VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy

Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether...

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Autores principales: da Silva, Ronaldo Celerino, Alves, Neyla Maria Pereira, Pereira, Jorge José de Souza, Coelho, Antonio Victor Campos, Arraes, Luiz Cláudio, Brandão, Lucas André Cavalcanti, Crovella, Sergio, Silva, Jaqueline de Azevêdo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2019
Materias:
Human and Medical Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726152/
https://www.ncbi.nlm.nih.gov/pubmed/31259360
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0289
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author da Silva, Ronaldo Celerino
Alves, Neyla Maria Pereira
Pereira, Jorge José de Souza
Coelho, Antonio Victor Campos
Arraes, Luiz Cláudio
Brandão, Lucas André Cavalcanti
Crovella, Sergio
Silva, Jaqueline de Azevêdo
author_facet da Silva, Ronaldo Celerino
Alves, Neyla Maria Pereira
Pereira, Jorge José de Souza
Coelho, Antonio Victor Campos
Arraes, Luiz Cláudio
Brandão, Lucas André Cavalcanti
Crovella, Sergio
Silva, Jaqueline de Azevêdo
author_sort da Silva, Ronaldo Celerino
collection PubMed
description Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether a VDR SNP (rs11568820: C allele and CC genotype) and GC (rs2228570-rs11568820) allelic combinations are associated with immunological failure (p < 0.05). Our findings suggest a possible role of VDR SNPs on immunological failure in HIV-1+ individuals undergoing regular ARVs.
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spelling pubmed-67261522019-09-12 VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy da Silva, Ronaldo Celerino Alves, Neyla Maria Pereira Pereira, Jorge José de Souza Coelho, Antonio Victor Campos Arraes, Luiz Cláudio Brandão, Lucas André Cavalcanti Crovella, Sergio Silva, Jaqueline de Azevêdo Genet Mol Biol Human and Medical Genetics Vitamin D exerts an immuno-modulatory activity on several immune system cells through the vitamin D receptor (VDR). Herein, we verified that age and a therapeutic regimen containing protease inhibitors are associated with failures in antiretroviral therapies (ARVs). In addition, we assessed whether a VDR SNP (rs11568820: C allele and CC genotype) and GC (rs2228570-rs11568820) allelic combinations are associated with immunological failure (p < 0.05). Our findings suggest a possible role of VDR SNPs on immunological failure in HIV-1+ individuals undergoing regular ARVs. Sociedade Brasileira de Genética 2019-06-27 2019 /pmc/articles/PMC6726152/ /pubmed/31259360 http://dx.doi.org/10.1590/1678-4685-GMB-2017-0289 Text en Copyright © 2019, Sociedade Brasileira de Genética. https://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
spellingShingle Human and Medical Genetics
da Silva, Ronaldo Celerino
Alves, Neyla Maria Pereira
Pereira, Jorge José de Souza
Coelho, Antonio Victor Campos
Arraes, Luiz Cláudio
Brandão, Lucas André Cavalcanti
Crovella, Sergio
Silva, Jaqueline de Azevêdo
VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy
title VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy
title_full VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy
title_fullStr VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy
title_full_unstemmed VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy
title_short VDR polymorphisms influence immunological response in HIV-1+ individuals undergoing antiretroviral therapy
title_sort vdr polymorphisms influence immunological response in hiv-1+ individuals undergoing antiretroviral therapy
topic Human and Medical Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726152/
https://www.ncbi.nlm.nih.gov/pubmed/31259360
http://dx.doi.org/10.1590/1678-4685-GMB-2017-0289
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