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Human organoids: a new dimension in cell biology
Organoids derived from stem cells or tissues in culture can develop into structures that resemble the in vivo anatomy and physiology of intact organs. Human organoid cultures provide the potential to study human development and model disease processes with the same scrutiny and depth of analysis cus...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724519/ https://www.ncbi.nlm.nih.gov/pubmed/31034354 http://dx.doi.org/10.1091/mbc.E19-03-0135 |
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author | Lehmann, Ruth Lee, Connie M. Shugart, Erika C. Benedetti, Marta Charo, R. Alta Gartner, Zev Hogan, Brigid Knoblich, Jürgen Nelson, Celeste M. Wilson, Kevin M. |
author_facet | Lehmann, Ruth Lee, Connie M. Shugart, Erika C. Benedetti, Marta Charo, R. Alta Gartner, Zev Hogan, Brigid Knoblich, Jürgen Nelson, Celeste M. Wilson, Kevin M. |
author_sort | Lehmann, Ruth |
collection | PubMed |
description | Organoids derived from stem cells or tissues in culture can develop into structures that resemble the in vivo anatomy and physiology of intact organs. Human organoid cultures provide the potential to study human development and model disease processes with the same scrutiny and depth of analysis customary for research with nonhuman model organisms. Resembling the complexity of the actual tissue or organ, patient-derived human organoid studies may accelerate medical research, creating new opportunities for tissue engineering and regenerative medicine, generating knowledge and tools for preclinical studies, including drug development and testing. Biologists are drawn to this system as a new “model organism” to study complex disease phenotypes and genetic variability among individuals using patient-derived tissues. The American Society for Cell Biology convened a task force to report on the potential, challenges, and limitations for human organoid research. The task force suggests ways to ease the entry for new researchers into the field and how to facilitate broader use of this new model organism within the research community. This includes guidelines for reproducibility, culturing, sharing of patient materials, patient consent, training, and communication with the public. |
format | Online Article Text |
id | pubmed-6724519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The American Society for Cell Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-67245192019-09-05 Human organoids: a new dimension in cell biology Lehmann, Ruth Lee, Connie M. Shugart, Erika C. Benedetti, Marta Charo, R. Alta Gartner, Zev Hogan, Brigid Knoblich, Jürgen Nelson, Celeste M. Wilson, Kevin M. Mol Biol Cell Perspective Organoids derived from stem cells or tissues in culture can develop into structures that resemble the in vivo anatomy and physiology of intact organs. Human organoid cultures provide the potential to study human development and model disease processes with the same scrutiny and depth of analysis customary for research with nonhuman model organisms. Resembling the complexity of the actual tissue or organ, patient-derived human organoid studies may accelerate medical research, creating new opportunities for tissue engineering and regenerative medicine, generating knowledge and tools for preclinical studies, including drug development and testing. Biologists are drawn to this system as a new “model organism” to study complex disease phenotypes and genetic variability among individuals using patient-derived tissues. The American Society for Cell Biology convened a task force to report on the potential, challenges, and limitations for human organoid research. The task force suggests ways to ease the entry for new researchers into the field and how to facilitate broader use of this new model organism within the research community. This includes guidelines for reproducibility, culturing, sharing of patient materials, patient consent, training, and communication with the public. The American Society for Cell Biology 2019-05-01 /pmc/articles/PMC6724519/ /pubmed/31034354 http://dx.doi.org/10.1091/mbc.E19-03-0135 Text en © 2019 Lehmann et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology. http://creativecommons.org/licenses/by-nc-sa/3.0 This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License. |
spellingShingle | Perspective Lehmann, Ruth Lee, Connie M. Shugart, Erika C. Benedetti, Marta Charo, R. Alta Gartner, Zev Hogan, Brigid Knoblich, Jürgen Nelson, Celeste M. Wilson, Kevin M. Human organoids: a new dimension in cell biology |
title | Human organoids: a new dimension in cell biology |
title_full | Human organoids: a new dimension in cell biology |
title_fullStr | Human organoids: a new dimension in cell biology |
title_full_unstemmed | Human organoids: a new dimension in cell biology |
title_short | Human organoids: a new dimension in cell biology |
title_sort | human organoids: a new dimension in cell biology |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724519/ https://www.ncbi.nlm.nih.gov/pubmed/31034354 http://dx.doi.org/10.1091/mbc.E19-03-0135 |
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