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Preparation of a Series of Photoresponsive Polymersomes Bearing Photocleavable a 2-nitrobenzyl Group at the Hydrophobic/Hydrophilic Interfaces and Their Payload Releasing Behaviors

In this study, the structure-function relationships of a series of polymersomes composed of well-defined amphiphilic diblock copolymers were investigated. The building blocks were synthesized by clicking hydrophobic polymers, synthesized beforehand, and commercially available poly(ethylene glycol) w...

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Autores principales: Yamamoto, Shota, Yamada, Takafumi, Kubo, Genki, Sakurai, Kazuo, Yamaguchi, Kazuo, Nakanishi, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724059/
https://www.ncbi.nlm.nih.gov/pubmed/31362443
http://dx.doi.org/10.3390/polym11081254
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author Yamamoto, Shota
Yamada, Takafumi
Kubo, Genki
Sakurai, Kazuo
Yamaguchi, Kazuo
Nakanishi, Jun
author_facet Yamamoto, Shota
Yamada, Takafumi
Kubo, Genki
Sakurai, Kazuo
Yamaguchi, Kazuo
Nakanishi, Jun
author_sort Yamamoto, Shota
collection PubMed
description In this study, the structure-function relationships of a series of polymersomes composed of well-defined amphiphilic diblock copolymers were investigated. The building blocks were synthesized by clicking hydrophobic polymers, synthesized beforehand, and commercially available poly(ethylene glycol) with photocleavable 2-nitrobenzyl compounds bearing alkyne and maleimide functionalities. All of the tested polymersomes preserved their hollow structures even after sufficient photoirradiation. Nevertheless, the release rate of an entrapped anionic fluorophore was highly dependent on the molecular weight and the type of hydrophobic polymer, as well as on the presence or absence of the charged end groups. Moreover, the polymersomes with a 2-nitrosobenzyl photolysis residue within the hydrophobic shells exhibited photo-induced payload release after complete photolysis. It was concluded that the payload release was mediated by photo-induced permeability changes of the hydrophobic shells rather than the decomposition of their overall structures.
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spelling pubmed-67240592019-09-10 Preparation of a Series of Photoresponsive Polymersomes Bearing Photocleavable a 2-nitrobenzyl Group at the Hydrophobic/Hydrophilic Interfaces and Their Payload Releasing Behaviors Yamamoto, Shota Yamada, Takafumi Kubo, Genki Sakurai, Kazuo Yamaguchi, Kazuo Nakanishi, Jun Polymers (Basel) Article In this study, the structure-function relationships of a series of polymersomes composed of well-defined amphiphilic diblock copolymers were investigated. The building blocks were synthesized by clicking hydrophobic polymers, synthesized beforehand, and commercially available poly(ethylene glycol) with photocleavable 2-nitrobenzyl compounds bearing alkyne and maleimide functionalities. All of the tested polymersomes preserved their hollow structures even after sufficient photoirradiation. Nevertheless, the release rate of an entrapped anionic fluorophore was highly dependent on the molecular weight and the type of hydrophobic polymer, as well as on the presence or absence of the charged end groups. Moreover, the polymersomes with a 2-nitrosobenzyl photolysis residue within the hydrophobic shells exhibited photo-induced payload release after complete photolysis. It was concluded that the payload release was mediated by photo-induced permeability changes of the hydrophobic shells rather than the decomposition of their overall structures. MDPI 2019-07-29 /pmc/articles/PMC6724059/ /pubmed/31362443 http://dx.doi.org/10.3390/polym11081254 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yamamoto, Shota
Yamada, Takafumi
Kubo, Genki
Sakurai, Kazuo
Yamaguchi, Kazuo
Nakanishi, Jun
Preparation of a Series of Photoresponsive Polymersomes Bearing Photocleavable a 2-nitrobenzyl Group at the Hydrophobic/Hydrophilic Interfaces and Their Payload Releasing Behaviors
title Preparation of a Series of Photoresponsive Polymersomes Bearing Photocleavable a 2-nitrobenzyl Group at the Hydrophobic/Hydrophilic Interfaces and Their Payload Releasing Behaviors
title_full Preparation of a Series of Photoresponsive Polymersomes Bearing Photocleavable a 2-nitrobenzyl Group at the Hydrophobic/Hydrophilic Interfaces and Their Payload Releasing Behaviors
title_fullStr Preparation of a Series of Photoresponsive Polymersomes Bearing Photocleavable a 2-nitrobenzyl Group at the Hydrophobic/Hydrophilic Interfaces and Their Payload Releasing Behaviors
title_full_unstemmed Preparation of a Series of Photoresponsive Polymersomes Bearing Photocleavable a 2-nitrobenzyl Group at the Hydrophobic/Hydrophilic Interfaces and Their Payload Releasing Behaviors
title_short Preparation of a Series of Photoresponsive Polymersomes Bearing Photocleavable a 2-nitrobenzyl Group at the Hydrophobic/Hydrophilic Interfaces and Their Payload Releasing Behaviors
title_sort preparation of a series of photoresponsive polymersomes bearing photocleavable a 2-nitrobenzyl group at the hydrophobic/hydrophilic interfaces and their payload releasing behaviors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724059/
https://www.ncbi.nlm.nih.gov/pubmed/31362443
http://dx.doi.org/10.3390/polym11081254
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