Cargando…

Antibody Therapies for Acute Myeloid Leukemia: Unconjugated, Toxin-Conjugated, Radio-Conjugated and Multivalent Formats

In recent decades, therapy for acute myeloid leukemia (AML) has remained relatively unchanged, with chemotherapy regimens primarily consisting of an induction regimen based on a daunorubicin and cytarabine backbone, followed by consolidation chemotherapy. Patients who are relapsed or refractory can...

Descripción completa

Detalles Bibliográficos
Autores principales:	Williams, Brent A., Law, Arjun, Hunyadkurti, Judit, Desilets, Stephanie, Leyton, Jeffrey V., Keating, Armand
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723634/ https://www.ncbi.nlm.nih.gov/pubmed/31434267 http://dx.doi.org/10.3390/jcm8081261

Ejemplares similares

In Vitro Antibacterial Activity of Unconjugated and Conjugated Bile Salts on Staphylococcus aureus
por: Sannasiddappa, Thippeswamy H., et al.
Publicado: (2017)

Design and synthesis of multivalent neoglycoconjugates by click conjugations
por: Ding, Feiqing, et al.
Publicado: (2014)

Multivalent glycocyclopeptides: conjugation methods and biological applications
por: Goyard, David, et al.
Publicado: (2022)

Circulating Conjugated and Unconjugated Vitamin D Metabolite Measurements by Liquid Chromatography Mass Spectrometry
por: Jenkinson, Carl, et al.
Publicado: (2021)

Assessment of the Drug Interaction Potential of Unconjugated and GalNAc(3)-Conjugated 2′-MOE-ASOs
por: Shemesh, Colby S., et al.
Publicado: (2017)

Multivalent Polymers for Drug Delivery and Imaging: The Challenges of Conjugation
por: van Dongen, Mallory A., et al.
Publicado: (2014)

Multivalent Peptide–Nanoparticle Conjugates for Influenza‐Virus Inhibition
por: Lauster, Daniel, et al.
Publicado: (2017)

Multivalent γ‐PGA‐Exendin‐4 Conjugates to Target Pancreatic β‐Cells
por: Rossi, Lorenzo, et al.
Publicado: (2022)

Study on the Heterogeneity of T-DM1 and the Analysis of the Unconjugated Linker Structure under a Stable Conjugation Process
por: Wu, Guanghao, et al.
Publicado: (2019)

Alternate layer by layered self assembly of conjugated and unconjugated Salen based nanowires as capacitive pseudo supercapacitor
por: Doroodmand, Mohammad Mahdi, et al.
Publicado: (2021)

Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults
por: Ravichandran, Sathyabaarathi, et al.
Publicado: (2023)

Dextramabs: A Novel Format of Antibody‐Drug Conjugates Featuring a Multivalent Polysaccharide Scaffold
por: Schneider, Hendrik, et al.
Publicado: (2019)

Synthesis of multivalent polymer–aptamer conjugates with enhanced inhibitory potency
por: Martin, Jacob T, et al.
Publicado: (2018)

Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate
por: Puthenveetil, Sujiet, et al.
Publicado: (2017)

Solid-Phase Synthesis of Self-Assembling Multivalent π-Conjugated Peptides
por: Sanders, Allix M., et al.
Publicado: (2017)

Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes
por: Tanowitz, Michael, et al.
Publicado: (2017)

Enhanced A(3 )adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates
por: Klutz, Athena M, et al.
Publicado: (2008)

Multivalent Conjugation of Antibody to Dendrimers for the Enhanced Capture and Regulation on Colon Cancer Cells
por: Xie, Jingjing, et al.
Publicado: (2015)

Polyoxazoline multivalently conjugated with indocyanine green for sensitive in vivo photoacoustic imaging of tumors
por: Kanazaki, Kengo, et al.
Publicado: (2016)

sFlt Multivalent Conjugates Inhibit Angiogenesis and Improve Half-Life In Vivo
por: Altiok, Eda I., et al.
Publicado: (2016)

Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin
por: Wu, Yue, et al.
Publicado: (2022)

Ubiquitin and SUMO conjugation as biomarkers of acute myeloid leukemias response to chemotherapies
por: Gâtel, Pierre, et al.
Publicado: (2020)

Multivalent Antiviral XTEN–Peptide Conjugates with Long in Vivo Half-Life and Enhanced Solubility
por: Ding, Sheng, et al.
Publicado: (2014)

Preference of Conjugated Bile Acids over Unconjugated Bile Acids as Substrates for OATP1B1 and OATP1B3
por: Suga, Takahiro, et al.
Publicado: (2017)

CD16(+)NK-92 and anti-CD123 monoclonal antibody prolongs survival in primary human acute myeloid leukemia xenografted mice
por: Williams, Brent A., et al.
Publicado: (2018)

Gemtuzumab ozogamicin and novel antibody-drug conjugates in clinical trials for acute myeloid leukemia
por: Yu, Bo, et al.
Publicado: (2019)

Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer Antibody-Drug Conjugates (ADCs)
por: Hoffmann, Ricarda M., et al.
Publicado: (2020)

Safety and immunogenicity of a multivalent pneumococcal conjugate vaccine given with 13-valent pneumococcal conjugate vaccine in healthy infants: A phase 2 randomized trial
por: Simon, Michael W., et al.
Publicado: (2023)

Multivalency Increases the Binding Strength of RGD Peptidomimetic‐Paclitaxel Conjugates to Integrin α(V)β(3)
por: Raposo Moreira Dias, André, et al.
Publicado: (2017)

Structural Optimization of Foldamer-Dendrimer Conjugates as Multivalent Agents against the Toxic Effects of Amyloid Beta Oligomers
por: Bartus, Éva, et al.
Publicado: (2018)

Selective Capture of Anti‐N‐glucosylated NTHi Adhesin Peptide Antibodies by a Multivalent Dextran Conjugate
por: Mazzoleni, Antonio, et al.
Publicado: (2021)

Optimization of the Process for Preparing Bivalent Polysaccharide Conjugates to Develop Multivalent Conjugate Vaccines against Streptococcus pneumoniae or Neisseria meningitidis and Comparison with the Corresponding Licensed Vaccines in Animal Models
por: Huang, Fang, et al.
Publicado: (2023)

Valence-controlled protein conjugation on nanoparticles via re-arrangeable multivalent interactions of tandem repeat protein chains
por: Choi, Hyeongjoo, et al.
Publicado: (2022)

Longitudinal multiparameter single-cell analysis of macaques immunized with pneumococcal protein-conjugated or unconjugated polysaccharide vaccines reveals distinct antigen specific memory B cell repertoires
por: Jia, Bin, et al.
Publicado: (2017)

An inhibitor of ubiquitin conjugation and aggresome formation
por: An, Heeseon, et al.
Publicado: (2015)

Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia
por: Leipold, Douglas D., et al.
Publicado: (2018)

Nanoparticle-conjugated animal venom-toxins and their possible therapeutic potential
por: Biswas, Archita, et al.
Publicado: (2012)

A multivalent biparatopic EGFR-targeting nanobody drug conjugate displays potent anticancer activity in solid tumor models
por: Fan, Jiansheng, et al.
Publicado: (2021)

A radiolabeled antibody targeting CD123(+) leukemia stem cells – initial radioimmunotherapy studies in NOD/SCID mice engrafted with primary human AML
por: Leyton, Jeffrey V., et al.
Publicado: (2015)

Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy
por: Hingorani, Dina V., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lvnl0ik6oselac2bp6ncj7efqh