VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy

Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether...

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Detalles Bibliográficos
Autores principales: da Silva, Ronaldo Celerino, Alves, Neyla Maria Pereira, Pereira, Jorge José de Souza, Coelho, Antonio Victor Campos, Arraes, Luiz Cláudio, Brandão, Lucas André Cavalcanti, Crovella, Sergio, Silva, Jaqueline de Azevêdo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2019
Materias:
Human and Medical Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726152/
https://www.ncbi.nlm.nih.gov/pubmed/31259360
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0289
Descripción
Sumario:Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether a VDR SNP (rs11568820: C allele and CC genotype) and GC (rs2228570-rs11568820) allelic combinations are associated with immunological failure (p < 0.05). Our findings suggest a possible role of VDR SNPs on immunological failure in HIV-1+ individuals undergoing regular ARVs.

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