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Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry
Background and objectives: The overlap between antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (ANCA-GN) and connective tissue diseases (CTD) has been reported mainly as case series in the literature. Frequency of this association, as well as presentation and outcomes are un...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723780/ https://www.ncbi.nlm.nih.gov/pubmed/31416296 http://dx.doi.org/10.3390/jcm8081218 |
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author | Guibert, Fanny Garnier, Anne-Sophie Wacrenier, Samuel Piccoli, Giorgina Djema, Assia Gansey, Renaud Demiselle, Julien Brilland, Benoit Cousin, Maud Besson, Virginie Duveau, Agnès El Nasser, Khuzama Coindre, Jean-Philippe Croue, Anne Saint-André, Jean-Paul Chevailler, Alain Subra, Jean-François Augusto, Jean-François |
author_facet | Guibert, Fanny Garnier, Anne-Sophie Wacrenier, Samuel Piccoli, Giorgina Djema, Assia Gansey, Renaud Demiselle, Julien Brilland, Benoit Cousin, Maud Besson, Virginie Duveau, Agnès El Nasser, Khuzama Coindre, Jean-Philippe Croue, Anne Saint-André, Jean-Paul Chevailler, Alain Subra, Jean-François Augusto, Jean-François |
author_sort | Guibert, Fanny |
collection | PubMed |
description | Background and objectives: The overlap between antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (ANCA-GN) and connective tissue diseases (CTD) has been reported mainly as case series in the literature. Frequency of this association, as well as presentation and outcomes are unknown. Materials and Methods: Patients from the Maine-Anjou ANCA-associated vasculitides (AAV) registry with ANCA-GN diagnosed between 01/01/2000 and 01/01/2018, ANCA positivity, and at least six months of follow-up, were included. Results: 106 out of 142 patients fulfilled the inclusion criteria and were analyzed. CTD was present at ANCA-GN diagnosis in 16 (15.1%) patients. The most common CTD were rheumatoid arthritis, Sjogren syndrome and systemic sclerosis. Compared to the control group, females were more represented in the CTD group (75%, p = 0.001). Renal presentation was comparable between groups, including the pathological analysis of renal biopsies. Patients of CTD group presented a higher rate of non-renal relapse (25% versus 7.7%, p = 0.037), and experienced more frequently a venous thrombotic event (31.2% versus 10%, p = 0.021). No difference between groups was observed according to major outcomes. Conclusion: Association between CTD and ANCA-GN is not a rare condition and predominantly affects females. While AAV presentation is not significantly different, CTD patients experience more frequently non-renal relapse and venous thrombotic events. |
format | Online Article Text |
id | pubmed-6723780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67237802019-09-10 Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry Guibert, Fanny Garnier, Anne-Sophie Wacrenier, Samuel Piccoli, Giorgina Djema, Assia Gansey, Renaud Demiselle, Julien Brilland, Benoit Cousin, Maud Besson, Virginie Duveau, Agnès El Nasser, Khuzama Coindre, Jean-Philippe Croue, Anne Saint-André, Jean-Paul Chevailler, Alain Subra, Jean-François Augusto, Jean-François J Clin Med Article Background and objectives: The overlap between antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (ANCA-GN) and connective tissue diseases (CTD) has been reported mainly as case series in the literature. Frequency of this association, as well as presentation and outcomes are unknown. Materials and Methods: Patients from the Maine-Anjou ANCA-associated vasculitides (AAV) registry with ANCA-GN diagnosed between 01/01/2000 and 01/01/2018, ANCA positivity, and at least six months of follow-up, were included. Results: 106 out of 142 patients fulfilled the inclusion criteria and were analyzed. CTD was present at ANCA-GN diagnosis in 16 (15.1%) patients. The most common CTD were rheumatoid arthritis, Sjogren syndrome and systemic sclerosis. Compared to the control group, females were more represented in the CTD group (75%, p = 0.001). Renal presentation was comparable between groups, including the pathological analysis of renal biopsies. Patients of CTD group presented a higher rate of non-renal relapse (25% versus 7.7%, p = 0.037), and experienced more frequently a venous thrombotic event (31.2% versus 10%, p = 0.021). No difference between groups was observed according to major outcomes. Conclusion: Association between CTD and ANCA-GN is not a rare condition and predominantly affects females. While AAV presentation is not significantly different, CTD patients experience more frequently non-renal relapse and venous thrombotic events. MDPI 2019-08-14 /pmc/articles/PMC6723780/ /pubmed/31416296 http://dx.doi.org/10.3390/jcm8081218 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Guibert, Fanny Garnier, Anne-Sophie Wacrenier, Samuel Piccoli, Giorgina Djema, Assia Gansey, Renaud Demiselle, Julien Brilland, Benoit Cousin, Maud Besson, Virginie Duveau, Agnès El Nasser, Khuzama Coindre, Jean-Philippe Croue, Anne Saint-André, Jean-Paul Chevailler, Alain Subra, Jean-François Augusto, Jean-François Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry |
title | Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry |
title_full | Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry |
title_fullStr | Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry |
title_full_unstemmed | Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry |
title_short | Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry |
title_sort | patients with anca-associated glomerulonephritis and connective tissue diseases: a comparative study from the maine-anjou aav registry |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723780/ https://www.ncbi.nlm.nih.gov/pubmed/31416296 http://dx.doi.org/10.3390/jcm8081218 |
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