The Capability of O-Acetyl-ADP-Ribose, an Epigenetic Metabolic Small Molecule, on Promoting the Further Spreading of Sir3 along the Telomeric Chromatin

O-acetyl-ADP-ribose (AAR) is a metabolic small molecule relevant in epigenetics that is generated by NAD-dependent histone deacetylases, such as Sir2. The formation of silent heterochromatin in yeast requires histone deacetylation by Sir2, structural rearrangement of SIR complexes, spreading of SIR...

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Detalles Bibliográficos
Autores principales: Tung, Shu-Yun, Wang, Sue-Hong, Lee, Sue-Ping, Tsai, Shu-Ping, Su, Kuan-Chung, Shen, Hsiao-Hsuian, Hong, Jia-Yang, Tsai, Ming-Shiun, Liou, Gunn-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723988/
https://www.ncbi.nlm.nih.gov/pubmed/31366171
http://dx.doi.org/10.3390/genes10080577

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