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Baru Almonds Increase the Activity of Glutathione Peroxidase in Overweight and Obese Women: A Randomized, Placebo-Controlled Trial

Background: Obesity-induced inflammation is frequently associated with higher oxidative stress. In vitro and experimental studies have considered baru almonds (Dipteryx alata Vog) as a legume seed with high antioxidant capacity. The aim of this study was to evaluate whether baru almonds are capable...

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Autores principales: de Souza, Rávila Graziany Machado, Gomes, Aline Corado, Navarro, Anderson Marliere, da Cunha, Luiz Carlos, Silva, Marina Alves Coelho, Junior, Fernando Barbosa, Mota, João Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723341/
https://www.ncbi.nlm.nih.gov/pubmed/31366053
http://dx.doi.org/10.3390/nu11081750
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author de Souza, Rávila Graziany Machado
Gomes, Aline Corado
Navarro, Anderson Marliere
da Cunha, Luiz Carlos
Silva, Marina Alves Coelho
Junior, Fernando Barbosa
Mota, João Felipe
author_facet de Souza, Rávila Graziany Machado
Gomes, Aline Corado
Navarro, Anderson Marliere
da Cunha, Luiz Carlos
Silva, Marina Alves Coelho
Junior, Fernando Barbosa
Mota, João Felipe
author_sort de Souza, Rávila Graziany Machado
collection PubMed
description Background: Obesity-induced inflammation is frequently associated with higher oxidative stress. In vitro and experimental studies have considered baru almonds (Dipteryx alata Vog) as a legume seed with high antioxidant capacity. The aim of this study was to evaluate whether baru almonds are capable of improving the inflammatory and antioxidant status in overweight and obese women. Methods: In a parallel-arm, randomized placebo-controlled trial, 46 overweight and obese women (age: 40 ± 11 years; body mass index: 33.3 ± 4.3) were randomly assigned to receive advice to follow a normocaloric and isoenergetic diet with placebo (PLA, n = 22) or similar advice plus 20 g baru almonds (BARU, n = 24) for 8 wk. Malondialdehyde (MDA), adiponectin, tumor necrosis factor-α, interleukin-6, interleukin-10, antioxidant enzymes activities (catalase—CAT; glutathione peroxidase—GPx; superoxide dismutase—SOD), and minerals were analyzed in plasma samples. Results: At baseline, groups were similar regarding the body composition, oxidative, and inflammatory parameters. The BARU group increased the activity of GPx (+0.08 U/mg, 95%CI + 0.05 to +0.12 vs. −0.07, 95%CI −0.12 to −0.03, p < 0.01) and plasma copper concentration (p = 0.037) when compared to the PLA group. No differences were observed between groups in CAT and SOD activity or MDA and cytokines concentrations. Conclusions: Baru almond supplementation increased the GPx activity in overweight and obese women.
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spelling pubmed-67233412019-09-10 Baru Almonds Increase the Activity of Glutathione Peroxidase in Overweight and Obese Women: A Randomized, Placebo-Controlled Trial de Souza, Rávila Graziany Machado Gomes, Aline Corado Navarro, Anderson Marliere da Cunha, Luiz Carlos Silva, Marina Alves Coelho Junior, Fernando Barbosa Mota, João Felipe Nutrients Article Background: Obesity-induced inflammation is frequently associated with higher oxidative stress. In vitro and experimental studies have considered baru almonds (Dipteryx alata Vog) as a legume seed with high antioxidant capacity. The aim of this study was to evaluate whether baru almonds are capable of improving the inflammatory and antioxidant status in overweight and obese women. Methods: In a parallel-arm, randomized placebo-controlled trial, 46 overweight and obese women (age: 40 ± 11 years; body mass index: 33.3 ± 4.3) were randomly assigned to receive advice to follow a normocaloric and isoenergetic diet with placebo (PLA, n = 22) or similar advice plus 20 g baru almonds (BARU, n = 24) for 8 wk. Malondialdehyde (MDA), adiponectin, tumor necrosis factor-α, interleukin-6, interleukin-10, antioxidant enzymes activities (catalase—CAT; glutathione peroxidase—GPx; superoxide dismutase—SOD), and minerals were analyzed in plasma samples. Results: At baseline, groups were similar regarding the body composition, oxidative, and inflammatory parameters. The BARU group increased the activity of GPx (+0.08 U/mg, 95%CI + 0.05 to +0.12 vs. −0.07, 95%CI −0.12 to −0.03, p < 0.01) and plasma copper concentration (p = 0.037) when compared to the PLA group. No differences were observed between groups in CAT and SOD activity or MDA and cytokines concentrations. Conclusions: Baru almond supplementation increased the GPx activity in overweight and obese women. MDPI 2019-07-30 /pmc/articles/PMC6723341/ /pubmed/31366053 http://dx.doi.org/10.3390/nu11081750 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Souza, Rávila Graziany Machado
Gomes, Aline Corado
Navarro, Anderson Marliere
da Cunha, Luiz Carlos
Silva, Marina Alves Coelho
Junior, Fernando Barbosa
Mota, João Felipe
Baru Almonds Increase the Activity of Glutathione Peroxidase in Overweight and Obese Women: A Randomized, Placebo-Controlled Trial
title Baru Almonds Increase the Activity of Glutathione Peroxidase in Overweight and Obese Women: A Randomized, Placebo-Controlled Trial
title_full Baru Almonds Increase the Activity of Glutathione Peroxidase in Overweight and Obese Women: A Randomized, Placebo-Controlled Trial
title_fullStr Baru Almonds Increase the Activity of Glutathione Peroxidase in Overweight and Obese Women: A Randomized, Placebo-Controlled Trial
title_full_unstemmed Baru Almonds Increase the Activity of Glutathione Peroxidase in Overweight and Obese Women: A Randomized, Placebo-Controlled Trial
title_short Baru Almonds Increase the Activity of Glutathione Peroxidase in Overweight and Obese Women: A Randomized, Placebo-Controlled Trial
title_sort baru almonds increase the activity of glutathione peroxidase in overweight and obese women: a randomized, placebo-controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723341/
https://www.ncbi.nlm.nih.gov/pubmed/31366053
http://dx.doi.org/10.3390/nu11081750
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