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Measles Elimination: Identifying Susceptible Sub-Populations to Tailor Immunization Strategies

Measles elimination has been identified as a public health priority in Europe for a long time but has not yet been achieved. The World Health Organization (WHO) recommends identification of susceptible sub-populations to target supplementary immunization activities. We used three different sources o...

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Autores principales: Kreidl, Peter, Ammerer, David, Würzner, Reinhard, Luckner Hornischer, Anita, von Laer, Dorothee, Borena, Wegene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723762/
https://www.ncbi.nlm.nih.gov/pubmed/31434243
http://dx.doi.org/10.3390/v11080765
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author Kreidl, Peter
Ammerer, David
Würzner, Reinhard
Luckner Hornischer, Anita
von Laer, Dorothee
Borena, Wegene
author_facet Kreidl, Peter
Ammerer, David
Würzner, Reinhard
Luckner Hornischer, Anita
von Laer, Dorothee
Borena, Wegene
author_sort Kreidl, Peter
collection PubMed
description Measles elimination has been identified as a public health priority in Europe for a long time but has not yet been achieved. The World Health Organization (WHO) recommends identification of susceptible sub-populations to target supplementary immunization activities. We used three different sources of information: retrospective samples investigated for measles IgG between 1997 and 2016, vaccine coverage data from the existing electronic registry for birth cohorts 2015 to 1999, and surveillance data from 2009 until 20 July 2019. We calculated susceptibility by birth cohort using seroprevalence data, adjusting vaccine coverage data with reported effectiveness (93% for the first and 97% for the second dose, respectively), and compared it with measles incidence data, aggregated by birth cohorts and districts. Susceptibility levels for persons 10–41 years (birth cohorts 2007–1976) were 10.4% and thus far above the recommended values of WHO (5%). Older birth cohorts were sufficiently protected. Districts with the highest susceptibility estimates corresponded with districts with the highest incidence rates. Birth cohorts with susceptibility levels > 10% showed a 4.7 increased relative risk of having had more than one measles case. We conclude that retrospective serosurveys are a cheap and useful approach in identifying susceptible sub-populations, especially for older birth cohorts whose coverage data remain scarce.
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spelling pubmed-67237622019-09-10 Measles Elimination: Identifying Susceptible Sub-Populations to Tailor Immunization Strategies Kreidl, Peter Ammerer, David Würzner, Reinhard Luckner Hornischer, Anita von Laer, Dorothee Borena, Wegene Viruses Communication Measles elimination has been identified as a public health priority in Europe for a long time but has not yet been achieved. The World Health Organization (WHO) recommends identification of susceptible sub-populations to target supplementary immunization activities. We used three different sources of information: retrospective samples investigated for measles IgG between 1997 and 2016, vaccine coverage data from the existing electronic registry for birth cohorts 2015 to 1999, and surveillance data from 2009 until 20 July 2019. We calculated susceptibility by birth cohort using seroprevalence data, adjusting vaccine coverage data with reported effectiveness (93% for the first and 97% for the second dose, respectively), and compared it with measles incidence data, aggregated by birth cohorts and districts. Susceptibility levels for persons 10–41 years (birth cohorts 2007–1976) were 10.4% and thus far above the recommended values of WHO (5%). Older birth cohorts were sufficiently protected. Districts with the highest susceptibility estimates corresponded with districts with the highest incidence rates. Birth cohorts with susceptibility levels > 10% showed a 4.7 increased relative risk of having had more than one measles case. We conclude that retrospective serosurveys are a cheap and useful approach in identifying susceptible sub-populations, especially for older birth cohorts whose coverage data remain scarce. MDPI 2019-08-20 /pmc/articles/PMC6723762/ /pubmed/31434243 http://dx.doi.org/10.3390/v11080765 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Kreidl, Peter
Ammerer, David
Würzner, Reinhard
Luckner Hornischer, Anita
von Laer, Dorothee
Borena, Wegene
Measles Elimination: Identifying Susceptible Sub-Populations to Tailor Immunization Strategies
title Measles Elimination: Identifying Susceptible Sub-Populations to Tailor Immunization Strategies
title_full Measles Elimination: Identifying Susceptible Sub-Populations to Tailor Immunization Strategies
title_fullStr Measles Elimination: Identifying Susceptible Sub-Populations to Tailor Immunization Strategies
title_full_unstemmed Measles Elimination: Identifying Susceptible Sub-Populations to Tailor Immunization Strategies
title_short Measles Elimination: Identifying Susceptible Sub-Populations to Tailor Immunization Strategies
title_sort measles elimination: identifying susceptible sub-populations to tailor immunization strategies
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723762/
https://www.ncbi.nlm.nih.gov/pubmed/31434243
http://dx.doi.org/10.3390/v11080765
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