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Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease

Elastin degradation is accelerated in chronic obstructive pulmonary disease (COPD) and is partially regulated by Matrix Gla Protein (MGP), via a vitamin K-dependent pathway. The aim was to assess vitamin K status in COPD as well as associations between vitamin K status, elastin degradation, lung fun...

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Autores principales: Piscaer, Ianthe, van den Ouweland, Jody M. W., Vermeersch, Kristina, Reynaert, Niki L., Franssen, Frits M. E., Keene, Spencer, Wouters, Emiel F. M., Janssens, Wim, Vermeer, Cees, Janssen, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724066/
https://www.ncbi.nlm.nih.gov/pubmed/31357639
http://dx.doi.org/10.3390/jcm8081116
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author Piscaer, Ianthe
van den Ouweland, Jody M. W.
Vermeersch, Kristina
Reynaert, Niki L.
Franssen, Frits M. E.
Keene, Spencer
Wouters, Emiel F. M.
Janssens, Wim
Vermeer, Cees
Janssen, Rob
author_facet Piscaer, Ianthe
van den Ouweland, Jody M. W.
Vermeersch, Kristina
Reynaert, Niki L.
Franssen, Frits M. E.
Keene, Spencer
Wouters, Emiel F. M.
Janssens, Wim
Vermeer, Cees
Janssen, Rob
author_sort Piscaer, Ianthe
collection PubMed
description Elastin degradation is accelerated in chronic obstructive pulmonary disease (COPD) and is partially regulated by Matrix Gla Protein (MGP), via a vitamin K-dependent pathway. The aim was to assess vitamin K status in COPD as well as associations between vitamin K status, elastin degradation, lung function parameters and mortality. A total of 192 COPD patients and 186 age-matched controls were included. In addition to this, 290 COPD patients from a second independent longitudinal cohort were also included. Vitamin K status was assessed by measuring plasma inactive MGP levels and rates of elastin degradation by measuring plasma desmosine levels. Reduced vitamin K status was found in COPD patients compared to smoking controls (p < 0.0005) and controls who had never smoked (p = 0.001). Vitamin K status was inversely associated with desmosine (cohort 1: p = 0.001; cohort 2: p = 0.004). Only few significant associations between vitamin K status and lung function parameters were found. Mortality was higher in COPD patients within the quartile with the lowest vitamin K status compared to those within the other quartiles (hazard ratio 1.85, 95% confidence interval (CI), 1.21–2.83, p = 0.005). In conclusion, we demonstrated reduced vitamin K status in COPD and an inverse association between vitamin K status and elastin degradation rate. Our results therefore suggest a potential role of vitamin K in COPD pathogenesis.
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spelling pubmed-67240662019-09-10 Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease Piscaer, Ianthe van den Ouweland, Jody M. W. Vermeersch, Kristina Reynaert, Niki L. Franssen, Frits M. E. Keene, Spencer Wouters, Emiel F. M. Janssens, Wim Vermeer, Cees Janssen, Rob J Clin Med Article Elastin degradation is accelerated in chronic obstructive pulmonary disease (COPD) and is partially regulated by Matrix Gla Protein (MGP), via a vitamin K-dependent pathway. The aim was to assess vitamin K status in COPD as well as associations between vitamin K status, elastin degradation, lung function parameters and mortality. A total of 192 COPD patients and 186 age-matched controls were included. In addition to this, 290 COPD patients from a second independent longitudinal cohort were also included. Vitamin K status was assessed by measuring plasma inactive MGP levels and rates of elastin degradation by measuring plasma desmosine levels. Reduced vitamin K status was found in COPD patients compared to smoking controls (p < 0.0005) and controls who had never smoked (p = 0.001). Vitamin K status was inversely associated with desmosine (cohort 1: p = 0.001; cohort 2: p = 0.004). Only few significant associations between vitamin K status and lung function parameters were found. Mortality was higher in COPD patients within the quartile with the lowest vitamin K status compared to those within the other quartiles (hazard ratio 1.85, 95% confidence interval (CI), 1.21–2.83, p = 0.005). In conclusion, we demonstrated reduced vitamin K status in COPD and an inverse association between vitamin K status and elastin degradation rate. Our results therefore suggest a potential role of vitamin K in COPD pathogenesis. MDPI 2019-07-27 /pmc/articles/PMC6724066/ /pubmed/31357639 http://dx.doi.org/10.3390/jcm8081116 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Piscaer, Ianthe
van den Ouweland, Jody M. W.
Vermeersch, Kristina
Reynaert, Niki L.
Franssen, Frits M. E.
Keene, Spencer
Wouters, Emiel F. M.
Janssens, Wim
Vermeer, Cees
Janssen, Rob
Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease
title Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease
title_full Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease
title_fullStr Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease
title_full_unstemmed Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease
title_short Low Vitamin K Status Is Associated with Increased Elastin Degradation in Chronic Obstructive Pulmonary Disease
title_sort low vitamin k status is associated with increased elastin degradation in chronic obstructive pulmonary disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724066/
https://www.ncbi.nlm.nih.gov/pubmed/31357639
http://dx.doi.org/10.3390/jcm8081116
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