Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD

The biological effects of insulin signaling are regulated by the phosphorylation of insulin receptor substrate 1 (IRS1) at serine (Ser) residues. In the brain, phosphorylation of IRS1 at specific Ser sites increases in patients with Alzheimer’s disease (AD) and its animal models. However, whether th...

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Detalles Bibliográficos
Autores principales: Wang, Wei, Tanokashira, Daisuke, Fukui, Yusuke, Maruyama, Megumi, Kuroiwa, Chiemi, Saito, Takashi, Saido, Takaomi C., Taguchi, Akiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723493/
https://www.ncbi.nlm.nih.gov/pubmed/31426549
http://dx.doi.org/10.3390/nu11081942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723493/
https://www.ncbi.nlm.nih.gov/pubmed/31426549
http://dx.doi.org/10.3390/nu11081942

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