained from the Korean National Health Insurance Service from 2009 to 2016 were analyzed. In total, 7,830,602 men and women (between 30 and 69 years of age) without baseline AF who underwent a national health examination between January 2009 and December 2009 were enrolled. Patients were evaluated to determine the impact of MetS status on their risk of developing AF until December 2016. Using the National Cholesterol Education Program Adult Treatment Panel III criteria, patients were placed into one of three groups depending on MetS component numbers: 0 (normal), 1–2 (Pre-MetS) or 3–5 (MetS). During a mean follow-up of 7.3 years, 20,708 subjects (0.26%) were diagnosed with AF. After multivariable adjustment, the risk of AF was significantly and positively correlated with MetS status (hazard ratios (HR) 1.391, 95% confidence interval (CI) 1.322–1.464 in Pre-MetS and HR 1.722, 95% CI 1.621–1.829 in MetS). When subgroup analyses were conducted according to MetS components, abdominal obesity (HR 1.316, p < 0.001), elevated blood pressure (HR 1.451, p < 0.001), and elevated fasting glucose (HR 1.163, p < 0.001) were associated with an increased risk of AF. Conclusion: MetS and pre-MetS are significantly associated with an increased risk of AF in Korean adults. Of the MetS components, abdominal obesity, elevated blood pressure, and elevated fasting glucose are potent risk factors for the risk of AF in this population. MDPI 2019-07-24 /pmc/articles/PMC6723247/ /pubmed/31344944 http://dx.doi.org/10.3390/jcm8081095 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kwon, Chang Hee
Kim, Hyeongsu
Kim, Sung Hea
Kim, Bum Sung
Kim, Hyun-Joong
Sung, Ji Dong
Kim, Duk-Kyung
Han, Seong Woo
Ryu, Kyu-Hyung
The Impact of Metabolic Syndrome on the Incidence of Atrial Fibrillation: A Nationwide Longitudinal Cohort Study in South Korea
title The Impact of Metabolic Syndrome on the Incidence of Atrial Fibrillation: A Nationwide Longitudinal Cohort Study in South Korea
title_full The Impact of Metabolic Syndrome on the Incidence of Atrial Fibrillation: A Nationwide Longitudinal Cohort Study in South Korea
title_fullStr The Impact of Metabolic Syndrome on the Incidence of Atrial Fibrillation: A Nationwide Longitudinal Cohort Study in South Korea
title_full_unstemmed The Impact of Metabolic Syndrome on the Incidence of Atrial Fibrillation: A Nationwide Longitudinal Cohort Study in South Korea
title_short The Impact of Metabolic Syndrome on the Incidence of Atrial Fibrillation: A Nationwide Longitudinal Cohort Study in South Korea
title_sort impact of metabolic syndrome on the incidence of atrial fibrillation: a nationwide longitudinal cohort study in south korea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723247/
https://www.ncbi.nlm.nih.gov/pubmed/31344944
http://dx.doi.org/10.3390/jcm8081095
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