Secondary Metabolites with α-Glucosidase Inhibitory Activity from the Mangrove Fungus Mycosphaerella sp. SYSU-DZG01

Four new metabolites, asperchalasine I (1), dibefurin B (2) and two epicoccine derivatives (3 and 4), together with seven known compounds (5–11) were isolated from a mangrove fungus Mycosphaerella sp. SYSU-DZG01. The structures of compounds 1–4 were established from extensive spectroscopic data and...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiu, Pei, Liu, Zhaoming, Chen, Yan, Cai, Runlin, Chen, Guangying, She, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723402/
https://www.ncbi.nlm.nih.gov/pubmed/31434338
http://dx.doi.org/10.3390/md17080483
_version_ 1783448759661756416
author Qiu, Pei
Liu, Zhaoming
Chen, Yan
Cai, Runlin
Chen, Guangying
She, Zhigang
author_facet Qiu, Pei
Liu, Zhaoming
Chen, Yan
Cai, Runlin
Chen, Guangying
She, Zhigang
author_sort Qiu, Pei
collection PubMed
description Four new metabolites, asperchalasine I (1), dibefurin B (2) and two epicoccine derivatives (3 and 4), together with seven known compounds (5–11) were isolated from a mangrove fungus Mycosphaerella sp. SYSU-DZG01. The structures of compounds 1–4 were established from extensive spectroscopic data and HRESIMS analysis. The absolute configuration of 1 was deduced by comparison of ECD data with that of a known structure. The stereostructures of 2–4 were further confirmed by single-crystal X-ray diffraction. Compounds 1, 8 and 9 exhibited significant α-glucosidase inhibitory activity with IC(50) values of 17.1, 26.7 and 15.7 μM, respectively. Compounds 1, 4, 6 and 8 showed antioxidant activity by scavenging DPPH· with EC(50) values ranging from 16.3 to 85.8 μM.
format Online
Article
Text
id pubmed-6723402
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67234022019-09-10 Secondary Metabolites with α-Glucosidase Inhibitory Activity from the Mangrove Fungus Mycosphaerella sp. SYSU-DZG01 Qiu, Pei Liu, Zhaoming Chen, Yan Cai, Runlin Chen, Guangying She, Zhigang Mar Drugs Article Four new metabolites, asperchalasine I (1), dibefurin B (2) and two epicoccine derivatives (3 and 4), together with seven known compounds (5–11) were isolated from a mangrove fungus Mycosphaerella sp. SYSU-DZG01. The structures of compounds 1–4 were established from extensive spectroscopic data and HRESIMS analysis. The absolute configuration of 1 was deduced by comparison of ECD data with that of a known structure. The stereostructures of 2–4 were further confirmed by single-crystal X-ray diffraction. Compounds 1, 8 and 9 exhibited significant α-glucosidase inhibitory activity with IC(50) values of 17.1, 26.7 and 15.7 μM, respectively. Compounds 1, 4, 6 and 8 showed antioxidant activity by scavenging DPPH· with EC(50) values ranging from 16.3 to 85.8 μM. MDPI 2019-08-20 /pmc/articles/PMC6723402/ /pubmed/31434338 http://dx.doi.org/10.3390/md17080483 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Qiu, Pei
Liu, Zhaoming
Chen, Yan
Cai, Runlin
Chen, Guangying
She, Zhigang
Secondary Metabolites with α-Glucosidase Inhibitory Activity from the Mangrove Fungus Mycosphaerella sp. SYSU-DZG01
title Secondary Metabolites with α-Glucosidase Inhibitory Activity from the Mangrove Fungus Mycosphaerella sp. SYSU-DZG01
title_full Secondary Metabolites with α-Glucosidase Inhibitory Activity from the Mangrove Fungus Mycosphaerella sp. SYSU-DZG01
title_fullStr Secondary Metabolites with α-Glucosidase Inhibitory Activity from the Mangrove Fungus Mycosphaerella sp. SYSU-DZG01
title_full_unstemmed Secondary Metabolites with α-Glucosidase Inhibitory Activity from the Mangrove Fungus Mycosphaerella sp. SYSU-DZG01
title_short Secondary Metabolites with α-Glucosidase Inhibitory Activity from the Mangrove Fungus Mycosphaerella sp. SYSU-DZG01
title_sort secondary metabolites with α-glucosidase inhibitory activity from the mangrove fungus mycosphaerella sp. sysu-dzg01
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723402/
https://www.ncbi.nlm.nih.gov/pubmed/31434338
http://dx.doi.org/10.3390/md17080483
work_keys_str_mv AT qiupei secondarymetaboliteswithaglucosidaseinhibitoryactivityfromthemangrovefungusmycosphaerellaspsysudzg01
AT liuzhaoming secondarymetaboliteswithaglucosidaseinhibitoryactivityfromthemangrovefungusmycosphaerellaspsysudzg01
AT chenyan secondarymetaboliteswithaglucosidaseinhibitoryactivityfromthemangrovefungusmycosphaerellaspsysudzg01
AT cairunlin secondarymetaboliteswithaglucosidaseinhibitoryactivityfromthemangrovefungusmycosphaerellaspsysudzg01
AT chenguangying secondarymetaboliteswithaglucosidaseinhibitoryactivityfromthemangrovefungusmycosphaerellaspsysudzg01
AT shezhigang secondarymetaboliteswithaglucosidaseinhibitoryactivityfromthemangrovefungusmycosphaerellaspsysudzg01

Ejemplares similares