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The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1

Stress-induced premature cellular senescence is a significant factor in the onset of age-dependent disease in the cardiovascular system. Plasminogen activator inhibitor-1 (PAI-1), a major TGF-β1/p53 target gene and negative regulator of the plasmin-based pericellular proteolytic cascade, is elevated...

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Detalles Bibliográficos
Autores principales:	Samarakoon, Rohan, Higgins, Stephen P., Higgins, Craig E., Higgins, Paul J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723262/ https://www.ncbi.nlm.nih.gov/pubmed/31382626 http://dx.doi.org/10.3390/biom9080341

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