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Crispr Library Screening: Genome‐Wide CRISPR‐Cas9 Screening Identifies NF‐κB/E2F6 Responsible for EGFRvIII‐Associated Temozolomide Resistance in Glioblastoma (Adv. Sci. 17/2019)
In article number 1900782, Xudong Wu, Tao Jiang, and Chunsheng Kang, and co‐workers present a genome‐wide screening under a clustered regularly interspaced short palindromic repeats (CRISPR)‐Cas9 library. Notably, E2F6 was proven to drive the temozolomide (TMZ) resistance of 191 glioblastoma‐related...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724468/ http://dx.doi.org/10.1002/advs.201970103 |
| _version_ | 1783449000365522944 |
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| author | Huang, Kai Liu, Xing Li, Yansheng Wang, Qixue Zhou, Junhu Wang, Yunfei Dong, Feng Yang, Chao Sun, Zhiyan Fang, Chuan Liu, Chaoyong Tan, Yanli Wu, Xudong Jiang, Tao Kang, Chunsheng |
| author_facet | Huang, Kai Liu, Xing Li, Yansheng Wang, Qixue Zhou, Junhu Wang, Yunfei Dong, Feng Yang, Chao Sun, Zhiyan Fang, Chuan Liu, Chaoyong Tan, Yanli Wu, Xudong Jiang, Tao Kang, Chunsheng |
| author_sort | Huang, Kai |
| collection | PubMed |
| description | In article number 1900782, Xudong Wu, Tao Jiang, and Chunsheng Kang, and co‐workers present a genome‐wide screening under a clustered regularly interspaced short palindromic repeats (CRISPR)‐Cas9 library. Notably, E2F6 was proven to drive the temozolomide (TMZ) resistance of 191 glioblastoma‐related candidate genes. To silence the expression of E2F6 is a promising strategy to conquer TMZ resistance in glioblastoma. [Image: see text] |
| format | Online Article Text |
| id | pubmed-6724468 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-67244682019-09-10 Crispr Library Screening: Genome‐Wide CRISPR‐Cas9 Screening Identifies NF‐κB/E2F6 Responsible for EGFRvIII‐Associated Temozolomide Resistance in Glioblastoma (Adv. Sci. 17/2019) Huang, Kai Liu, Xing Li, Yansheng Wang, Qixue Zhou, Junhu Wang, Yunfei Dong, Feng Yang, Chao Sun, Zhiyan Fang, Chuan Liu, Chaoyong Tan, Yanli Wu, Xudong Jiang, Tao Kang, Chunsheng Adv Sci (Weinh) Frontispiece In article number 1900782, Xudong Wu, Tao Jiang, and Chunsheng Kang, and co‐workers present a genome‐wide screening under a clustered regularly interspaced short palindromic repeats (CRISPR)‐Cas9 library. Notably, E2F6 was proven to drive the temozolomide (TMZ) resistance of 191 glioblastoma‐related candidate genes. To silence the expression of E2F6 is a promising strategy to conquer TMZ resistance in glioblastoma. [Image: see text] John Wiley and Sons Inc. 2019-09-04 /pmc/articles/PMC6724468/ http://dx.doi.org/10.1002/advs.201970103 Text en © 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Frontispiece Huang, Kai Liu, Xing Li, Yansheng Wang, Qixue Zhou, Junhu Wang, Yunfei Dong, Feng Yang, Chao Sun, Zhiyan Fang, Chuan Liu, Chaoyong Tan, Yanli Wu, Xudong Jiang, Tao Kang, Chunsheng Crispr Library Screening: Genome‐Wide CRISPR‐Cas9 Screening Identifies NF‐κB/E2F6 Responsible for EGFRvIII‐Associated Temozolomide Resistance in Glioblastoma (Adv. Sci. 17/2019) |
| title | Crispr Library Screening: Genome‐Wide CRISPR‐Cas9 Screening Identifies NF‐κB/E2F6 Responsible for EGFRvIII‐Associated Temozolomide Resistance in Glioblastoma (Adv. Sci. 17/2019) |
| title_full | Crispr Library Screening: Genome‐Wide CRISPR‐Cas9 Screening Identifies NF‐κB/E2F6 Responsible for EGFRvIII‐Associated Temozolomide Resistance in Glioblastoma (Adv. Sci. 17/2019) |
| title_fullStr | Crispr Library Screening: Genome‐Wide CRISPR‐Cas9 Screening Identifies NF‐κB/E2F6 Responsible for EGFRvIII‐Associated Temozolomide Resistance in Glioblastoma (Adv. Sci. 17/2019) |
| title_full_unstemmed | Crispr Library Screening: Genome‐Wide CRISPR‐Cas9 Screening Identifies NF‐κB/E2F6 Responsible for EGFRvIII‐Associated Temozolomide Resistance in Glioblastoma (Adv. Sci. 17/2019) |
| title_short | Crispr Library Screening: Genome‐Wide CRISPR‐Cas9 Screening Identifies NF‐κB/E2F6 Responsible for EGFRvIII‐Associated Temozolomide Resistance in Glioblastoma (Adv. Sci. 17/2019) |
| title_sort | crispr library screening: genome‐wide crispr‐cas9 screening identifies nf‐κb/e2f6 responsible for egfrviii‐associated temozolomide resistance in glioblastoma (adv. sci. 17/2019) |
| topic | Frontispiece |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724468/ http://dx.doi.org/10.1002/advs.201970103 |
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