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Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome

Women with polycystic ovary syndrome (PCOS) exhibit compromised psychiatric health. Independent of obesity, women with PCOS are more susceptible to have anxiety and depression diagnoses and other neuropsychiatric disorders. During pregnancy women with PCOS display high circulating androgen levels th...

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Autores principales: Stener-Victorin, Elisabet, Manti, Maria, Fornes, Romina, Risal, Sanjiv, Lu, Haojiang, Benrick, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723772/
https://www.ncbi.nlm.nih.gov/pubmed/31387252
http://dx.doi.org/10.3390/medsci7080086
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author Stener-Victorin, Elisabet
Manti, Maria
Fornes, Romina
Risal, Sanjiv
Lu, Haojiang
Benrick, Anna
author_facet Stener-Victorin, Elisabet
Manti, Maria
Fornes, Romina
Risal, Sanjiv
Lu, Haojiang
Benrick, Anna
author_sort Stener-Victorin, Elisabet
collection PubMed
description Women with polycystic ovary syndrome (PCOS) exhibit compromised psychiatric health. Independent of obesity, women with PCOS are more susceptible to have anxiety and depression diagnoses and other neuropsychiatric disorders. During pregnancy women with PCOS display high circulating androgen levels that may cause prenatal androgen exposure affecting the growing fetus and increasing the risk of mood disorders in offspring. Increasing evidence supports a non-genetic, maternal contribution to the development of PCOS and anxiety disorders in the next generation. Prenatal androgenized rodent models reflecting the anxiety-like phenotype of PCOS in the offspring, found evidence for the altered placenta and androgen receptor function in the amygdala, together with changes in the expression of genes associated with emotional regulation and steroid receptors in the amygdala and hippocampus. These findings defined a previously unknown mechanism that may be critical in understanding how maternal androgen excess can increase the risk of developing anxiety disorders in daughters and partly in sons of PCOS mothers. Maternal obesity is another common feature of PCOS causing an unfavorable intrauterine environment which may contribute to psychiatric problems in the offspring. Whether environmental factors such as prenatal androgen exposure and obesity increase the offspring’s susceptibility to develop psychiatric ill-health will be discussed.
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spelling pubmed-67237722019-09-10 Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome Stener-Victorin, Elisabet Manti, Maria Fornes, Romina Risal, Sanjiv Lu, Haojiang Benrick, Anna Med Sci (Basel) Review Women with polycystic ovary syndrome (PCOS) exhibit compromised psychiatric health. Independent of obesity, women with PCOS are more susceptible to have anxiety and depression diagnoses and other neuropsychiatric disorders. During pregnancy women with PCOS display high circulating androgen levels that may cause prenatal androgen exposure affecting the growing fetus and increasing the risk of mood disorders in offspring. Increasing evidence supports a non-genetic, maternal contribution to the development of PCOS and anxiety disorders in the next generation. Prenatal androgenized rodent models reflecting the anxiety-like phenotype of PCOS in the offspring, found evidence for the altered placenta and androgen receptor function in the amygdala, together with changes in the expression of genes associated with emotional regulation and steroid receptors in the amygdala and hippocampus. These findings defined a previously unknown mechanism that may be critical in understanding how maternal androgen excess can increase the risk of developing anxiety disorders in daughters and partly in sons of PCOS mothers. Maternal obesity is another common feature of PCOS causing an unfavorable intrauterine environment which may contribute to psychiatric problems in the offspring. Whether environmental factors such as prenatal androgen exposure and obesity increase the offspring’s susceptibility to develop psychiatric ill-health will be discussed. MDPI 2019-08-05 /pmc/articles/PMC6723772/ /pubmed/31387252 http://dx.doi.org/10.3390/medsci7080086 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stener-Victorin, Elisabet
Manti, Maria
Fornes, Romina
Risal, Sanjiv
Lu, Haojiang
Benrick, Anna
Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome
title Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome
title_full Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome
title_fullStr Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome
title_full_unstemmed Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome
title_short Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome
title_sort origins and impact of psychological traits in polycystic ovary syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723772/
https://www.ncbi.nlm.nih.gov/pubmed/31387252
http://dx.doi.org/10.3390/medsci7080086
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