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Monte Carlo Simulations of Heat Deposition during Photothermal Skin Cancer Therapy Using Nanoparticles

Photothermal therapy using nanoparticles is a promising new approach for the treatment of cancer. The principle is to utilise plasmonic nanoparticle light interaction for efficient heat conversion. However, there are many hurdles to overcome before it can be accepted in clinical practice. One issue...

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Detalles Bibliográficos
Autores principales: Jeynes, J. Charles G., Wordingham, Freddy, Moran, Laura J., Curnow, Alison, Harries, Tim J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723333/
https://www.ncbi.nlm.nih.gov/pubmed/31387293
http://dx.doi.org/10.3390/biom9080343
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author Jeynes, J. Charles G.
Wordingham, Freddy
Moran, Laura J.
Curnow, Alison
Harries, Tim J.
author_facet Jeynes, J. Charles G.
Wordingham, Freddy
Moran, Laura J.
Curnow, Alison
Harries, Tim J.
author_sort Jeynes, J. Charles G.
collection PubMed
description Photothermal therapy using nanoparticles is a promising new approach for the treatment of cancer. The principle is to utilise plasmonic nanoparticle light interaction for efficient heat conversion. However, there are many hurdles to overcome before it can be accepted in clinical practice. One issue is a current poor characterization of the thermal dose that is distributed over the tumour region and the surrounding normal tissue. Here, we use Monte Carlo simulations of photon radiative transfer through tissue and subsequent heat diffusion calculations, to model the spatial thermal dose in a skin cancer model. We validate our heat rise simulations against experimental data from the literature and estimate the concentration of nanorods in the tumor that are associated with the heat rise. We use the cumulative equivalent minutes at 43 °C (CEM43) metric to analyse the percentage cell kill across the tumour and the surrounding normal tissue. Overall, we show that computer simulations of photothermal therapy are an invaluable tool to fully characterize thermal dose within tumour and normal tissue.
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spelling pubmed-67233332019-09-10 Monte Carlo Simulations of Heat Deposition during Photothermal Skin Cancer Therapy Using Nanoparticles Jeynes, J. Charles G. Wordingham, Freddy Moran, Laura J. Curnow, Alison Harries, Tim J. Biomolecules Article Photothermal therapy using nanoparticles is a promising new approach for the treatment of cancer. The principle is to utilise plasmonic nanoparticle light interaction for efficient heat conversion. However, there are many hurdles to overcome before it can be accepted in clinical practice. One issue is a current poor characterization of the thermal dose that is distributed over the tumour region and the surrounding normal tissue. Here, we use Monte Carlo simulations of photon radiative transfer through tissue and subsequent heat diffusion calculations, to model the spatial thermal dose in a skin cancer model. We validate our heat rise simulations against experimental data from the literature and estimate the concentration of nanorods in the tumor that are associated with the heat rise. We use the cumulative equivalent minutes at 43 °C (CEM43) metric to analyse the percentage cell kill across the tumour and the surrounding normal tissue. Overall, we show that computer simulations of photothermal therapy are an invaluable tool to fully characterize thermal dose within tumour and normal tissue. MDPI 2019-08-05 /pmc/articles/PMC6723333/ /pubmed/31387293 http://dx.doi.org/10.3390/biom9080343 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jeynes, J. Charles G.
Wordingham, Freddy
Moran, Laura J.
Curnow, Alison
Harries, Tim J.
Monte Carlo Simulations of Heat Deposition during Photothermal Skin Cancer Therapy Using Nanoparticles
title Monte Carlo Simulations of Heat Deposition during Photothermal Skin Cancer Therapy Using Nanoparticles
title_full Monte Carlo Simulations of Heat Deposition during Photothermal Skin Cancer Therapy Using Nanoparticles
title_fullStr Monte Carlo Simulations of Heat Deposition during Photothermal Skin Cancer Therapy Using Nanoparticles
title_full_unstemmed Monte Carlo Simulations of Heat Deposition during Photothermal Skin Cancer Therapy Using Nanoparticles
title_short Monte Carlo Simulations of Heat Deposition during Photothermal Skin Cancer Therapy Using Nanoparticles
title_sort monte carlo simulations of heat deposition during photothermal skin cancer therapy using nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723333/
https://www.ncbi.nlm.nih.gov/pubmed/31387293
http://dx.doi.org/10.3390/biom9080343
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