Cargando…

Treatment Trends in Dry Eye Disease and Factors Associated with Ophthalmic Follow-up Discontinuation in Japan

Despite the importance of dry eye disease (DED) treatment, the rate of DED treatment discontinuation, especially discontinuation of ophthalmic follow-up, remains unknown. This study aimed to assess the prevalence and risk factors of ophthalmic follow-up discontinuation for DED. A cross-sectional sur...

Descripción completa

Detalles Bibliográficos
Autores principales: Uchino, Miki, Yokoi, Norihiko, Kawashima, Motoko, Ryutaro, Yamanishi, Uchino, Yuichi, Tsubota, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723303/
https://www.ncbi.nlm.nih.gov/pubmed/31357696
http://dx.doi.org/10.3390/jcm8081120
_version_ 1783448736625590272
author Uchino, Miki
Yokoi, Norihiko
Kawashima, Motoko
Ryutaro, Yamanishi
Uchino, Yuichi
Tsubota, Kazuo
author_facet Uchino, Miki
Yokoi, Norihiko
Kawashima, Motoko
Ryutaro, Yamanishi
Uchino, Yuichi
Tsubota, Kazuo
author_sort Uchino, Miki
collection PubMed
description Despite the importance of dry eye disease (DED) treatment, the rate of DED treatment discontinuation, especially discontinuation of ophthalmic follow-up, remains unknown. This study aimed to assess the prevalence and risk factors of ophthalmic follow-up discontinuation for DED. A cross-sectional survey of 1030 participants was conducted using a self-administered web-survey instrument. We collected lifestyle information, history of DED diagnosis, types of treatment, frequency of eye-drop usage, symptoms, and the reasons for discontinuing treatment. Statistical analyses including logistic regression were used to evaluate the risk factors of discontinuing ophthalmic follow-up for DED. A past history of clinical DED diagnosis was reported by 155 (15.0%) subjects. Of those, 130 had persistent DED, and 88 (67.7%) of the subjects reported discontinuation of ophthalmic follow-up for DED. The most prevalent reasons for ophthalmic follow-up discontinuation were time restrictions, followed by dissatisfaction with the DED treatment. Duration after DED diagnosis was the only significant risk factor for discontinuing ophthalmic follow-up after adjusting for age and sex (odds ratio = 1.09, 95% confidence interval = 1.02–1.17, p = 0.009). In conclusion, longer DED duration after diagnosis was a significant risk factor for discontinuing ophthalmic follow-up for DED. This study showed that DED ophthalmic follow-up discontinuation involves both medical and non-medical reasons. Clinicians need to be aware of them, and preventative effort is needed to avoid discontinuation.
format Online
Article
Text
id pubmed-6723303
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67233032019-09-10 Treatment Trends in Dry Eye Disease and Factors Associated with Ophthalmic Follow-up Discontinuation in Japan Uchino, Miki Yokoi, Norihiko Kawashima, Motoko Ryutaro, Yamanishi Uchino, Yuichi Tsubota, Kazuo J Clin Med Article Despite the importance of dry eye disease (DED) treatment, the rate of DED treatment discontinuation, especially discontinuation of ophthalmic follow-up, remains unknown. This study aimed to assess the prevalence and risk factors of ophthalmic follow-up discontinuation for DED. A cross-sectional survey of 1030 participants was conducted using a self-administered web-survey instrument. We collected lifestyle information, history of DED diagnosis, types of treatment, frequency of eye-drop usage, symptoms, and the reasons for discontinuing treatment. Statistical analyses including logistic regression were used to evaluate the risk factors of discontinuing ophthalmic follow-up for DED. A past history of clinical DED diagnosis was reported by 155 (15.0%) subjects. Of those, 130 had persistent DED, and 88 (67.7%) of the subjects reported discontinuation of ophthalmic follow-up for DED. The most prevalent reasons for ophthalmic follow-up discontinuation were time restrictions, followed by dissatisfaction with the DED treatment. Duration after DED diagnosis was the only significant risk factor for discontinuing ophthalmic follow-up after adjusting for age and sex (odds ratio = 1.09, 95% confidence interval = 1.02–1.17, p = 0.009). In conclusion, longer DED duration after diagnosis was a significant risk factor for discontinuing ophthalmic follow-up for DED. This study showed that DED ophthalmic follow-up discontinuation involves both medical and non-medical reasons. Clinicians need to be aware of them, and preventative effort is needed to avoid discontinuation. MDPI 2019-07-28 /pmc/articles/PMC6723303/ /pubmed/31357696 http://dx.doi.org/10.3390/jcm8081120 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Uchino, Miki
Yokoi, Norihiko
Kawashima, Motoko
Ryutaro, Yamanishi
Uchino, Yuichi
Tsubota, Kazuo
Treatment Trends in Dry Eye Disease and Factors Associated with Ophthalmic Follow-up Discontinuation in Japan
title Treatment Trends in Dry Eye Disease and Factors Associated with Ophthalmic Follow-up Discontinuation in Japan
title_full Treatment Trends in Dry Eye Disease and Factors Associated with Ophthalmic Follow-up Discontinuation in Japan
title_fullStr Treatment Trends in Dry Eye Disease and Factors Associated with Ophthalmic Follow-up Discontinuation in Japan
title_full_unstemmed Treatment Trends in Dry Eye Disease and Factors Associated with Ophthalmic Follow-up Discontinuation in Japan
title_short Treatment Trends in Dry Eye Disease and Factors Associated with Ophthalmic Follow-up Discontinuation in Japan
title_sort treatment trends in dry eye disease and factors associated with ophthalmic follow-up discontinuation in japan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723303/
https://www.ncbi.nlm.nih.gov/pubmed/31357696
http://dx.doi.org/10.3390/jcm8081120
work_keys_str_mv AT uchinomiki treatmenttrendsindryeyediseaseandfactorsassociatedwithophthalmicfollowupdiscontinuationinjapan
AT yokoinorihiko treatmenttrendsindryeyediseaseandfactorsassociatedwithophthalmicfollowupdiscontinuationinjapan
AT kawashimamotoko treatmenttrendsindryeyediseaseandfactorsassociatedwithophthalmicfollowupdiscontinuationinjapan
AT ryutaroyamanishi treatmenttrendsindryeyediseaseandfactorsassociatedwithophthalmicfollowupdiscontinuationinjapan
AT uchinoyuichi treatmenttrendsindryeyediseaseandfactorsassociatedwithophthalmicfollowupdiscontinuationinjapan
AT tsubotakazuo treatmenttrendsindryeyediseaseandfactorsassociatedwithophthalmicfollowupdiscontinuationinjapan