Cargando…

Association between Thyroid-Stimulating Hormone Level after Total Thyroidectomy and Hypercholesterolemia in Female Patients with Differentiated Thyroid Cancer: A Retrospective Study

Less-intense TSH suppression strategies can be used for differentiated thyroid cancer (DTC) patients with a low recurrence risk, but their metabolic outcomes are not well known. We aimed to evaluate changes in the serum cholesterol levels and the risk of hypercholesterolemia according to postoperati...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Young Ki, Lee, Hokyou, Han, Seunghee, Jung, Hyein, Shin, Dong Yeob, Nam, Kee-Hyun, Chung, Woong Youn, Lee, Eun Jig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723726/
https://www.ncbi.nlm.nih.gov/pubmed/31349714
http://dx.doi.org/10.3390/jcm8081106
_version_ 1783448837229117440
author Lee, Young Ki
Lee, Hokyou
Han, Seunghee
Jung, Hyein
Shin, Dong Yeob
Nam, Kee-Hyun
Chung, Woong Youn
Lee, Eun Jig
author_facet Lee, Young Ki
Lee, Hokyou
Han, Seunghee
Jung, Hyein
Shin, Dong Yeob
Nam, Kee-Hyun
Chung, Woong Youn
Lee, Eun Jig
author_sort Lee, Young Ki
collection PubMed
description Less-intense TSH suppression strategies can be used for differentiated thyroid cancer (DTC) patients with a low recurrence risk, but their metabolic outcomes are not well known. We aimed to evaluate changes in the serum cholesterol levels and the risk of hypercholesterolemia according to postoperative TSH levels in 1092 female DTC patients receiving levothyroxine after total thyroidectomy. The preoperative-to-follow-up change in total cholesterol (TC) levels in the TSH level <0.03, 0.03–0.3, 0.3–2, and 2–5 mIU/L groups was −3.69 mg/dL (p = 0.006), +0.13 mg/dL (p = 0.926), +12.46 mg/dL (p < 0.001), and +16.46 mg/dL (p < 0.001), respectively. When compared with TSH levels of 0.03–0.3 mIU/L, those of 0.3–2 mIU/L were found to be associated with hypercholesterolemia (adjusted odds ratio (AOR) = 1.86 and 5.08 for TC 200–240 and ≥240 vs. <200 mg/dL) and hyper-low-density lipoprotein (LDL)-cholesterolemia (AOR = 2.76 for LDL-cholesterol ≥160 vs. <130 mg/dL). Additionally, TSH levels of 2–5 mIU/dL were associated with hypercholesterolemia (AOR = 2.85 and 6.95 for TC 200–240 and ≥240 vs. <200 mg/dL) and hyper-LDL-cholesterolemia (AOR = 2.08 and 4.17 for LDL-cholesterol 130–159 and ≥160 mg/dL vs. <130 mg/dL). In patients with normal TSH level maintenance following thyroidectomy, TC levels markedly increased, resulting in an increased hypercholesterolemia prevalence. Metabolic derangement risk due to insufficient levothyroxine replacement should be considered in the adoption of less-intense TSH suppression strategies, postoperatively, in DTC patients.
