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Gangliosides: The Double-Edge Sword of Neuro-Ectodermal Derived Tumors
Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are mostly localized at the plasma membrane in lipid raft domains and implicated in many cellular signaling pathways mostly by interacting with tyrosine kinase receptors. Gangliosides are divided into four series acco...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723632/ https://www.ncbi.nlm.nih.gov/pubmed/31357634 http://dx.doi.org/10.3390/biom9080311 |
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author | Cavdarli, Sumeyye Groux-Degroote, Sophie Delannoy, Philippe |
author_facet | Cavdarli, Sumeyye Groux-Degroote, Sophie Delannoy, Philippe |
author_sort | Cavdarli, Sumeyye |
collection | PubMed |
description | Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are mostly localized at the plasma membrane in lipid raft domains and implicated in many cellular signaling pathways mostly by interacting with tyrosine kinase receptors. Gangliosides are divided into four series according to the number of sialic acid residues, which can be also modified by O-acetylation. Both ganglioside expression and sialic acid modifications can be modified in pathological conditions such as cancer, which can induce either pro-cancerous or anti-cancerous effects. In this review, we summarize the specific functions of gangliosides in neuro-ectodermal derived tumors, and their roles in reprogramming the lipidomic profile of cell membrane occurring with the induction of epithelial-mesenchymal transition. |
format | Online Article Text |
id | pubmed-6723632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67236322019-09-10 Gangliosides: The Double-Edge Sword of Neuro-Ectodermal Derived Tumors Cavdarli, Sumeyye Groux-Degroote, Sophie Delannoy, Philippe Biomolecules Review Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are mostly localized at the plasma membrane in lipid raft domains and implicated in many cellular signaling pathways mostly by interacting with tyrosine kinase receptors. Gangliosides are divided into four series according to the number of sialic acid residues, which can be also modified by O-acetylation. Both ganglioside expression and sialic acid modifications can be modified in pathological conditions such as cancer, which can induce either pro-cancerous or anti-cancerous effects. In this review, we summarize the specific functions of gangliosides in neuro-ectodermal derived tumors, and their roles in reprogramming the lipidomic profile of cell membrane occurring with the induction of epithelial-mesenchymal transition. MDPI 2019-07-27 /pmc/articles/PMC6723632/ /pubmed/31357634 http://dx.doi.org/10.3390/biom9080311 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cavdarli, Sumeyye Groux-Degroote, Sophie Delannoy, Philippe Gangliosides: The Double-Edge Sword of Neuro-Ectodermal Derived Tumors |
title | Gangliosides: The Double-Edge Sword of Neuro-Ectodermal Derived Tumors |
title_full | Gangliosides: The Double-Edge Sword of Neuro-Ectodermal Derived Tumors |
title_fullStr | Gangliosides: The Double-Edge Sword of Neuro-Ectodermal Derived Tumors |
title_full_unstemmed | Gangliosides: The Double-Edge Sword of Neuro-Ectodermal Derived Tumors |
title_short | Gangliosides: The Double-Edge Sword of Neuro-Ectodermal Derived Tumors |
title_sort | gangliosides: the double-edge sword of neuro-ectodermal derived tumors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723632/ https://www.ncbi.nlm.nih.gov/pubmed/31357634 http://dx.doi.org/10.3390/biom9080311 |
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