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Micro-Pillar Integrated Dissolving Microneedles for Enhanced Transdermal Drug Delivery

The dissolving microneedle (DMN) patch is a transdermal delivery system, containing arrays of micro-sized polymeric needles capable of encapsulating therapeutic drugs within their matrix and releasing them into the skin. However, the elastic properties of the skin prevent DMNs from complete insertio...

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Autores principales: Lee, Seunghee, Fakhraei Lahiji, Shayan, Jang, Jeesu, Jang, Mingyu, Jung, Hyungil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724014/
https://www.ncbi.nlm.nih.gov/pubmed/31405191
http://dx.doi.org/10.3390/pharmaceutics11080402
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author Lee, Seunghee
Fakhraei Lahiji, Shayan
Jang, Jeesu
Jang, Mingyu
Jung, Hyungil
author_facet Lee, Seunghee
Fakhraei Lahiji, Shayan
Jang, Jeesu
Jang, Mingyu
Jung, Hyungil
author_sort Lee, Seunghee
collection PubMed
description The dissolving microneedle (DMN) patch is a transdermal delivery system, containing arrays of micro-sized polymeric needles capable of encapsulating therapeutic drugs within their matrix and releasing them into the skin. However, the elastic properties of the skin prevent DMNs from complete insertion and accurate delivery of encapsulated compounds into the skin. Moreover, the adhesive materials used in patches may cause skin irritation, inflammation, and redness. Therefore, we developed a patchless, micro-pillar integrated DMN (P-DMN) that is simple to fabricate and enhances transdermal drug delivery compared with traditional DMN patches. The micro-pillars were made of polymethyl methacrylate at a height of 300 μm and a base diameter of 500 μm. To fabricate P-DMNs, we employed hyaluronic acid, which is a widely used derma filler and plays a role in tissue re-epithelialization. We demonstrate that utilizing P-DMNs significantly improves the delivery efficiency of an encapsulated drug surrogate (91.83% ± 7.75%) compared with traditional DMNs (64.86% ± 8.17%). Interestingly, P-DMNs remarkably increase the skin penetration accuracy rate of encapsulated drugs, up to 97.78% ± 2.22%, compared with 44.44% ± 7.85% in traditional DMNs. Our findings suggest that P-DMNs could serve as a highly accurate and efficient platform for transdermal delivery of various types of micro- and macro-biomolecules.
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spelling pubmed-67240142019-09-10 Micro-Pillar Integrated Dissolving Microneedles for Enhanced Transdermal Drug Delivery Lee, Seunghee Fakhraei Lahiji, Shayan Jang, Jeesu Jang, Mingyu Jung, Hyungil Pharmaceutics Article The dissolving microneedle (DMN) patch is a transdermal delivery system, containing arrays of micro-sized polymeric needles capable of encapsulating therapeutic drugs within their matrix and releasing them into the skin. However, the elastic properties of the skin prevent DMNs from complete insertion and accurate delivery of encapsulated compounds into the skin. Moreover, the adhesive materials used in patches may cause skin irritation, inflammation, and redness. Therefore, we developed a patchless, micro-pillar integrated DMN (P-DMN) that is simple to fabricate and enhances transdermal drug delivery compared with traditional DMN patches. The micro-pillars were made of polymethyl methacrylate at a height of 300 μm and a base diameter of 500 μm. To fabricate P-DMNs, we employed hyaluronic acid, which is a widely used derma filler and plays a role in tissue re-epithelialization. We demonstrate that utilizing P-DMNs significantly improves the delivery efficiency of an encapsulated drug surrogate (91.83% ± 7.75%) compared with traditional DMNs (64.86% ± 8.17%). Interestingly, P-DMNs remarkably increase the skin penetration accuracy rate of encapsulated drugs, up to 97.78% ± 2.22%, compared with 44.44% ± 7.85% in traditional DMNs. Our findings suggest that P-DMNs could serve as a highly accurate and efficient platform for transdermal delivery of various types of micro- and macro-biomolecules. MDPI 2019-08-10 /pmc/articles/PMC6724014/ /pubmed/31405191 http://dx.doi.org/10.3390/pharmaceutics11080402 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Seunghee
Fakhraei Lahiji, Shayan
Jang, Jeesu
Jang, Mingyu
Jung, Hyungil
Micro-Pillar Integrated Dissolving Microneedles for Enhanced Transdermal Drug Delivery
title Micro-Pillar Integrated Dissolving Microneedles for Enhanced Transdermal Drug Delivery
title_full Micro-Pillar Integrated Dissolving Microneedles for Enhanced Transdermal Drug Delivery
title_fullStr Micro-Pillar Integrated Dissolving Microneedles for Enhanced Transdermal Drug Delivery
title_full_unstemmed Micro-Pillar Integrated Dissolving Microneedles for Enhanced Transdermal Drug Delivery
title_short Micro-Pillar Integrated Dissolving Microneedles for Enhanced Transdermal Drug Delivery
title_sort micro-pillar integrated dissolving microneedles for enhanced transdermal drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724014/
https://www.ncbi.nlm.nih.gov/pubmed/31405191
http://dx.doi.org/10.3390/pharmaceutics11080402
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