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Scale-Up Synthesis and In Vivo Anti-Tumor Activity of Curcumin Diethyl Disuccinate, an Ester Prodrug of Curcumin, in HepG2-Xenograft Mice

Previously, we synthesized curcumin and a succinate ester prodrug of curcumin namely curcumin diethyl disuccinate (CurDD) in the lab scale, which yielded hundred milligrams to few grams of the compounds. CurDD was found to be more stable in a phosphate buffer pH 7.4 and exhibited better cytotoxicity...

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Detalles Bibliográficos
Autores principales:	Muangnoi, Chawanphat, Ratnatilaka Na Bhuket, Pahweenvaj, Jithavech, Ponsiree, Wichitnithad, Wisut, Srikun, Onsiri, Nerungsi, Chakkrapan, Patumraj, Suthiluk, Rojsitthisak, Pornchai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723761/ https://www.ncbi.nlm.nih.gov/pubmed/31374932 http://dx.doi.org/10.3390/pharmaceutics11080373

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