format Online
Article
Text
id pubmed-6723726
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-67237262019-09-10 Association between Thyroid-Stimulating Hormone Level after Total Thyroidectomy and Hypercholesterolemia in Female Patients with Differentiated Thyroid Cancer: A Retrospective Study Lee, Young Ki Lee, Hokyou Han, Seunghee Jung, Hyein Shin, Dong Yeob Nam, Kee-Hyun Chung, Woong Youn Lee, Eun Jig J Clin Med Article Less-intense TSH suppression strategies can be used for differentiated thyroid cancer (DTC) patients with a low recurrence risk, but their metabolic outcomes are not well known. We aimed to evaluate changes in the serum cholesterol levels and the risk of hypercholesterolemia according to postoperative TSH levels in 1092 female DTC patients receiving levothyroxine after total thyroidectomy. The preoperative-to-follow-up change in total cholesterol (TC) levels in the TSH level <0.03, 0.03–0.3, 0.3–2, and 2–5 mIU/L groups was −3.69 mg/dL (p = 0.006), +0.13 mg/dL (p = 0.926), +12.46 mg/dL (p < 0.001), and +16.46 mg/dL (p < 0.001), respectively. When compared with TSH levels of 0.03–0.3 mIU/L, those of 0.3–2 mIU/L were found to be associated with hypercholesterolemia (adjusted odds ratio (AOR) = 1.86 and 5.08 for TC 200–240 and ≥240 vs. <200 mg/dL) and hyper-low-density lipoprotein (LDL)-cholesterolemia (AOR = 2.76 for LDL-cholesterol ≥160 vs. <130 mg/dL). Additionally, TSH levels of 2–5 mIU/dL were associated with hypercholesterolemia (AOR = 2.85 and 6.95 for TC 200–240 and ≥240 vs. <200 mg/dL) and hyper-LDL-cholesterolemia (AOR = 2.08 and 4.17 for LDL-cholesterol 130–159 and ≥160 mg/dL vs. <130 mg/dL). In patients with normal TSH level maintenance following thyroidectomy, TC levels markedly increased, resulting in an increased hypercholesterolemia prevalence. Metabolic derangement risk due to insufficient levothyroxine replacement should be considered in the adoption of less-intense TSH suppression strategies, postoperatively, in DTC patients. MDPI 2019-07-25 /pmc/articles/PMC6723726/ /pubmed/31349714 http://dx.doi.org/10.3390/jcm8081106 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Young Ki
Lee, Hokyou
Han, Seunghee
Jung, Hyein
Shin, Dong Yeob
Nam, Kee-Hyun
Chung, Woong Youn
Lee, Eun Jig
Association between Thyroid-Stimulating Hormone Level after Total Thyroidectomy and Hypercholesterolemia in Female Patients with Differentiated Thyroid Cancer: A Retrospective Study
title Association between Thyroid-Stimulating Hormone Level after Total Thyroidectomy and Hypercholesterolemia in Female Patients with Differentiated Thyroid Cancer: A Retrospective Study
title_full Association between Thyroid-Stimulating Hormone Level after Total Thyroidectomy and Hypercholesterolemia in Female Patients with Differentiated Thyroid Cancer: A Retrospective Study
title_fullStr Association between Thyroid-Stimulating Hormone Level after Total Thyroidectomy and Hypercholesterolemia in Female Patients with Differentiated Thyroid Cancer: A Retrospective Study
title_full_unstemmed Association between Thyroid-Stimulating Hormone Level after Total Thyroidectomy and Hypercholesterolemia in Female Patients with Differentiated Thyroid Cancer: A Retrospective Study
title_short Association between Thyroid-Stimulating Hormone Level after Total Thyroidectomy and Hypercholesterolemia in Female Patients with Differentiated Thyroid Cancer: A Retrospective Study
title_sort association between thyroid-stimulating hormone level after total thyroidectomy and hypercholesterolemia in female patients with differentiated thyroid cancer: a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723726/
https://www.ncbi.nlm.nih.gov/pubmed/31349714
http://dx.doi.org/10.3390/jcm8081106
work_keys_str_mv AT leeyoungki associationbetweenthyroidstimulatinghormonelevelaftertotalthyroidectomyandhypercholesterolemiainfemalepatientswithdifferentiatedthyroidcanceraretrospectivestudy
AT leehokyou associationbetweenthyroidstimulatinghormonelevelaftertotalthyroidectomyandhypercholesterolemiainfemalepatientswithdifferentiatedthyroidcanceraretrospectivestudy
AT hanseunghee associationbetweenthyroidstimulatinghormonelevelaftertotalthyroidectomyandhypercholesterolemiainfemalepatientswithdifferentiatedthyroidcanceraretrospectivestudy
AT junghyein associationbetweenthyroidstimulatinghormonelevelaftertotalthyroidectomyandhypercholesterolemiainfemalepatientswithdifferentiatedthyroidcanceraretrospectivestudy
AT shindongyeob associationbetweenthyroidstimulatinghormonelevelaftertotalthyroidectomyandhypercholesterolemiainfemalepatientswithdifferentiatedthyroidcanceraretrospectivestudy
AT namkeehyun associationbetweenthyroidstimulatinghormonelevelaftertotalthyroidectomyandhypercholesterolemiainfemalepatientswithdifferentiatedthyroidcanceraretrospectivestudy
AT chungwoongyoun associationbetweenthyroidstimulatinghormonelevelaftertotalthyroidectomyandhypercholesterolemiainfemalepatientswithdifferentiatedthyroidcanceraretrospectivestudy
AT leeeunjig associationbetweenthyroidstimulatinghormonelevelaftertotalthyroidectomyandhypercholesterolemiainfemalepatientswithdifferentiatedthyroidcanceraretrospectivestudy