Cargando…

Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane

The anti-apoptotic Bcl-2 family protein Bcl-xL plays a critical role in cell survival by protecting the integrity of the mitochondrial outer membrane (MOM). The mechanism through which Bcl-xL is recruited to the MOM has not been fully discerned. The retromer is a conserved endosomal scaffold complex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Farmer, Trey, O’Neill, Katelyn L., Naslavsky, Naava, Luo, Xu, Caplan, Steve
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2019
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724524/ https://www.ncbi.nlm.nih.gov/pubmed/30840537 http://dx.doi.org/10.1091/mbc.E19-01-0044

Ejemplares similares

EHDs meet the retromer: Complex regulation of retrograde transport
por: Zhang, Jing, et al.
Publicado: (2012)

Defining the protein and lipid constituents of tubular recycling endosomes
por: Farmer, Trey, et al.
Publicado: (2021)

Vesicular trafficking plays a role in centriole disengagement and duplication
por: Xie, Shuwei, et al.
Publicado: (2018)

Receptor-mediated internalization promotes increased endosome size and number in a RAB4- and RAB5-dependent manner
por: Naslavsky, Naava, et al.
Publicado: (2023)

Role of Phosphatidylinositol 4,5-Bisphosphate in Regulating EHD2 Plasma Membrane Localization
por: Simone, Laura C., et al.
Publicado: (2013)

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane
por: O'Neill, Katelyn L., et al.
Publicado: (2016)

Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity
por: Park, Han-A, et al.
Publicado: (2017)

cPLA2α and EHD1 interact and regulate the vesiculation of cholesterol-rich, GPI-anchored, protein-containing endosomes
por: Cai, Bishuang, et al.
Publicado: (2012)

Role of the EHD2 Unstructured Loop in Dimerization, Protein Binding and Subcellular Localization
por: Bahl, Kriti, et al.
Publicado: (2015)

Eps15 Homology Domain Protein 4 (EHD4) is required for Eps15 Homology Domain Protein 1 (EHD1)-mediated endosomal recruitment and fission
por: Jones, Tyler, et al.
Publicado: (2020)

Differential requirements for the Eps15 homology domain proteins EHD4 and EHD2 in the regulation of mammalian ciliogenesis
por: Jones, Tyler, et al.
Publicado: (2022)

Coronin2A links actin-based endosomal processes to the EHD1 fission machinery
por: Dhawan, Kanika, et al.
Publicado: (2022)

EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole
por: Xie, Shuwei, et al.
Publicado: (2023)

Bcl-xL in neuroprotection and plasticity
por: Jonas, Elizabeth A., et al.
Publicado: (2014)

Trafficking cascades mediated by Rab35 and its membrane hub effector, MICAL-L1
por: Giridharan, Sai Srinivas Panapakkam, et al.
Publicado: (2012)

Prognostic significance of Bcl-xL expression and efficacy of Bcl-xL targeting therapy in urothelial carcinoma
por: Yoshimine, S, et al.
Publicado: (2013)

GRAF1 forms a complex with MICAL-L1 and EHD1 to cooperate in tubular recycling endosome vesiculation
por: Cai, Bishuang, et al.
Publicado: (2014)

Bcl-xL Promotes the Survival of Motor Neurons Derived from Neural Stem Cells
por: Wu, Yunqin, et al.
Publicado: (2023)

Combined inhibition of aurora kinases and Bcl-xL induces apoptosis through select BH3-only proteins
por: Li, Jian, et al.
Publicado: (2023)

Dynamics of Bcl-xL in Water and Membrane: Molecular Simulations
por: Maity, Atanu, et al.
Publicado: (2013)

Nutritional Regulators of Bcl-xL in the Brain
por: Park, Han-A, et al.
Publicado: (2018)

Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane
por: Kaufmann, Thomas, et al.
Publicado: (2003)

Mimicking Cdk2 phosphorylation of Bcl-xL at Ser73 results in caspase activation and Bcl-xL cleavage
por: Seng, NS, et al.
Publicado: (2016)

DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas
por: He, Yonghan, et al.
Publicado: (2020)

Effects of Cardiolipin on the Conformational Dynamics of Membrane-Anchored Bcl-xL
por: Tyagi, Vivek, et al.
Publicado: (2021)

HuR controls mitochondrial morphology through the regulation of Bcl(xL) translation
por: Durie, Danielle, et al.
Publicado: (2013)

Bax mitochondrial relocation is linked to its phosphorylation and its interaction with Bcl-xL
por: Garenne, David, et al.
Publicado: (2016)

Bcl-xL as a Modulator of Senescence and Aging
por: Mas-Bargues, Cristina, et al.
Publicado: (2021)

Bcl-xL: A Focus on Melanoma Pathobiology
por: Lucianò, Anna Maria, et al.
Publicado: (2021)

Involvement of Bcl-xL in Neuronal Function and Development
por: Bas, Julie, et al.
Publicado: (2021)

The Role of Bcl-xL Protein in Viral Infections
por: Wyżewski, Zbigniew, et al.
Publicado: (2021)

Roles and Regulation of BCL-xL in Hematological Malignancies
por: Morales-Martínez, Mario, et al.
Publicado: (2022)

Advances in Bcl-xL Research 2.0
por: Kervadec, Joann, et al.
Publicado: (2023)

Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport
por: Rajan, Sreekanth, et al.
Publicado: (2015)

Bcl-xL Is Required by Primary Hippocampal Neurons for Mitochondrial Motility and Proper Neurite Development
por: Jansen, Joseph, et al.
Publicado: (2022)

Mitochondrial Bcl-xL promotes brain synaptogenesis by controlling non-lethal caspase activation
por: Nguyen, Trang Thi Minh, et al.
Publicado: (2023)

Human Vam6p promotes lysosome clustering and fusion in vivo
por: Caplan, Steve, et al.
Publicado: (2001)

Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis
por: Giridharan, Sai Srinivas Panapakkam, et al.
Publicado: (2013)

Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin
por: Baranski, Zuzanna, et al.
Publicado: (2015)

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL
por: Follis, Ariele Viacava, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_b1qkac9bqqfv8sasampejs3d08