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DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion

Type II topoisomerases regulate DNA topology by making a double-stranded break in one DNA duplex, transporting another DNA segment through this break and then resealing it. Bacterial type IIA topoisomerase inhibitors, such as fluoroquinolones and novel bacterial topoisomerase inhibitors, can trap DN...

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Detalles Bibliográficos
Autores principales:	Bax, Benjamin D., Murshudov, Garib, Maxwell, Anthony, Germe, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723622/ https://www.ncbi.nlm.nih.gov/pubmed/31301408 http://dx.doi.org/10.1016/j.jmb.2019.07.008

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