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Forceful closure: cytoskeletal networks in embryonic wound repair

Embryonic tissues heal wounds rapidly and without scarring, in a process conserved across species and driven by collective cell movements. The mechanisms of coordinated cell movement during embryonic wound closure also drive tissue development and cancer metastasis; therefore, embryonic wound repair...

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Detalles Bibliográficos
Autores principales: Rothenberg, Katheryn E., Fernandez-Gonzalez, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724689/
https://www.ncbi.nlm.nih.gov/pubmed/31145669
http://dx.doi.org/10.1091/mbc.E18-04-0248
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author Rothenberg, Katheryn E.
Fernandez-Gonzalez, Rodrigo
author_facet Rothenberg, Katheryn E.
Fernandez-Gonzalez, Rodrigo
author_sort Rothenberg, Katheryn E.
collection PubMed
description Embryonic tissues heal wounds rapidly and without scarring, in a process conserved across species and driven by collective cell movements. The mechanisms of coordinated cell movement during embryonic wound closure also drive tissue development and cancer metastasis; therefore, embryonic wound repair has received considerable attention as a model of collective cell migration. During wound closure, a supracellular actomyosin cable at the wound edge coordinates cells, while actin-based protrusions contribute to cell crawling and seamless wound healing. Other cytoskeletal networks are reorganized during wound repair: microtubules extend into protrusions and along cell–cell boundaries as cells stretch into damaged regions, septins accumulate at the wound margin, and intermediate filaments become polarized in the cells adjacent to the wound. Thus, diverse cytoskeletal networks work in concert to maintain tissue structure, while also driving and organizing cell movements to promote rapid repair. Understanding the signals that coordinate the dynamics of different cytoskeletal networks, and how adhesions between cells or with the extracellular matrix integrate forces across cells, will be important to elucidate the mechanisms of efficient embryonic wound healing and may have far-reaching implications for developmental and cancer cell biology.
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spelling pubmed-67246892019-09-06 Forceful closure: cytoskeletal networks in embryonic wound repair Rothenberg, Katheryn E. Fernandez-Gonzalez, Rodrigo Mol Biol Cell Perspective Embryonic tissues heal wounds rapidly and without scarring, in a process conserved across species and driven by collective cell movements. The mechanisms of coordinated cell movement during embryonic wound closure also drive tissue development and cancer metastasis; therefore, embryonic wound repair has received considerable attention as a model of collective cell migration. During wound closure, a supracellular actomyosin cable at the wound edge coordinates cells, while actin-based protrusions contribute to cell crawling and seamless wound healing. Other cytoskeletal networks are reorganized during wound repair: microtubules extend into protrusions and along cell–cell boundaries as cells stretch into damaged regions, septins accumulate at the wound margin, and intermediate filaments become polarized in the cells adjacent to the wound. Thus, diverse cytoskeletal networks work in concert to maintain tissue structure, while also driving and organizing cell movements to promote rapid repair. Understanding the signals that coordinate the dynamics of different cytoskeletal networks, and how adhesions between cells or with the extracellular matrix integrate forces across cells, will be important to elucidate the mechanisms of efficient embryonic wound healing and may have far-reaching implications for developmental and cancer cell biology. The American Society for Cell Biology 2019-06-01 /pmc/articles/PMC6724689/ /pubmed/31145669 http://dx.doi.org/10.1091/mbc.E18-04-0248 Text en © 2019 Rothenberg and Fernandez-Gonzalez. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology. http://creativecommons.org/licenses/by-nc-sa/3.0 This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License.
spellingShingle Perspective
Rothenberg, Katheryn E.
Fernandez-Gonzalez, Rodrigo
Forceful closure: cytoskeletal networks in embryonic wound repair
title Forceful closure: cytoskeletal networks in embryonic wound repair
title_full Forceful closure: cytoskeletal networks in embryonic wound repair
title_fullStr Forceful closure: cytoskeletal networks in embryonic wound repair
title_full_unstemmed Forceful closure: cytoskeletal networks in embryonic wound repair
title_short Forceful closure: cytoskeletal networks in embryonic wound repair
title_sort forceful closure: cytoskeletal networks in embryonic wound repair
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724689/
https://www.ncbi.nlm.nih.gov/pubmed/31145669
http://dx.doi.org/10.1091/mbc.E18-04-0248
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