A Comparison of Phenotypic and Functional Properties of Mesenchymal Stromal Cells and Multipotent Adult Progenitor Cells

Both Multipotent Adult Progenitor Cells and Mesenchymal Stromal Cells are bone-marrow derived, non-haematopoietic adherent cells, that are well-known for having immunomodulatory and pro-angiogenic properties, whilst being relatively non-immunogenic. However, they are phenotypically and functionally...

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Autores principales: Khan, Reenam S., Newsome, Philip N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724467/
https://www.ncbi.nlm.nih.gov/pubmed/31555259
http://dx.doi.org/10.3389/fimmu.2019.01952
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author Khan, Reenam S.
Newsome, Philip N.
author_facet Khan, Reenam S.
Newsome, Philip N.
author_sort Khan, Reenam S.
collection PubMed
description Both Multipotent Adult Progenitor Cells and Mesenchymal Stromal Cells are bone-marrow derived, non-haematopoietic adherent cells, that are well-known for having immunomodulatory and pro-angiogenic properties, whilst being relatively non-immunogenic. However, they are phenotypically and functionally distinct cell types, which has implications for their efficacy in different settings. In this review we compare the phenotypic and functional properties of these two cell types, to help in determining which would be the superior cell type for different applications.
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spelling pubmed-67244672019-09-25 A Comparison of Phenotypic and Functional Properties of Mesenchymal Stromal Cells and Multipotent Adult Progenitor Cells Khan, Reenam S. Newsome, Philip N. Front Immunol Immunology Both Multipotent Adult Progenitor Cells and Mesenchymal Stromal Cells are bone-marrow derived, non-haematopoietic adherent cells, that are well-known for having immunomodulatory and pro-angiogenic properties, whilst being relatively non-immunogenic. However, they are phenotypically and functionally distinct cell types, which has implications for their efficacy in different settings. In this review we compare the phenotypic and functional properties of these two cell types, to help in determining which would be the superior cell type for different applications. Frontiers Media S.A. 2019-08-28 /pmc/articles/PMC6724467/ /pubmed/31555259 http://dx.doi.org/10.3389/fimmu.2019.01952 Text en Copyright © 2019 Khan and Newsome. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Khan, Reenam S.
Newsome, Philip N.
A Comparison of Phenotypic and Functional Properties of Mesenchymal Stromal Cells and Multipotent Adult Progenitor Cells
title A Comparison of Phenotypic and Functional Properties of Mesenchymal Stromal Cells and Multipotent Adult Progenitor Cells
title_full A Comparison of Phenotypic and Functional Properties of Mesenchymal Stromal Cells and Multipotent Adult Progenitor Cells
title_fullStr A Comparison of Phenotypic and Functional Properties of Mesenchymal Stromal Cells and Multipotent Adult Progenitor Cells
title_full_unstemmed A Comparison of Phenotypic and Functional Properties of Mesenchymal Stromal Cells and Multipotent Adult Progenitor Cells
title_short A Comparison of Phenotypic and Functional Properties of Mesenchymal Stromal Cells and Multipotent Adult Progenitor Cells
title_sort comparison of phenotypic and functional properties of mesenchymal stromal cells and multipotent adult progenitor cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724467/
https://www.ncbi.nlm.nih.gov/pubmed/31555259
http://dx.doi.org/10.3389/fimmu.2019.01952
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