Cargando…
Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study
Chronic kidney disease of unknown etiology (CKDu) imposes a substantial burden on public health in Sri Lankan agricultural communities. High seroprevalences of hantavirus have been reported in CKDu patients in several locations of Sri Lanka. We carried out a cross-sectional study followed by an unma...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723923/ https://www.ncbi.nlm.nih.gov/pubmed/31370348 http://dx.doi.org/10.3390/v11080700 |
_version_ | 1783448883594002432 |
---|---|
author | Sarathkumara, Yomani D. Gamage, Chandika D. Lokupathirage, Sithumini Muthusinghe, Devinda S. Nanayakkara, Nishantha Gunarathne, Lishanthe Shimizu, Kenta Tsuda, Yoshimi Arikawa, Jiro Yoshimatsu, Kumiko |
author_facet | Sarathkumara, Yomani D. Gamage, Chandika D. Lokupathirage, Sithumini Muthusinghe, Devinda S. Nanayakkara, Nishantha Gunarathne, Lishanthe Shimizu, Kenta Tsuda, Yoshimi Arikawa, Jiro Yoshimatsu, Kumiko |
author_sort | Sarathkumara, Yomani D. |
collection | PubMed |
description | Chronic kidney disease of unknown etiology (CKDu) imposes a substantial burden on public health in Sri Lankan agricultural communities. High seroprevalences of hantavirus have been reported in CKDu patients in several locations of Sri Lanka. We carried out a cross-sectional study followed by an unmatched case-control comparison in two geographically distinct areas of Sri Lanka, Girandurukotte (CKDu endemic) and Kandy (CKDu non-endemic) to determine whether exposure to hantaviruses is a potential risk factor in patients with kidney disease. An indirect immunofluorescent antibody assay using two antigens, Thailand orthohantavirus-infected and recombinant N protein-expressing Vero E6 cells, were used for serodiagnosis. Participants’ demographic and other socio-economic data were collected through a structured questionnaire. Fifty kidney disease patients and 270 controls from Kandy and 104 kidney disease patients and 242 controls from Girandurukotte were examined. Seropositivities were 50% and 17.4% in kidney patients and controls, respectively, in Girandurukotte, and they were 18% and 7% in Kandy. The odds of exposure to hantaviruses were higher for kidney disease patients than for controls in both Girandurukotte (OR:3.66, 95% CI:2.01 to 6.64) and Kandy (OR:2.64, 95% CI:1.07 to 6.54) in binary logistic regression models. According to statistical analysis, individuals exposed to hantaviruses had a higher risk of developing renal impairment. Therefore, hantavirus infection might be an important risk factor for development of kidney disease in Sri Lanka. |
format | Online Article Text |
id | pubmed-6723923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67239232019-09-10 Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study Sarathkumara, Yomani D. Gamage, Chandika D. Lokupathirage, Sithumini Muthusinghe, Devinda S. Nanayakkara, Nishantha Gunarathne, Lishanthe Shimizu, Kenta Tsuda, Yoshimi Arikawa, Jiro Yoshimatsu, Kumiko Viruses Article Chronic kidney disease of unknown etiology (CKDu) imposes a substantial burden on public health in Sri Lankan agricultural communities. High seroprevalences of hantavirus have been reported in CKDu patients in several locations of Sri Lanka. We carried out a cross-sectional study followed by an unmatched case-control comparison in two geographically distinct areas of Sri Lanka, Girandurukotte (CKDu endemic) and Kandy (CKDu non-endemic) to determine whether exposure to hantaviruses is a potential risk factor in patients with kidney disease. An indirect immunofluorescent antibody assay using two antigens, Thailand orthohantavirus-infected and recombinant N protein-expressing Vero E6 cells, were used for serodiagnosis. Participants’ demographic and other socio-economic data were collected through a structured questionnaire. Fifty kidney disease patients and 270 controls from Kandy and 104 kidney disease patients and 242 controls from Girandurukotte were examined. Seropositivities were 50% and 17.4% in kidney patients and controls, respectively, in Girandurukotte, and they were 18% and 7% in Kandy. The odds of exposure to hantaviruses were higher for kidney disease patients than for controls in both Girandurukotte (OR:3.66, 95% CI:2.01 to 6.64) and Kandy (OR:2.64, 95% CI:1.07 to 6.54) in binary logistic regression models. According to statistical analysis, individuals exposed to hantaviruses had a higher risk of developing renal impairment. Therefore, hantavirus infection might be an important risk factor for development of kidney disease in Sri Lanka. MDPI 2019-07-31 /pmc/articles/PMC6723923/ /pubmed/31370348 http://dx.doi.org/10.3390/v11080700 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sarathkumara, Yomani D. Gamage, Chandika D. Lokupathirage, Sithumini Muthusinghe, Devinda S. Nanayakkara, Nishantha Gunarathne, Lishanthe Shimizu, Kenta Tsuda, Yoshimi Arikawa, Jiro Yoshimatsu, Kumiko Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study |
title | Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study |
title_full | Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study |
title_fullStr | Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study |
title_full_unstemmed | Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study |
title_short | Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study |
title_sort | exposure to hantavirus is a risk factor associated with kidney diseases in sri lanka: a cross sectional study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723923/ https://www.ncbi.nlm.nih.gov/pubmed/31370348 http://dx.doi.org/10.3390/v11080700 |
work_keys_str_mv | AT sarathkumarayomanid exposuretohantavirusisariskfactorassociatedwithkidneydiseasesinsrilankaacrosssectionalstudy AT gamagechandikad exposuretohantavirusisariskfactorassociatedwithkidneydiseasesinsrilankaacrosssectionalstudy AT lokupathiragesithumini exposuretohantavirusisariskfactorassociatedwithkidneydiseasesinsrilankaacrosssectionalstudy AT muthusinghedevindas exposuretohantavirusisariskfactorassociatedwithkidneydiseasesinsrilankaacrosssectionalstudy AT nanayakkaranishantha exposuretohantavirusisariskfactorassociatedwithkidneydiseasesinsrilankaacrosssectionalstudy AT gunarathnelishanthe exposuretohantavirusisariskfactorassociatedwithkidneydiseasesinsrilankaacrosssectionalstudy AT shimizukenta exposuretohantavirusisariskfactorassociatedwithkidneydiseasesinsrilankaacrosssectionalstudy AT tsudayoshimi exposuretohantavirusisariskfactorassociatedwithkidneydiseasesinsrilankaacrosssectionalstudy AT arikawajiro exposuretohantavirusisariskfactorassociatedwithkidneydiseasesinsrilankaacrosssectionalstudy AT yoshimatsukumiko exposuretohantavirusisariskfactorassociatedwithkidneydiseasesinsrilankaacrosssectionalstudy |