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The Effect of Dietary Supplementation of Crocetin for Myopia Control in Children: A Randomized Clinical Trial

The prevalence of myopia has been increasing in recent years. The natural carotenoid crocetin has been reported to suppress experimental myopia in mice. We evaluated the effects of crocetin on myopia suppression in children. A multicenter randomized double-blind placebo-controlled clinical trial was...

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Autores principales: Mori, Kiwako, Torii, Hidemasa, Fujimoto, Satoko, Jiang, Xiaoyan, Ikeda, Shin-ichi, Yotsukura, Erisa, Koh, Shizuka, Kurihara, Toshihide, Nishida, Kohji, Tsubota, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724222/
https://www.ncbi.nlm.nih.gov/pubmed/31394821
http://dx.doi.org/10.3390/jcm8081179
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author Mori, Kiwako
Torii, Hidemasa
Fujimoto, Satoko
Jiang, Xiaoyan
Ikeda, Shin-ichi
Yotsukura, Erisa
Koh, Shizuka
Kurihara, Toshihide
Nishida, Kohji
Tsubota, Kazuo
author_facet Mori, Kiwako
Torii, Hidemasa
Fujimoto, Satoko
Jiang, Xiaoyan
Ikeda, Shin-ichi
Yotsukura, Erisa
Koh, Shizuka
Kurihara, Toshihide
Nishida, Kohji
Tsubota, Kazuo
author_sort Mori, Kiwako
collection PubMed
description The prevalence of myopia has been increasing in recent years. The natural carotenoid crocetin has been reported to suppress experimental myopia in mice. We evaluated the effects of crocetin on myopia suppression in children. A multicenter randomized double-blind placebo-controlled clinical trial was performed with 69 participants aged 6 to 12 years, whose cycloplegic spherical equivalent refractions (SER) were between −1.5 and −4.5 diopter (D). The participants were randomized to receive either a placebo or crocetin and followed up for 24 weeks. Axial length (AL) elongation and changes in SER were evaluated for 24 weeks. Both written informed assent from the participants and written informed consent from legal guardians were obtained in this study because the selection criteria of this trial included children aged between 6 and 12 years old. This trial was approved by the institutional review boards. A mixed-effects model was used for analysis, using both eyes. Two participants dropped out and 67 children completed this trial. The change in SER in the placebo group, −0.41 ± 0.05 D (mean ± standard deviation), was significantly more myopic compared to that in the crocetin group, −0.33 ± 0.05 D (p = 0.049). The AL elongation in the placebo group, 0.21 ± 0.02 mm, was significantly bigger than that in the crocetin group, 0.18 ± 0.02 mm (p = 0.046). In conclusion, dietary crocetin may have a suppressive effect on myopia progression in children, but large-scale studies are required in order to confirm this effect.
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spelling pubmed-67242222019-09-10 The Effect of Dietary Supplementation of Crocetin for Myopia Control in Children: A Randomized Clinical Trial Mori, Kiwako Torii, Hidemasa Fujimoto, Satoko Jiang, Xiaoyan Ikeda, Shin-ichi Yotsukura, Erisa Koh, Shizuka Kurihara, Toshihide Nishida, Kohji Tsubota, Kazuo J Clin Med Article The prevalence of myopia has been increasing in recent years. The natural carotenoid crocetin has been reported to suppress experimental myopia in mice. We evaluated the effects of crocetin on myopia suppression in children. A multicenter randomized double-blind placebo-controlled clinical trial was performed with 69 participants aged 6 to 12 years, whose cycloplegic spherical equivalent refractions (SER) were between −1.5 and −4.5 diopter (D). The participants were randomized to receive either a placebo or crocetin and followed up for 24 weeks. Axial length (AL) elongation and changes in SER were evaluated for 24 weeks. Both written informed assent from the participants and written informed consent from legal guardians were obtained in this study because the selection criteria of this trial included children aged between 6 and 12 years old. This trial was approved by the institutional review boards. A mixed-effects model was used for analysis, using both eyes. Two participants dropped out and 67 children completed this trial. The change in SER in the placebo group, −0.41 ± 0.05 D (mean ± standard deviation), was significantly more myopic compared to that in the crocetin group, −0.33 ± 0.05 D (p = 0.049). The AL elongation in the placebo group, 0.21 ± 0.02 mm, was significantly bigger than that in the crocetin group, 0.18 ± 0.02 mm (p = 0.046). In conclusion, dietary crocetin may have a suppressive effect on myopia progression in children, but large-scale studies are required in order to confirm this effect. MDPI 2019-08-07 /pmc/articles/PMC6724222/ /pubmed/31394821 http://dx.doi.org/10.3390/jcm8081179 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mori, Kiwako
Torii, Hidemasa
Fujimoto, Satoko
Jiang, Xiaoyan
Ikeda, Shin-ichi
Yotsukura, Erisa
Koh, Shizuka
Kurihara, Toshihide
Nishida, Kohji
Tsubota, Kazuo
The Effect of Dietary Supplementation of Crocetin for Myopia Control in Children: A Randomized Clinical Trial
title The Effect of Dietary Supplementation of Crocetin for Myopia Control in Children: A Randomized Clinical Trial
title_full The Effect of Dietary Supplementation of Crocetin for Myopia Control in Children: A Randomized Clinical Trial
title_fullStr The Effect of Dietary Supplementation of Crocetin for Myopia Control in Children: A Randomized Clinical Trial
title_full_unstemmed The Effect of Dietary Supplementation of Crocetin for Myopia Control in Children: A Randomized Clinical Trial
title_short The Effect of Dietary Supplementation of Crocetin for Myopia Control in Children: A Randomized Clinical Trial
title_sort effect of dietary supplementation of crocetin for myopia control in children: a randomized clinical trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724222/
https://www.ncbi.nlm.nih.gov/pubmed/31394821
http://dx.doi.org/10.3390/jcm8081179
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