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Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study

Chronic kidney disease of unknown etiology (CKDu) imposes a substantial burden on public health in Sri Lankan agricultural communities. High seroprevalences of hantavirus have been reported in CKDu patients in several locations of Sri Lanka. We carried out a cross-sectional study followed by an unma...

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Autores principales: Sarathkumara, Yomani D., Gamage, Chandika D., Lokupathirage, Sithumini, Muthusinghe, Devinda S., Nanayakkara, Nishantha, Gunarathne, Lishanthe, Shimizu, Kenta, Tsuda, Yoshimi, Arikawa, Jiro, Yoshimatsu, Kumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723923/
https://www.ncbi.nlm.nih.gov/pubmed/31370348
http://dx.doi.org/10.3390/v11080700
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author Sarathkumara, Yomani D.
Gamage, Chandika D.
Lokupathirage, Sithumini
Muthusinghe, Devinda S.
Nanayakkara, Nishantha
Gunarathne, Lishanthe
Shimizu, Kenta
Tsuda, Yoshimi
Arikawa, Jiro
Yoshimatsu, Kumiko
author_facet Sarathkumara, Yomani D.
Gamage, Chandika D.
Lokupathirage, Sithumini
Muthusinghe, Devinda S.
Nanayakkara, Nishantha
Gunarathne, Lishanthe
Shimizu, Kenta
Tsuda, Yoshimi
Arikawa, Jiro
Yoshimatsu, Kumiko
author_sort Sarathkumara, Yomani D.
collection PubMed
description Chronic kidney disease of unknown etiology (CKDu) imposes a substantial burden on public health in Sri Lankan agricultural communities. High seroprevalences of hantavirus have been reported in CKDu patients in several locations of Sri Lanka. We carried out a cross-sectional study followed by an unmatched case-control comparison in two geographically distinct areas of Sri Lanka, Girandurukotte (CKDu endemic) and Kandy (CKDu non-endemic) to determine whether exposure to hantaviruses is a potential risk factor in patients with kidney disease. An indirect immunofluorescent antibody assay using two antigens, Thailand orthohantavirus-infected and recombinant N protein-expressing Vero E6 cells, were used for serodiagnosis. Participants’ demographic and other socio-economic data were collected through a structured questionnaire. Fifty kidney disease patients and 270 controls from Kandy and 104 kidney disease patients and 242 controls from Girandurukotte were examined. Seropositivities were 50% and 17.4% in kidney patients and controls, respectively, in Girandurukotte, and they were 18% and 7% in Kandy. The odds of exposure to hantaviruses were higher for kidney disease patients than for controls in both Girandurukotte (OR:3.66, 95% CI:2.01 to 6.64) and Kandy (OR:2.64, 95% CI:1.07 to 6.54) in binary logistic regression models. According to statistical analysis, individuals exposed to hantaviruses had a higher risk of developing renal impairment. Therefore, hantavirus infection might be an important risk factor for development of kidney disease in Sri Lanka.
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spelling pubmed-67239232019-09-10 Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study Sarathkumara, Yomani D. Gamage, Chandika D. Lokupathirage, Sithumini Muthusinghe, Devinda S. Nanayakkara, Nishantha Gunarathne, Lishanthe Shimizu, Kenta Tsuda, Yoshimi Arikawa, Jiro Yoshimatsu, Kumiko Viruses Article Chronic kidney disease of unknown etiology (CKDu) imposes a substantial burden on public health in Sri Lankan agricultural communities. High seroprevalences of hantavirus have been reported in CKDu patients in several locations of Sri Lanka. We carried out a cross-sectional study followed by an unmatched case-control comparison in two geographically distinct areas of Sri Lanka, Girandurukotte (CKDu endemic) and Kandy (CKDu non-endemic) to determine whether exposure to hantaviruses is a potential risk factor in patients with kidney disease. An indirect immunofluorescent antibody assay using two antigens, Thailand orthohantavirus-infected and recombinant N protein-expressing Vero E6 cells, were used for serodiagnosis. Participants’ demographic and other socio-economic data were collected through a structured questionnaire. Fifty kidney disease patients and 270 controls from Kandy and 104 kidney disease patients and 242 controls from Girandurukotte were examined. Seropositivities were 50% and 17.4% in kidney patients and controls, respectively, in Girandurukotte, and they were 18% and 7% in Kandy. The odds of exposure to hantaviruses were higher for kidney disease patients than for controls in both Girandurukotte (OR:3.66, 95% CI:2.01 to 6.64) and Kandy (OR:2.64, 95% CI:1.07 to 6.54) in binary logistic regression models. According to statistical analysis, individuals exposed to hantaviruses had a higher risk of developing renal impairment. Therefore, hantavirus infection might be an important risk factor for development of kidney disease in Sri Lanka. MDPI 2019-07-31 /pmc/articles/PMC6723923/ /pubmed/31370348 http://dx.doi.org/10.3390/v11080700 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sarathkumara, Yomani D.
Gamage, Chandika D.
Lokupathirage, Sithumini
Muthusinghe, Devinda S.
Nanayakkara, Nishantha
Gunarathne, Lishanthe
Shimizu, Kenta
Tsuda, Yoshimi
Arikawa, Jiro
Yoshimatsu, Kumiko
Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study
title Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study
title_full Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study
title_fullStr Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study
title_full_unstemmed Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study
title_short Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study
title_sort exposure to hantavirus is a risk factor associated with kidney diseases in sri lanka: a cross sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723923/
https://www.ncbi.nlm.nih.gov/pubmed/31370348
http://dx.doi.org/10.3390/v11080700
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