Study of the Immune Response in the Elderly: Is It Necessary to Develop a Vaccine against Neisseria meningitidis for the Aged?

Literature reports the association between aging and decline in the immune system function. The elderly have a higher risk of developing infectious diseases and are often less responsive to vaccines that are effective in the young. The case fatality rate of invasive meningococcal disease is higher i...

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Autores principales: Trzewikoswki de Lima, Gabriela, De Gaspari, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724425/
https://www.ncbi.nlm.nih.gov/pubmed/31534800
http://dx.doi.org/10.1155/2019/9287121
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author Trzewikoswki de Lima, Gabriela
De Gaspari, Elizabeth
author_facet Trzewikoswki de Lima, Gabriela
De Gaspari, Elizabeth
author_sort Trzewikoswki de Lima, Gabriela
collection PubMed
description Literature reports the association between aging and decline in the immune system function. The elderly have a higher risk of developing infectious diseases and are often less responsive to vaccines that are effective in the young. The case fatality rate of invasive meningococcal disease is higher in the elderly; therefore, vaccination for this population should be evaluated. Although new vaccines have been developed against Neisseria meningitidis, there is still a need to evaluate a vaccine for those older than 60 years, as the currently licensed vaccines are not indicated for this population.
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spelling pubmed-67244252019-09-18 Study of the Immune Response in the Elderly: Is It Necessary to Develop a Vaccine against Neisseria meningitidis for the Aged? Trzewikoswki de Lima, Gabriela De Gaspari, Elizabeth J Aging Res Review Article Literature reports the association between aging and decline in the immune system function. The elderly have a higher risk of developing infectious diseases and are often less responsive to vaccines that are effective in the young. The case fatality rate of invasive meningococcal disease is higher in the elderly; therefore, vaccination for this population should be evaluated. Although new vaccines have been developed against Neisseria meningitidis, there is still a need to evaluate a vaccine for those older than 60 years, as the currently licensed vaccines are not indicated for this population. Hindawi 2019-08-22 /pmc/articles/PMC6724425/ /pubmed/31534800 http://dx.doi.org/10.1155/2019/9287121 Text en Copyright © 2019 Gabriela Trzewikoswki de Lima and Elizabeth De Gaspari. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Trzewikoswki de Lima, Gabriela
De Gaspari, Elizabeth
Study of the Immune Response in the Elderly: Is It Necessary to Develop a Vaccine against Neisseria meningitidis for the Aged?
title Study of the Immune Response in the Elderly: Is It Necessary to Develop a Vaccine against Neisseria meningitidis for the Aged?
title_full Study of the Immune Response in the Elderly: Is It Necessary to Develop a Vaccine against Neisseria meningitidis for the Aged?
title_fullStr Study of the Immune Response in the Elderly: Is It Necessary to Develop a Vaccine against Neisseria meningitidis for the Aged?
title_full_unstemmed Study of the Immune Response in the Elderly: Is It Necessary to Develop a Vaccine against Neisseria meningitidis for the Aged?
title_short Study of the Immune Response in the Elderly: Is It Necessary to Develop a Vaccine against Neisseria meningitidis for the Aged?
title_sort study of the immune response in the elderly: is it necessary to develop a vaccine against neisseria meningitidis for the aged?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724425/
https://www.ncbi.nlm.nih.gov/pubmed/31534800
http://dx.doi.org/10.1155/2019/9287121
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