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Body Mass Index Z-Score Modifies the Association between Added Sugar Intake and Arterial Stiffness in Youth with Type 1 Diabetes: The Search Nutrition Ancillary Study
The relationship between added sugar and arterial stiffness in youth with type 1 diabetes (T1D) has not been well-described. We used data from the SEARCH for Diabetes in Youth Study (SEARCH), an ongoing observational cohort study, to determine the association between added sugar and arterial stiffne...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723563/ https://www.ncbi.nlm.nih.gov/pubmed/31366063 http://dx.doi.org/10.3390/nu11081752 |
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author | The, Natalie S. Couch, Sarah C. Urbina, Elaine M. Crandell, Jamie L. Liese, Angela D. Dabelea, Dana Kim, Grace J. Tooze, Janet A. Lawrence, Jean M. Mayer-Davis, Elizabeth J. |
author_facet | The, Natalie S. Couch, Sarah C. Urbina, Elaine M. Crandell, Jamie L. Liese, Angela D. Dabelea, Dana Kim, Grace J. Tooze, Janet A. Lawrence, Jean M. Mayer-Davis, Elizabeth J. |
author_sort | The, Natalie S. |
collection | PubMed |
description | The relationship between added sugar and arterial stiffness in youth with type 1 diabetes (T1D) has not been well-described. We used data from the SEARCH for Diabetes in Youth Study (SEARCH), an ongoing observational cohort study, to determine the association between added sugar and arterial stiffness in individuals diagnosed with T1D <20 years of age (n = 1539; mean diabetes duration of 7.9 ± 1.9 years). Added sugar intake was assessed by a food frequency questionnaire, and arterial stiffness measures included pulse wave velocity (PWV) and augmentation index. Separate multivariate linear regression models were used to evaluate the association between added sugar and arterial stiffness. Separate interaction terms were included to test for effect modification by body mass index (BMI) z-score and physical activity (PA). Overall, there was no association between added sugar and arterial stiffness (P > 0.05); however, the association between added sugar and arterial stiffness differed by BMI z-score (P for interaction = 0.003). For participants with lower BMI z-scores, added sugar intake was positively associated with PWV trunk measurements, whereas there was no association for those who had a higher BMI z-score. PA did not significantly modify the association between added sugar and arterial stiffness. Further research is needed to determine the longitudinal relationship and to confirm that obesity differentially affects this association. |
format | Online Article Text |
id | pubmed-6723563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67235632019-09-10 Body Mass Index Z-Score Modifies the Association between Added Sugar Intake and Arterial Stiffness in Youth with Type 1 Diabetes: The Search Nutrition Ancillary Study The, Natalie S. Couch, Sarah C. Urbina, Elaine M. Crandell, Jamie L. Liese, Angela D. Dabelea, Dana Kim, Grace J. Tooze, Janet A. Lawrence, Jean M. Mayer-Davis, Elizabeth J. Nutrients Article The relationship between added sugar and arterial stiffness in youth with type 1 diabetes (T1D) has not been well-described. We used data from the SEARCH for Diabetes in Youth Study (SEARCH), an ongoing observational cohort study, to determine the association between added sugar and arterial stiffness in individuals diagnosed with T1D <20 years of age (n = 1539; mean diabetes duration of 7.9 ± 1.9 years). Added sugar intake was assessed by a food frequency questionnaire, and arterial stiffness measures included pulse wave velocity (PWV) and augmentation index. Separate multivariate linear regression models were used to evaluate the association between added sugar and arterial stiffness. Separate interaction terms were included to test for effect modification by body mass index (BMI) z-score and physical activity (PA). Overall, there was no association between added sugar and arterial stiffness (P > 0.05); however, the association between added sugar and arterial stiffness differed by BMI z-score (P for interaction = 0.003). For participants with lower BMI z-scores, added sugar intake was positively associated with PWV trunk measurements, whereas there was no association for those who had a higher BMI z-score. PA did not significantly modify the association between added sugar and arterial stiffness. Further research is needed to determine the longitudinal relationship and to confirm that obesity differentially affects this association. MDPI 2019-07-30 /pmc/articles/PMC6723563/ /pubmed/31366063 http://dx.doi.org/10.3390/nu11081752 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article The, Natalie S. Couch, Sarah C. Urbina, Elaine M. Crandell, Jamie L. Liese, Angela D. Dabelea, Dana Kim, Grace J. Tooze, Janet A. Lawrence, Jean M. Mayer-Davis, Elizabeth J. Body Mass Index Z-Score Modifies the Association between Added Sugar Intake and Arterial Stiffness in Youth with Type 1 Diabetes: The Search Nutrition Ancillary Study |
title | Body Mass Index Z-Score Modifies the Association between Added Sugar Intake and Arterial Stiffness in Youth with Type 1 Diabetes: The Search Nutrition Ancillary Study |
title_full | Body Mass Index Z-Score Modifies the Association between Added Sugar Intake and Arterial Stiffness in Youth with Type 1 Diabetes: The Search Nutrition Ancillary Study |
title_fullStr | Body Mass Index Z-Score Modifies the Association between Added Sugar Intake and Arterial Stiffness in Youth with Type 1 Diabetes: The Search Nutrition Ancillary Study |
title_full_unstemmed | Body Mass Index Z-Score Modifies the Association between Added Sugar Intake and Arterial Stiffness in Youth with Type 1 Diabetes: The Search Nutrition Ancillary Study |
title_short | Body Mass Index Z-Score Modifies the Association between Added Sugar Intake and Arterial Stiffness in Youth with Type 1 Diabetes: The Search Nutrition Ancillary Study |
title_sort | body mass index z-score modifies the association between added sugar intake and arterial stiffness in youth with type 1 diabetes: the search nutrition ancillary study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723563/ https://www.ncbi.nlm.nih.gov/pubmed/31366063 http://dx.doi.org/10.3390/nu11081752 |
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