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Investigating Stress Response during Vaginal Delivery and Elective Cesarean Section through Assessment of Levels of Cortisol, Interleukin 6 (IL-6), Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1)

Background: How do stress related phenomena during labor differ between vaginal delivery (VD) and elective cesarean section (CS), remains of heightened interest. The purpose of this study is to investigate discrepancies regarding the stress response during VD and CS. Methods: Cortisol, interleukin 6...

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Autores principales: Kiriakopoulos, Nikolaos, Grigoriadis, Sokratis, Maziotis, Evangelos, Philippou, Anastasios, Rapani, Anna, Giannelou, Polina, Tsioulou, Petroula, Sfakianoudis, Konstantinos, Kontogeorgi, Adamantia, Bakas, Panagiotis, Mastorakos, George, Koutsilieris, Michael, Simopoulou, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723771/
https://www.ncbi.nlm.nih.gov/pubmed/31357604
http://dx.doi.org/10.3390/jcm8081112
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author Kiriakopoulos, Nikolaos
Grigoriadis, Sokratis
Maziotis, Evangelos
Philippou, Anastasios
Rapani, Anna
Giannelou, Polina
Tsioulou, Petroula
Sfakianoudis, Konstantinos
Kontogeorgi, Adamantia
Bakas, Panagiotis
Mastorakos, George
Koutsilieris, Michael
Simopoulou, Mara
author_facet Kiriakopoulos, Nikolaos
Grigoriadis, Sokratis
Maziotis, Evangelos
Philippou, Anastasios
Rapani, Anna
Giannelou, Polina
Tsioulou, Petroula
Sfakianoudis, Konstantinos
Kontogeorgi, Adamantia
Bakas, Panagiotis
Mastorakos, George
Koutsilieris, Michael
Simopoulou, Mara
author_sort Kiriakopoulos, Nikolaos
collection PubMed
description Background: How do stress related phenomena during labor differ between vaginal delivery (VD) and elective cesarean section (CS), remains of heightened interest. The purpose of this study is to investigate discrepancies regarding the stress response during VD and CS. Methods: Cortisol, interleukin 6 (IL-6), growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels from parturients’ peripheral blood were evaluated on three time-points, namely during the first stage of labor (TP1), two hours post labor (TP2) and 48 h post labor (TP3). Levels were also evaluated from the umbilical cord blood. A total of 50 women were enrolled in this prospective cohort study, with 24 and 26 subjected to CS and VD, respectively. Results: No statistically significant differences were observed between the two groups at TP1. Only GH levels presented the same pattern during the three time-points among both groups. In the umbilical cord blood, the CS group presented statistically significant higher IGF-1 and GH levels. In the umbilical cord blood, IGF-1 and GH levels were positively correlated, while GH and cortisol levels were negatively correlated. Conclusion: CS is a less stressful procedure than VD and is further associated with less intense inflammation, albeit with a longer inflammatory response period. Labor physiology during CS differs considerably regarding respective observations during VD. This merits extensive investigation in order to decipher these data for optimal clinical practice and guidelines.
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spelling pubmed-67237712019-09-10 Investigating Stress Response during Vaginal Delivery and Elective Cesarean Section through Assessment of Levels of Cortisol, Interleukin 6 (IL-6), Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1) Kiriakopoulos, Nikolaos Grigoriadis, Sokratis Maziotis, Evangelos Philippou, Anastasios Rapani, Anna Giannelou, Polina Tsioulou, Petroula Sfakianoudis, Konstantinos Kontogeorgi, Adamantia Bakas, Panagiotis Mastorakos, George Koutsilieris, Michael Simopoulou, Mara J Clin Med Article Background: How do stress related phenomena during labor differ between vaginal delivery (VD) and elective cesarean section (CS), remains of heightened interest. The purpose of this study is to investigate discrepancies regarding the stress response during VD and CS. Methods: Cortisol, interleukin 6 (IL-6), growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels from parturients’ peripheral blood were evaluated on three time-points, namely during the first stage of labor (TP1), two hours post labor (TP2) and 48 h post labor (TP3). Levels were also evaluated from the umbilical cord blood. A total of 50 women were enrolled in this prospective cohort study, with 24 and 26 subjected to CS and VD, respectively. Results: No statistically significant differences were observed between the two groups at TP1. Only GH levels presented the same pattern during the three time-points among both groups. In the umbilical cord blood, the CS group presented statistically significant higher IGF-1 and GH levels. In the umbilical cord blood, IGF-1 and GH levels were positively correlated, while GH and cortisol levels were negatively correlated. Conclusion: CS is a less stressful procedure than VD and is further associated with less intense inflammation, albeit with a longer inflammatory response period. Labor physiology during CS differs considerably regarding respective observations during VD. This merits extensive investigation in order to decipher these data for optimal clinical practice and guidelines. MDPI 2019-07-27 /pmc/articles/PMC6723771/ /pubmed/31357604 http://dx.doi.org/10.3390/jcm8081112 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kiriakopoulos, Nikolaos
Grigoriadis, Sokratis
Maziotis, Evangelos
Philippou, Anastasios
Rapani, Anna
Giannelou, Polina
Tsioulou, Petroula
Sfakianoudis, Konstantinos
Kontogeorgi, Adamantia
Bakas, Panagiotis
Mastorakos, George
Koutsilieris, Michael
Simopoulou, Mara
Investigating Stress Response during Vaginal Delivery and Elective Cesarean Section through Assessment of Levels of Cortisol, Interleukin 6 (IL-6), Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1)
title Investigating Stress Response during Vaginal Delivery and Elective Cesarean Section through Assessment of Levels of Cortisol, Interleukin 6 (IL-6), Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1)
title_full Investigating Stress Response during Vaginal Delivery and Elective Cesarean Section through Assessment of Levels of Cortisol, Interleukin 6 (IL-6), Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1)
title_fullStr Investigating Stress Response during Vaginal Delivery and Elective Cesarean Section through Assessment of Levels of Cortisol, Interleukin 6 (IL-6), Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1)
title_full_unstemmed Investigating Stress Response during Vaginal Delivery and Elective Cesarean Section through Assessment of Levels of Cortisol, Interleukin 6 (IL-6), Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1)
title_short Investigating Stress Response during Vaginal Delivery and Elective Cesarean Section through Assessment of Levels of Cortisol, Interleukin 6 (IL-6), Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1)
title_sort investigating stress response during vaginal delivery and elective cesarean section through assessment of levels of cortisol, interleukin 6 (il-6), growth hormone (gh) and insulin-like growth factor 1 (igf-1)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723771/
https://www.ncbi.nlm.nih.gov/pubmed/31357604
http://dx.doi.org/10.3390/jcm8081112
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