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Human organoids: a new dimension in cell biology

Organoids derived from stem cells or tissues in culture can develop into structures that resemble the in vivo anatomy and physiology of intact organs. Human organoid cultures provide the potential to study human development and model disease processes with the same scrutiny and depth of analysis cus...

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Autores principales: Lehmann, Ruth, Lee, Connie M., Shugart, Erika C., Benedetti, Marta, Charo, R. Alta, Gartner, Zev, Hogan, Brigid, Knoblich, Jürgen, Nelson, Celeste M., Wilson, Kevin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724519/
https://www.ncbi.nlm.nih.gov/pubmed/31034354
http://dx.doi.org/10.1091/mbc.E19-03-0135
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author Lehmann, Ruth
Lee, Connie M.
Shugart, Erika C.
Benedetti, Marta
Charo, R. Alta
Gartner, Zev
Hogan, Brigid
Knoblich, Jürgen
Nelson, Celeste M.
Wilson, Kevin M.
author_facet Lehmann, Ruth
Lee, Connie M.
Shugart, Erika C.
Benedetti, Marta
Charo, R. Alta
Gartner, Zev
Hogan, Brigid
Knoblich, Jürgen
Nelson, Celeste M.
Wilson, Kevin M.
author_sort Lehmann, Ruth
collection PubMed
description Organoids derived from stem cells or tissues in culture can develop into structures that resemble the in vivo anatomy and physiology of intact organs. Human organoid cultures provide the potential to study human development and model disease processes with the same scrutiny and depth of analysis customary for research with nonhuman model organisms. Resembling the complexity of the actual tissue or organ, patient-derived human organoid studies may accelerate medical research, creating new opportunities for tissue engineering and regenerative medicine, generating knowledge and tools for preclinical studies, including drug development and testing. Biologists are drawn to this system as a new “model organism” to study complex disease phenotypes and genetic variability among individuals using patient-derived tissues. The American Society for Cell Biology convened a task force to report on the potential, challenges, and limitations for human organoid research. The task force suggests ways to ease the entry for new researchers into the field and how to facilitate broader use of this new model organism within the research community. This includes guidelines for reproducibility, culturing, sharing of patient materials, patient consent, training, and communication with the public.
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spelling pubmed-67245192019-09-05 Human organoids: a new dimension in cell biology Lehmann, Ruth Lee, Connie M. Shugart, Erika C. Benedetti, Marta Charo, R. Alta Gartner, Zev Hogan, Brigid Knoblich, Jürgen Nelson, Celeste M. Wilson, Kevin M. Mol Biol Cell Perspective Organoids derived from stem cells or tissues in culture can develop into structures that resemble the in vivo anatomy and physiology of intact organs. Human organoid cultures provide the potential to study human development and model disease processes with the same scrutiny and depth of analysis customary for research with nonhuman model organisms. Resembling the complexity of the actual tissue or organ, patient-derived human organoid studies may accelerate medical research, creating new opportunities for tissue engineering and regenerative medicine, generating knowledge and tools for preclinical studies, including drug development and testing. Biologists are drawn to this system as a new “model organism” to study complex disease phenotypes and genetic variability among individuals using patient-derived tissues. The American Society for Cell Biology convened a task force to report on the potential, challenges, and limitations for human organoid research. The task force suggests ways to ease the entry for new researchers into the field and how to facilitate broader use of this new model organism within the research community. This includes guidelines for reproducibility, culturing, sharing of patient materials, patient consent, training, and communication with the public. The American Society for Cell Biology 2019-05-01 /pmc/articles/PMC6724519/ /pubmed/31034354 http://dx.doi.org/10.1091/mbc.E19-03-0135 Text en © 2019 Lehmann et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology. http://creativecommons.org/licenses/by-nc-sa/3.0 This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License.
spellingShingle Perspective
Lehmann, Ruth
Lee, Connie M.
Shugart, Erika C.
Benedetti, Marta
Charo, R. Alta
Gartner, Zev
Hogan, Brigid
Knoblich, Jürgen
Nelson, Celeste M.
Wilson, Kevin M.
Human organoids: a new dimension in cell biology
title Human organoids: a new dimension in cell biology
title_full Human organoids: a new dimension in cell biology
title_fullStr Human organoids: a new dimension in cell biology
title_full_unstemmed Human organoids: a new dimension in cell biology
title_short Human organoids: a new dimension in cell biology
title_sort human organoids: a new dimension in cell biology
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724519/
https://www.ncbi.nlm.nih.gov/pubmed/31034354
http://dx.doi.org/10.1091/mbc.E19-03-0135
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