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Ionic Liquid-Polymer Nanoparticle Hybrid Systems as New Tools to Deliver Poorly Soluble Drugs

The use of functional excipients such as ionic liquids (ILs) and the encapsulation of drugs into nanocarriers are useful strategies to overcome poor drug solubility. The aim of this work was to evaluate the potential of IL-polymer nanoparticle hybrid systems as tools to deliver poorly soluble drugs....

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Autores principales: Júlio, Ana, Caparica, Rita, Costa Lima, Sofia A., Fernandes, Ana Sofia, Rosado, Catarina, Prazeres, Duarte M. F., Reis, Salette, Santos de Almeida, Tânia, Fonte, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723845/
https://www.ncbi.nlm.nih.gov/pubmed/31405123
http://dx.doi.org/10.3390/nano9081148
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author Júlio, Ana
Caparica, Rita
Costa Lima, Sofia A.
Fernandes, Ana Sofia
Rosado, Catarina
Prazeres, Duarte M. F.
Reis, Salette
Santos de Almeida, Tânia
Fonte, Pedro
author_facet Júlio, Ana
Caparica, Rita
Costa Lima, Sofia A.
Fernandes, Ana Sofia
Rosado, Catarina
Prazeres, Duarte M. F.
Reis, Salette
Santos de Almeida, Tânia
Fonte, Pedro
author_sort Júlio, Ana
collection PubMed
description The use of functional excipients such as ionic liquids (ILs) and the encapsulation of drugs into nanocarriers are useful strategies to overcome poor drug solubility. The aim of this work was to evaluate the potential of IL-polymer nanoparticle hybrid systems as tools to deliver poorly soluble drugs. These systems were obtained using a methodology previously developed by our group and improved herein to produce IL-polymer nanoparticle hybrid systems. Two different choline-based ILs and poly (lactic-co-glycolic acid) (PLGA) 50:50 or PLGA 75:25 were used to load rutin into the delivery system. The resulting rutin-loaded IL-polymer nanoparticle hybrid systems presented a diameter of 250–300 nm, with a low polydispersity index and a zeta potential of about −40 mV. The drug association efficiency ranged from 51% to 76%, which represents a good achievement considering the poor solubility of rutin. No significant particle aggregation was obtained upon freeze-drying. The presence of the IL in the nanosystem does not affect its sustained release properties, achieving about 85% of rutin released after 72 h. The cytotoxicity studies showed that the delivery system was not toxic to HaCat cells. Our findings may open a new paradigm on the therapy improvement of diseases treated with poorly soluble drugs.
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spelling pubmed-67238452019-09-10 Ionic Liquid-Polymer Nanoparticle Hybrid Systems as New Tools to Deliver Poorly Soluble Drugs Júlio, Ana Caparica, Rita Costa Lima, Sofia A. Fernandes, Ana Sofia Rosado, Catarina Prazeres, Duarte M. F. Reis, Salette Santos de Almeida, Tânia Fonte, Pedro Nanomaterials (Basel) Article The use of functional excipients such as ionic liquids (ILs) and the encapsulation of drugs into nanocarriers are useful strategies to overcome poor drug solubility. The aim of this work was to evaluate the potential of IL-polymer nanoparticle hybrid systems as tools to deliver poorly soluble drugs. These systems were obtained using a methodology previously developed by our group and improved herein to produce IL-polymer nanoparticle hybrid systems. Two different choline-based ILs and poly (lactic-co-glycolic acid) (PLGA) 50:50 or PLGA 75:25 were used to load rutin into the delivery system. The resulting rutin-loaded IL-polymer nanoparticle hybrid systems presented a diameter of 250–300 nm, with a low polydispersity index and a zeta potential of about −40 mV. The drug association efficiency ranged from 51% to 76%, which represents a good achievement considering the poor solubility of rutin. No significant particle aggregation was obtained upon freeze-drying. The presence of the IL in the nanosystem does not affect its sustained release properties, achieving about 85% of rutin released after 72 h. The cytotoxicity studies showed that the delivery system was not toxic to HaCat cells. Our findings may open a new paradigm on the therapy improvement of diseases treated with poorly soluble drugs. MDPI 2019-08-10 /pmc/articles/PMC6723845/ /pubmed/31405123 http://dx.doi.org/10.3390/nano9081148 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Júlio, Ana
Caparica, Rita
Costa Lima, Sofia A.
Fernandes, Ana Sofia
Rosado, Catarina
Prazeres, Duarte M. F.
Reis, Salette
Santos de Almeida, Tânia
Fonte, Pedro
Ionic Liquid-Polymer Nanoparticle Hybrid Systems as New Tools to Deliver Poorly Soluble Drugs
title Ionic Liquid-Polymer Nanoparticle Hybrid Systems as New Tools to Deliver Poorly Soluble Drugs
title_full Ionic Liquid-Polymer Nanoparticle Hybrid Systems as New Tools to Deliver Poorly Soluble Drugs
title_fullStr Ionic Liquid-Polymer Nanoparticle Hybrid Systems as New Tools to Deliver Poorly Soluble Drugs
title_full_unstemmed Ionic Liquid-Polymer Nanoparticle Hybrid Systems as New Tools to Deliver Poorly Soluble Drugs
title_short Ionic Liquid-Polymer Nanoparticle Hybrid Systems as New Tools to Deliver Poorly Soluble Drugs
title_sort ionic liquid-polymer nanoparticle hybrid systems as new tools to deliver poorly soluble drugs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723845/
https://www.ncbi.nlm.nih.gov/pubmed/31405123
http://dx.doi.org/10.3390/nano9081148
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