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Prediction of Transplant-Free Survival through Albumin-Bilirubin Score in Primary Biliary Cholangitis

Albumin–bilirubin (ALBI) grade is defined using the ALBI score, which is calculated based on total serum bilirubin and albumin. This study aimed to evaluate the diagnostic ability of the ALBI score for determining hepatic fibrosis stage and transplant-free survival in primary biliary cholangitis (PB...

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Autores principales: Fujita, Koji, Nomura, Takako, Morishita, Asahiro, Shi, Tingting, Oura, Kyoko, Tani, Joji, Kobara, Hideki, Tsutsui, Kunihiko, Himoto, Takashi, Masaki, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723915/
https://www.ncbi.nlm.nih.gov/pubmed/31430975
http://dx.doi.org/10.3390/jcm8081258
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author Fujita, Koji
Nomura, Takako
Morishita, Asahiro
Shi, Tingting
Oura, Kyoko
Tani, Joji
Kobara, Hideki
Tsutsui, Kunihiko
Himoto, Takashi
Masaki, Tsutomu
author_facet Fujita, Koji
Nomura, Takako
Morishita, Asahiro
Shi, Tingting
Oura, Kyoko
Tani, Joji
Kobara, Hideki
Tsutsui, Kunihiko
Himoto, Takashi
Masaki, Tsutomu
author_sort Fujita, Koji
collection PubMed
description Albumin–bilirubin (ALBI) grade is defined using the ALBI score, which is calculated based on total serum bilirubin and albumin. This study aimed to evaluate the diagnostic ability of the ALBI score for determining hepatic fibrosis stage and transplant-free survival in primary biliary cholangitis (PBC) patients. A total of 181 Japanese patients with biopsy-proven or serologically diagnosed PBC were enrolled. The pathological stage was assessed using the Scheuer classification. The ALBI score differentiated fibrosis in stage 4 from that of 3 in the biopsy-proven cohort (p < 0.05). With an ALBI score cut-off value of −1.679, the sensitivity and specificity were 100% and 91.1%, respectively, with a likelihood ratio of 12.3 to differentiate stage 4 from stages 1–3. The ALBI score at the beginning of ursodeoxycholic acid (UDCA) prescription correlated with the two prognostic scores calculated after 1-year UDCA treatment. Kaplan–Meier analysis showed that the baseline ALBI score differentiated liver transplant-free survival (p < 0.05). The ALBI score presented a greater hazard ratio for transplant-free survival than aspartate aminotransferase-to-platelet ratio index (APRI) in Cox proportional hazard model. In conclusion, ALBI score indicates pathological stage in Japanese PBC patients and scores before UDCA prescription predict better liver transplant-free survival, which correlated well with the two major prognostic scores. The prognosis-predicting ability of the ALBI score might surpass that of APRI.
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spelling pubmed-67239152019-09-10 Prediction of Transplant-Free Survival through Albumin-Bilirubin Score in Primary Biliary Cholangitis Fujita, Koji Nomura, Takako Morishita, Asahiro Shi, Tingting Oura, Kyoko Tani, Joji Kobara, Hideki Tsutsui, Kunihiko Himoto, Takashi Masaki, Tsutomu J Clin Med Article Albumin–bilirubin (ALBI) grade is defined using the ALBI score, which is calculated based on total serum bilirubin and albumin. This study aimed to evaluate the diagnostic ability of the ALBI score for determining hepatic fibrosis stage and transplant-free survival in primary biliary cholangitis (PBC) patients. A total of 181 Japanese patients with biopsy-proven or serologically diagnosed PBC were enrolled. The pathological stage was assessed using the Scheuer classification. The ALBI score differentiated fibrosis in stage 4 from that of 3 in the biopsy-proven cohort (p < 0.05). With an ALBI score cut-off value of −1.679, the sensitivity and specificity were 100% and 91.1%, respectively, with a likelihood ratio of 12.3 to differentiate stage 4 from stages 1–3. The ALBI score at the beginning of ursodeoxycholic acid (UDCA) prescription correlated with the two prognostic scores calculated after 1-year UDCA treatment. Kaplan–Meier analysis showed that the baseline ALBI score differentiated liver transplant-free survival (p < 0.05). The ALBI score presented a greater hazard ratio for transplant-free survival than aspartate aminotransferase-to-platelet ratio index (APRI) in Cox proportional hazard model. In conclusion, ALBI score indicates pathological stage in Japanese PBC patients and scores before UDCA prescription predict better liver transplant-free survival, which correlated well with the two major prognostic scores. The prognosis-predicting ability of the ALBI score might surpass that of APRI. MDPI 2019-08-19 /pmc/articles/PMC6723915/ /pubmed/31430975 http://dx.doi.org/10.3390/jcm8081258 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fujita, Koji
Nomura, Takako
Morishita, Asahiro
Shi, Tingting
Oura, Kyoko
Tani, Joji
Kobara, Hideki
Tsutsui, Kunihiko
Himoto, Takashi
Masaki, Tsutomu
Prediction of Transplant-Free Survival through Albumin-Bilirubin Score in Primary Biliary Cholangitis
title Prediction of Transplant-Free Survival through Albumin-Bilirubin Score in Primary Biliary Cholangitis
title_full Prediction of Transplant-Free Survival through Albumin-Bilirubin Score in Primary Biliary Cholangitis
title_fullStr Prediction of Transplant-Free Survival through Albumin-Bilirubin Score in Primary Biliary Cholangitis
title_full_unstemmed Prediction of Transplant-Free Survival through Albumin-Bilirubin Score in Primary Biliary Cholangitis
title_short Prediction of Transplant-Free Survival through Albumin-Bilirubin Score in Primary Biliary Cholangitis
title_sort prediction of transplant-free survival through albumin-bilirubin score in primary biliary cholangitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723915/
https://www.ncbi.nlm.nih.gov/pubmed/31430975
http://dx.doi.org/10.3390/jcm8081258
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