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New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities

Seven new unusual polysulfated steroids—topsentiasterol sulfate G (1), topsentiasterol sulfate I (2), topsentiasterol sulfate H (3), bromotopsentiasterol sulfate D (4), dichlorotopsentiasterol sulfate D (8), bromochlorotopsentiasterol sulfate D (9), and 4β-hydroxyhalistanol sulfate C (10), as well a...

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Autores principales: Tabakmakher, Kseniya M., Makarieva, Tatyana N., Denisenko, Vladimir A., Popov, Roman S., Dmitrenok, Pavel S., Dyshlovoy, Sergey A., Grebnev, Boris B., Bokemeyer, Carsten, von Amsberg, Gunhild, Cuong, Nguyen X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723502/
https://www.ncbi.nlm.nih.gov/pubmed/31357591
http://dx.doi.org/10.3390/md17080445
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author Tabakmakher, Kseniya M.
Makarieva, Tatyana N.
Denisenko, Vladimir A.
Popov, Roman S.
Dmitrenok, Pavel S.
Dyshlovoy, Sergey A.
Grebnev, Boris B.
Bokemeyer, Carsten
von Amsberg, Gunhild
Cuong, Nguyen X.
author_facet Tabakmakher, Kseniya M.
Makarieva, Tatyana N.
Denisenko, Vladimir A.
Popov, Roman S.
Dmitrenok, Pavel S.
Dyshlovoy, Sergey A.
Grebnev, Boris B.
Bokemeyer, Carsten
von Amsberg, Gunhild
Cuong, Nguyen X.
author_sort Tabakmakher, Kseniya M.
collection PubMed
description Seven new unusual polysulfated steroids—topsentiasterol sulfate G (1), topsentiasterol sulfate I (2), topsentiasterol sulfate H (3), bromotopsentiasterol sulfate D (4), dichlorotopsentiasterol sulfate D (8), bromochlorotopsentiasterol sulfate D (9), and 4β-hydroxyhalistanol sulfate C (10), as well as three previously described—topsentiasterol sulfate D (7), chlorotopsentiasterol sulfate D (5) and iodotopsentiasterol sulfate D (6) have been isolated from the marine sponge Halichondria vansoesti. Structures of these compounds were determined by detailed analysis of 1D- and 2D-NMR and HRESIMS data, as well as chemical transformations. The effects of the compounds on human prostate cancer cells PC-3 and 22Rv1 were investigated.
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spelling pubmed-67235022019-09-10 New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities Tabakmakher, Kseniya M. Makarieva, Tatyana N. Denisenko, Vladimir A. Popov, Roman S. Dmitrenok, Pavel S. Dyshlovoy, Sergey A. Grebnev, Boris B. Bokemeyer, Carsten von Amsberg, Gunhild Cuong, Nguyen X. Mar Drugs Article Seven new unusual polysulfated steroids—topsentiasterol sulfate G (1), topsentiasterol sulfate I (2), topsentiasterol sulfate H (3), bromotopsentiasterol sulfate D (4), dichlorotopsentiasterol sulfate D (8), bromochlorotopsentiasterol sulfate D (9), and 4β-hydroxyhalistanol sulfate C (10), as well as three previously described—topsentiasterol sulfate D (7), chlorotopsentiasterol sulfate D (5) and iodotopsentiasterol sulfate D (6) have been isolated from the marine sponge Halichondria vansoesti. Structures of these compounds were determined by detailed analysis of 1D- and 2D-NMR and HRESIMS data, as well as chemical transformations. The effects of the compounds on human prostate cancer cells PC-3 and 22Rv1 were investigated. MDPI 2019-07-27 /pmc/articles/PMC6723502/ /pubmed/31357591 http://dx.doi.org/10.3390/md17080445 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tabakmakher, Kseniya M.
Makarieva, Tatyana N.
Denisenko, Vladimir A.
Popov, Roman S.
Dmitrenok, Pavel S.
Dyshlovoy, Sergey A.
Grebnev, Boris B.
Bokemeyer, Carsten
von Amsberg, Gunhild
Cuong, Nguyen X.
New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities
title New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities
title_full New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities
title_fullStr New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities
title_full_unstemmed New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities
title_short New Trisulfated Steroids from the Vietnamese Marine Sponge Halichondria vansoesti and Their PSA Expression and Glucose Uptake Inhibitory Activities
title_sort new trisulfated steroids from the vietnamese marine sponge halichondria vansoesti and their psa expression and glucose uptake inhibitory activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723502/
https://www.ncbi.nlm.nih.gov/pubmed/31357591
http://dx.doi.org/10.3390/md17080445
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