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BMP-2 Gene Delivery-Based Bone Regeneration in Dentistry

Bone morphogenetic protein-2 (BMP-2) is a potent growth factor affecting bone formation. While recombinant human BMP-2 (rhBMP-2) has been commercially available in cases of non-union fracture and spinal fusion in orthopaedics, it has also been applied to improve bone regeneration in challenging case...

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Autores principales: Park, Shin-Young, Kim, Kyoung-Hwa, Kim, Sungtae, Lee, Yong-Moo, Seol, Yang-Jo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723260/
https://www.ncbi.nlm.nih.gov/pubmed/31387267
http://dx.doi.org/10.3390/pharmaceutics11080393
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author Park, Shin-Young
Kim, Kyoung-Hwa
Kim, Sungtae
Lee, Yong-Moo
Seol, Yang-Jo
author_facet Park, Shin-Young
Kim, Kyoung-Hwa
Kim, Sungtae
Lee, Yong-Moo
Seol, Yang-Jo
author_sort Park, Shin-Young
collection PubMed
description Bone morphogenetic protein-2 (BMP-2) is a potent growth factor affecting bone formation. While recombinant human BMP-2 (rhBMP-2) has been commercially available in cases of non-union fracture and spinal fusion in orthopaedics, it has also been applied to improve bone regeneration in challenging cases requiring dental implant treatment. However, complications related to an initially high dosage for maintaining an effective physiological concentration at the defect site have been reported, although an effective and safe rhBMP-2 dosage for bone regeneration has not yet been determined. In contrast to protein delivery, BMP-2 gene transfer into the defect site induces BMP-2 synthesis in vivo and leads to secretion for weeks to months, depending on the vector, at a concentration of nanograms per milliliter. BMP-2 gene delivery is advantageous for bone wound healing process in terms of dosage and duration. However, safety concerns related to viral vectors are one of the hurdles that need to be overcome for gene delivery to be used in clinical practice. Recently, commercially available gene therapy has been introduced in orthopedics, and clinical trials in dentistry have been ongoing. This review examines the application of BMP-2 gene therapy for bone regeneration in the oral and maxillofacial regions and discusses future perspectives of BMP-2 gene therapy in dentistry.
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spelling pubmed-67232602019-09-10 BMP-2 Gene Delivery-Based Bone Regeneration in Dentistry Park, Shin-Young Kim, Kyoung-Hwa Kim, Sungtae Lee, Yong-Moo Seol, Yang-Jo Pharmaceutics Review Bone morphogenetic protein-2 (BMP-2) is a potent growth factor affecting bone formation. While recombinant human BMP-2 (rhBMP-2) has been commercially available in cases of non-union fracture and spinal fusion in orthopaedics, it has also been applied to improve bone regeneration in challenging cases requiring dental implant treatment. However, complications related to an initially high dosage for maintaining an effective physiological concentration at the defect site have been reported, although an effective and safe rhBMP-2 dosage for bone regeneration has not yet been determined. In contrast to protein delivery, BMP-2 gene transfer into the defect site induces BMP-2 synthesis in vivo and leads to secretion for weeks to months, depending on the vector, at a concentration of nanograms per milliliter. BMP-2 gene delivery is advantageous for bone wound healing process in terms of dosage and duration. However, safety concerns related to viral vectors are one of the hurdles that need to be overcome for gene delivery to be used in clinical practice. Recently, commercially available gene therapy has been introduced in orthopedics, and clinical trials in dentistry have been ongoing. This review examines the application of BMP-2 gene therapy for bone regeneration in the oral and maxillofacial regions and discusses future perspectives of BMP-2 gene therapy in dentistry. MDPI 2019-08-05 /pmc/articles/PMC6723260/ /pubmed/31387267 http://dx.doi.org/10.3390/pharmaceutics11080393 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Park, Shin-Young
Kim, Kyoung-Hwa
Kim, Sungtae
Lee, Yong-Moo
Seol, Yang-Jo
BMP-2 Gene Delivery-Based Bone Regeneration in Dentistry
title BMP-2 Gene Delivery-Based Bone Regeneration in Dentistry
title_full BMP-2 Gene Delivery-Based Bone Regeneration in Dentistry
title_fullStr BMP-2 Gene Delivery-Based Bone Regeneration in Dentistry
title_full_unstemmed BMP-2 Gene Delivery-Based Bone Regeneration in Dentistry
title_short BMP-2 Gene Delivery-Based Bone Regeneration in Dentistry
title_sort bmp-2 gene delivery-based bone regeneration in dentistry
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723260/
https://www.ncbi.nlm.nih.gov/pubmed/31387267
http://dx.doi.org/10.3390/pharmaceutics11080393
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