Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide

Autosomal dominantly inherited genetic disorders such as corneal dystrophies are amenable to allele-specific gene silencing with small interfering RNA (siRNA). siRNA delivered to the cornea by injection, although effective, is not suitable for a frequent long-term treatment regimen, whereas topical...

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Detalles Bibliográficos
Autores principales: Schiroli, Davide, Gómara, María J., Maurizi, Eleonora, Atkinson, Sarah D., Mairs, Laura, Christie, Kathleen A., Cobice, Diego F., McCrudden, Cian M., Nesbit, M. Andrew, Haro, Isabel, Moore, Tara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723413/
https://www.ncbi.nlm.nih.gov/pubmed/31476668
http://dx.doi.org/10.1016/j.omtn.2019.07.017

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