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Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry

Background and objectives: The overlap between antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (ANCA-GN) and connective tissue diseases (CTD) has been reported mainly as case series in the literature. Frequency of this association, as well as presentation and outcomes are un...

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Autores principales: Guibert, Fanny, Garnier, Anne-Sophie, Wacrenier, Samuel, Piccoli, Giorgina, Djema, Assia, Gansey, Renaud, Demiselle, Julien, Brilland, Benoit, Cousin, Maud, Besson, Virginie, Duveau, Agnès, El Nasser, Khuzama, Coindre, Jean-Philippe, Croue, Anne, Saint-André, Jean-Paul, Chevailler, Alain, Subra, Jean-François, Augusto, Jean-François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723780/
https://www.ncbi.nlm.nih.gov/pubmed/31416296
http://dx.doi.org/10.3390/jcm8081218
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author Guibert, Fanny
Garnier, Anne-Sophie
Wacrenier, Samuel
Piccoli, Giorgina
Djema, Assia
Gansey, Renaud
Demiselle, Julien
Brilland, Benoit
Cousin, Maud
Besson, Virginie
Duveau, Agnès
El Nasser, Khuzama
Coindre, Jean-Philippe
Croue, Anne
Saint-André, Jean-Paul
Chevailler, Alain
Subra, Jean-François
Augusto, Jean-François
author_facet Guibert, Fanny
Garnier, Anne-Sophie
Wacrenier, Samuel
Piccoli, Giorgina
Djema, Assia
Gansey, Renaud
Demiselle, Julien
Brilland, Benoit
Cousin, Maud
Besson, Virginie
Duveau, Agnès
El Nasser, Khuzama
Coindre, Jean-Philippe
Croue, Anne
Saint-André, Jean-Paul
Chevailler, Alain
Subra, Jean-François
Augusto, Jean-François
author_sort Guibert, Fanny
collection PubMed
description Background and objectives: The overlap between antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (ANCA-GN) and connective tissue diseases (CTD) has been reported mainly as case series in the literature. Frequency of this association, as well as presentation and outcomes are unknown. Materials and Methods: Patients from the Maine-Anjou ANCA-associated vasculitides (AAV) registry with ANCA-GN diagnosed between 01/01/2000 and 01/01/2018, ANCA positivity, and at least six months of follow-up, were included. Results: 106 out of 142 patients fulfilled the inclusion criteria and were analyzed. CTD was present at ANCA-GN diagnosis in 16 (15.1%) patients. The most common CTD were rheumatoid arthritis, Sjogren syndrome and systemic sclerosis. Compared to the control group, females were more represented in the CTD group (75%, p = 0.001). Renal presentation was comparable between groups, including the pathological analysis of renal biopsies. Patients of CTD group presented a higher rate of non-renal relapse (25% versus 7.7%, p = 0.037), and experienced more frequently a venous thrombotic event (31.2% versus 10%, p = 0.021). No difference between groups was observed according to major outcomes. Conclusion: Association between CTD and ANCA-GN is not a rare condition and predominantly affects females. While AAV presentation is not significantly different, CTD patients experience more frequently non-renal relapse and venous thrombotic events.
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spelling pubmed-67237802019-09-10 Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry Guibert, Fanny Garnier, Anne-Sophie Wacrenier, Samuel Piccoli, Giorgina Djema, Assia Gansey, Renaud Demiselle, Julien Brilland, Benoit Cousin, Maud Besson, Virginie Duveau, Agnès El Nasser, Khuzama Coindre, Jean-Philippe Croue, Anne Saint-André, Jean-Paul Chevailler, Alain Subra, Jean-François Augusto, Jean-François J Clin Med Article Background and objectives: The overlap between antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (ANCA-GN) and connective tissue diseases (CTD) has been reported mainly as case series in the literature. Frequency of this association, as well as presentation and outcomes are unknown. Materials and Methods: Patients from the Maine-Anjou ANCA-associated vasculitides (AAV) registry with ANCA-GN diagnosed between 01/01/2000 and 01/01/2018, ANCA positivity, and at least six months of follow-up, were included. Results: 106 out of 142 patients fulfilled the inclusion criteria and were analyzed. CTD was present at ANCA-GN diagnosis in 16 (15.1%) patients. The most common CTD were rheumatoid arthritis, Sjogren syndrome and systemic sclerosis. Compared to the control group, females were more represented in the CTD group (75%, p = 0.001). Renal presentation was comparable between groups, including the pathological analysis of renal biopsies. Patients of CTD group presented a higher rate of non-renal relapse (25% versus 7.7%, p = 0.037), and experienced more frequently a venous thrombotic event (31.2% versus 10%, p = 0.021). No difference between groups was observed according to major outcomes. Conclusion: Association between CTD and ANCA-GN is not a rare condition and predominantly affects females. While AAV presentation is not significantly different, CTD patients experience more frequently non-renal relapse and venous thrombotic events. MDPI 2019-08-14 /pmc/articles/PMC6723780/ /pubmed/31416296 http://dx.doi.org/10.3390/jcm8081218 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guibert, Fanny
Garnier, Anne-Sophie
Wacrenier, Samuel
Piccoli, Giorgina
Djema, Assia
Gansey, Renaud
Demiselle, Julien
Brilland, Benoit
Cousin, Maud
Besson, Virginie
Duveau, Agnès
El Nasser, Khuzama
Coindre, Jean-Philippe
Croue, Anne
Saint-André, Jean-Paul
Chevailler, Alain
Subra, Jean-François
Augusto, Jean-François
Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry
title Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry
title_full Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry
title_fullStr Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry
title_full_unstemmed Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry
title_short Patients with ANCA-Associated Glomerulonephritis and Connective Tissue Diseases: A Comparative Study from the Maine-Anjou AAV Registry
title_sort patients with anca-associated glomerulonephritis and connective tissue diseases: a comparative study from the maine-anjou aav registry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723780/
https://www.ncbi.nlm.nih.gov/pubmed/31416296
http://dx.doi.org/10.3390/jcm8081218
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