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Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study

Identification of modifiable risk factors for breast cancer is critical for primary prevention of the disease. The aim of this study was to evaluate how certain lifestyle variables modify the chances of developing breast cancer based on menopausal status. A case-control study was performed in a grou...

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Autores principales: Godinho-Mota, Jordana Carolina Marques, Gonçalves, Larissa Vaz, Mota, Joao Felipe, Soares, Leonardo Ribeiro, Schincaglia, Raquel Machado, Martins, Karine Anusca, Freitas-Junior, Ruffo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723386/
https://www.ncbi.nlm.nih.gov/pubmed/31408930
http://dx.doi.org/10.3390/nu11081871
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author Godinho-Mota, Jordana Carolina Marques
Gonçalves, Larissa Vaz
Mota, Joao Felipe
Soares, Leonardo Ribeiro
Schincaglia, Raquel Machado
Martins, Karine Anusca
Freitas-Junior, Ruffo
author_facet Godinho-Mota, Jordana Carolina Marques
Gonçalves, Larissa Vaz
Mota, Joao Felipe
Soares, Leonardo Ribeiro
Schincaglia, Raquel Machado
Martins, Karine Anusca
Freitas-Junior, Ruffo
author_sort Godinho-Mota, Jordana Carolina Marques
collection PubMed
description Identification of modifiable risk factors for breast cancer is critical for primary prevention of the disease. The aim of this study was to evaluate how certain lifestyle variables modify the chances of developing breast cancer based on menopausal status. A case-control study was performed in a group of 542 women, 197 who were diagnosed with breast cancer and 344 control individuals. The groups were matched by age, body mass index, and menopausal status. Participants were evaluated for level of physical activity, alcohol consumption, smoking habit, weight, height, and waist circumference (WC). A multivariate logistic regression model was used to estimate odds ratios and 95% confidence intervals (95% CI). Regular consumption of alcoholic beverages (2.91, 95% CI 1.58–5.38 and 1.86, 95% CI 1.15–3.03) and sedentary behavior (2.08; 95% CI 1.12–3.85 and 1.81; 95% CI 1.12–2.94) were associated with breast cancer risk in pre- and postmenopausal women, respectively. High WC (3.31, 95% CI 1.45–7.55) was associated with an increased risk of developing breast cancer in premenopausal women. While in postmenopausal women, current smoking (2.43, 95% CI 1.01–5.83) or previous history of smoking (1.90; 95% CI 1.14–3.14) increased the chances of developing breast cancer. Sedentary behavior and current consumption of alcoholic beverages were more likely to increase the risk of developing breast cancer regardless of menopausal status.
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spelling pubmed-67233862019-09-10 Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study Godinho-Mota, Jordana Carolina Marques Gonçalves, Larissa Vaz Mota, Joao Felipe Soares, Leonardo Ribeiro Schincaglia, Raquel Machado Martins, Karine Anusca Freitas-Junior, Ruffo Nutrients Article Identification of modifiable risk factors for breast cancer is critical for primary prevention of the disease. The aim of this study was to evaluate how certain lifestyle variables modify the chances of developing breast cancer based on menopausal status. A case-control study was performed in a group of 542 women, 197 who were diagnosed with breast cancer and 344 control individuals. The groups were matched by age, body mass index, and menopausal status. Participants were evaluated for level of physical activity, alcohol consumption, smoking habit, weight, height, and waist circumference (WC). A multivariate logistic regression model was used to estimate odds ratios and 95% confidence intervals (95% CI). Regular consumption of alcoholic beverages (2.91, 95% CI 1.58–5.38 and 1.86, 95% CI 1.15–3.03) and sedentary behavior (2.08; 95% CI 1.12–3.85 and 1.81; 95% CI 1.12–2.94) were associated with breast cancer risk in pre- and postmenopausal women, respectively. High WC (3.31, 95% CI 1.45–7.55) was associated with an increased risk of developing breast cancer in premenopausal women. While in postmenopausal women, current smoking (2.43, 95% CI 1.01–5.83) or previous history of smoking (1.90; 95% CI 1.14–3.14) increased the chances of developing breast cancer. Sedentary behavior and current consumption of alcoholic beverages were more likely to increase the risk of developing breast cancer regardless of menopausal status. MDPI 2019-08-12 /pmc/articles/PMC6723386/ /pubmed/31408930 http://dx.doi.org/10.3390/nu11081871 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Godinho-Mota, Jordana Carolina Marques
Gonçalves, Larissa Vaz
Mota, Joao Felipe
Soares, Leonardo Ribeiro
Schincaglia, Raquel Machado
Martins, Karine Anusca
Freitas-Junior, Ruffo
Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study
title Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study
title_full Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study
title_fullStr Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study
title_full_unstemmed Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study
title_short Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study
title_sort sedentary behavior and alcohol consumption increase breast cancer risk regardless of menopausal status: a case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723386/
https://www.ncbi.nlm.nih.gov/pubmed/31408930
http://dx.doi.org/10.3390/nu11081871
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