Cargando…
Association of Long-Term Treatment by Botulinum Neurotoxins and Occupational Therapy with Subjective Physical Status in Patients with Post-Stroke Hemiplegia
The short-term effects of botulinum toxin type A (BoNT-A) treatment in stroke patients with upper extremity are well established. This study examined the association between the recovery of motor function of the upper extremity with subjective physical symptoms in outpatients receiving long-term BoN...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723584/ https://www.ncbi.nlm.nih.gov/pubmed/31382438 http://dx.doi.org/10.3390/toxins11080453 |
_version_ | 1783448803440852992 |
---|---|
author | Hamaguchi, Toyohiro Abo, Masahiro Murata, Kai Kenmoku, Mari Yoshizawa, Izumi Ishikawa, Atsushi Suzuki, Makoto Nakaya, Naoki Taguchi, Kensuke |
author_facet | Hamaguchi, Toyohiro Abo, Masahiro Murata, Kai Kenmoku, Mari Yoshizawa, Izumi Ishikawa, Atsushi Suzuki, Makoto Nakaya, Naoki Taguchi, Kensuke |
author_sort | Hamaguchi, Toyohiro |
collection | PubMed |
description | The short-term effects of botulinum toxin type A (BoNT-A) treatment in stroke patients with upper extremity are well established. This study examined the association between the recovery of motor function of the upper extremity with subjective physical symptoms in outpatients receiving long-term BoNT-A and occupational therapy following stroke. We also investigated the expectations of patients who elected to continue treatment. Forty-seven patients (23 men and 24 women) aged 61 years received BoNT-A treatment more than 20 times. The subjective physical status was analyzed by using the visual analogue scale score through an eight-item questionnaire. Recovery of motor function in the upper extremity was detected by calculating the change (delta) in Fugl–Mayer Assessment (FMA), and ordinal logistic modeling analysis was used to determine the association between the delta-FMA score and the subjective level of agreement for each item. When the ordinal logistic modeling fit was statistically significant, results were interpreted as having logistic probability. The logistic curves discriminating one point (strongly disagree) from five points (strongly agree) were fit in a stepwise fashion. This study suggests that patients receiving long-term BoNT-A treatment and occupational therapy experienced an increased upper extremity mitigation and decreased insomnia after injection, regardless of the recovery of motor function. |
format | Online Article Text |
id | pubmed-6723584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67235842019-09-10 Association of Long-Term Treatment by Botulinum Neurotoxins and Occupational Therapy with Subjective Physical Status in Patients with Post-Stroke Hemiplegia Hamaguchi, Toyohiro Abo, Masahiro Murata, Kai Kenmoku, Mari Yoshizawa, Izumi Ishikawa, Atsushi Suzuki, Makoto Nakaya, Naoki Taguchi, Kensuke Toxins (Basel) Article The short-term effects of botulinum toxin type A (BoNT-A) treatment in stroke patients with upper extremity are well established. This study examined the association between the recovery of motor function of the upper extremity with subjective physical symptoms in outpatients receiving long-term BoNT-A and occupational therapy following stroke. We also investigated the expectations of patients who elected to continue treatment. Forty-seven patients (23 men and 24 women) aged 61 years received BoNT-A treatment more than 20 times. The subjective physical status was analyzed by using the visual analogue scale score through an eight-item questionnaire. Recovery of motor function in the upper extremity was detected by calculating the change (delta) in Fugl–Mayer Assessment (FMA), and ordinal logistic modeling analysis was used to determine the association between the delta-FMA score and the subjective level of agreement for each item. When the ordinal logistic modeling fit was statistically significant, results were interpreted as having logistic probability. The logistic curves discriminating one point (strongly disagree) from five points (strongly agree) were fit in a stepwise fashion. This study suggests that patients receiving long-term BoNT-A treatment and occupational therapy experienced an increased upper extremity mitigation and decreased insomnia after injection, regardless of the recovery of motor function. MDPI 2019-08-02 /pmc/articles/PMC6723584/ /pubmed/31382438 http://dx.doi.org/10.3390/toxins11080453 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hamaguchi, Toyohiro Abo, Masahiro Murata, Kai Kenmoku, Mari Yoshizawa, Izumi Ishikawa, Atsushi Suzuki, Makoto Nakaya, Naoki Taguchi, Kensuke Association of Long-Term Treatment by Botulinum Neurotoxins and Occupational Therapy with Subjective Physical Status in Patients with Post-Stroke Hemiplegia |
title | Association of Long-Term Treatment by Botulinum Neurotoxins and Occupational Therapy with Subjective Physical Status in Patients with Post-Stroke Hemiplegia |
title_full | Association of Long-Term Treatment by Botulinum Neurotoxins and Occupational Therapy with Subjective Physical Status in Patients with Post-Stroke Hemiplegia |
title_fullStr | Association of Long-Term Treatment by Botulinum Neurotoxins and Occupational Therapy with Subjective Physical Status in Patients with Post-Stroke Hemiplegia |
title_full_unstemmed | Association of Long-Term Treatment by Botulinum Neurotoxins and Occupational Therapy with Subjective Physical Status in Patients with Post-Stroke Hemiplegia |
title_short | Association of Long-Term Treatment by Botulinum Neurotoxins and Occupational Therapy with Subjective Physical Status in Patients with Post-Stroke Hemiplegia |
title_sort | association of long-term treatment by botulinum neurotoxins and occupational therapy with subjective physical status in patients with post-stroke hemiplegia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723584/ https://www.ncbi.nlm.nih.gov/pubmed/31382438 http://dx.doi.org/10.3390/toxins11080453 |
work_keys_str_mv | AT hamaguchitoyohiro associationoflongtermtreatmentbybotulinumneurotoxinsandoccupationaltherapywithsubjectivephysicalstatusinpatientswithpoststrokehemiplegia AT abomasahiro associationoflongtermtreatmentbybotulinumneurotoxinsandoccupationaltherapywithsubjectivephysicalstatusinpatientswithpoststrokehemiplegia AT muratakai associationoflongtermtreatmentbybotulinumneurotoxinsandoccupationaltherapywithsubjectivephysicalstatusinpatientswithpoststrokehemiplegia AT kenmokumari associationoflongtermtreatmentbybotulinumneurotoxinsandoccupationaltherapywithsubjectivephysicalstatusinpatientswithpoststrokehemiplegia AT yoshizawaizumi associationoflongtermtreatmentbybotulinumneurotoxinsandoccupationaltherapywithsubjectivephysicalstatusinpatientswithpoststrokehemiplegia AT ishikawaatsushi associationoflongtermtreatmentbybotulinumneurotoxinsandoccupationaltherapywithsubjectivephysicalstatusinpatientswithpoststrokehemiplegia AT suzukimakoto associationoflongtermtreatmentbybotulinumneurotoxinsandoccupationaltherapywithsubjectivephysicalstatusinpatientswithpoststrokehemiplegia AT nakayanaoki associationoflongtermtreatmentbybotulinumneurotoxinsandoccupationaltherapywithsubjectivephysicalstatusinpatientswithpoststrokehemiplegia AT taguchikensuke associationoflongtermtreatmentbybotulinumneurotoxinsandoccupationaltherapywithsubjectivephysicalstatusinpatientswithpoststrokehemiplegia |